{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:28:41Z","timestamp":1793456921496,"version":"4.5.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."],"award-info":[{"award-number":["The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."],"award-info":[{"award-number":["The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","award":["The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."],"award-info":[{"award-number":["The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Sporotrichosis is a subcutaneous mycosis with a global distribution, also known as \u201crose gardener\u2019s disease\u201d. Brazil is experiencing a rapid spread of the zoonotic transmission of of <jats:italic>Sporothrix brasiliensis<\/jats:italic>, the main etiological agent of this disease in this country, affecting domestic felines. Cost-effective interventions need to be developed to control this emergent public health problem. To allow for the comparison of alternative control strategies, we propose in this paper, a mathematical model representing the transmission of <jats:italic>S. brasiliensis<\/jats:italic> among cats, stratified by age and sex. Analytical properties of the model are derived and simulations show possible strategies for reducing the endemic levels of the disease in the cat population, with a positive impact on human health. The scenarios included mass treatment of infected cats and mass implementation of contact reduction practices, such as neutering. The results indicate that mass treatment can reduce substantially the disease prevalence, and this effect is potentialized when combined with neutering or other contact-reduction interventions. On the other hand, contact-reduction methods alone are not sufficient to reduce prevalence.<\/jats:p>","DOI":"10.1371\/journal.pone.0272672","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T18:27:50Z","timestamp":1675708070000},"page":"e0272672","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mathematical model of the dynamics of transmission and control of sporotrichosis in domestic cats"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-3393","authenticated-orcid":true,"given":"Aur\u00e9lio A.","family":"Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"Code\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-2438","authenticated-orcid":true,"given":"Dayvison","family":"F. 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Avalia\u00e7\u00e3o de fatores epidemiol\u00f3gicos, micol\u00f3gicos, cl\u00ednicos e terap\u00eauticos associados \u00e0 esporotricose. Tese (Doutorado em Medicina Tropical)\u2014Instituto Oswaldo Cruz. 2014;."},{"key":"pone.0272672.ref011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-319-11912-0_6","volume-title":"Sporotrichosis","author":"SA Pereira","year":"2015"},{"issue":"9","key":"pone.0272672.ref012","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-4362.2003.01813.x","article-title":"Sporotrichosis with widespread cutaneous lesions: report of 24 cases related to transmission by domestic cats in Rio de Janeiro, Brazil","volume":"42","author":"MB de Lima Barros","year":"2003","journal-title":"International journal of dermatology"},{"issue":"4","key":"pone.0272672.ref013","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1086\/381200","article-title":"Cat-transmitted sporotrichosis epidemic in Rio de Janeiro, Brazil: description of a series of cases","volume":"38","author":"MBdL Barros","year":"2004","journal-title":"Clinical Infectious Diseases"},{"issue":"1","key":"pone.0272672.ref014","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0190-9622(86)70139-4","article-title":"Feline sporotrichosis: a report of five cases with transmission to humans","volume":"15","author":"RW Dunstan","year":"1986","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"1","key":"pone.0272672.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-014-0269-5","article-title":"Feline sporotrichosis due to Sporothrix brasiliensis: an emerging animal infection in S\u00e3o Paulo, Brazil","volume":"10","author":"H Montenegro","year":"2014","journal-title":"BMC veterinary research"},{"issue":"8","key":"pone.0272672.ref016","doi-asserted-by":"crossref","first-page":"e0004016","DOI":"10.1371\/journal.pntd.0004016","article-title":"Proteomics-based characterization of the humoral immune response in sporotrichosis: toward discovery of potential diagnostic and vaccine antigens","volume":"9","author":"AM Rodrigues","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"1","key":"pone.0272672.ref017","doi-asserted-by":"crossref","first-page":"e1006077","DOI":"10.1371\/journal.ppat.1006077","article-title":"Zoonotic epidemic of sporotrichosis: cat to human transmission","volume":"13","author":"IDF Gremi\u00e3o","year":"2017","journal-title":"PLoS pathogens"},{"issue":"2","key":"pone.0272672.ref018","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/tropicalmed4020081","article-title":"Diagnosis and Management of Fungal Neglected Tropical Diseases In Community Settings\u2014Mycetoma and Sporotrichosis","volume":"4","author":"R Estrada-Casta\u00f1\u00f3n","year":"2019","journal-title":"Tropical medicine and infectious disease"},{"issue":"1","key":"pone.0272672.ref019","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1086\/345437","article-title":"Population-based surveillance and a case-control study of risk factors for endemic lymphocutaneous sporotrichosis in Peru","volume":"36","author":"G Lyon","year":"2003","journal-title":"Clinical infectious diseases"},{"issue":"2","key":"pone.0272672.ref020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1863-2378.2012.01506.x","article-title":"Treatment abandonment in feline sporotrichosis\u2013Study of 147 cases","volume":"60","author":"A Chaves","year":"2013","journal-title":"Zoonoses and public health"},{"issue":"10","key":"pone.0272672.ref021","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.2460\/javma.2004.224.1623","article-title":"Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998\u20132001)","volume":"224","author":"TM Schubach","year":"2004","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"pone.0272672.ref022","unstructured":"Nascimento JMV. Estudo de interven\u00e7\u00e3o em Educa\u00e7\u00e3o em Sa\u00fade: uma estrat\u00e9gia para a redu\u00e7\u00e3o do abandono de tratamento da esporotricose felina. Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro; 2019."},{"issue":"6","key":"pone.0272672.ref023","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1590\/S0102-09352012000600017","article-title":"Caracteriza\u00e7\u00e3o demogr\u00e1fica das popula\u00e7\u00f5es de c\u00e3es e gatos supervisionados do munic\u00edpio de S\u00e3o Paulo","volume":"64","author":"BD Canatto","year":"2012","journal-title":"Arquivo Brasileiro de Medicina Veterin\u00e1ria e Zootecnia"},{"issue":"1","key":"pone.0272672.ref024","first-page":"163","article-title":"Embryo tecnology in conservation efforts for endangered felids","volume":"53","author":"CE Papa","year":"2020","journal-title":"PUBMED"},{"issue":"1","key":"pone.0272672.ref025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1748-5827.1977.tb05821.x","article-title":"A survey of sexual behaviour and reproduction of female cats","volume":"18","author":"J Jemmett","year":"1977","journal-title":"Journal of Small Animal Practice"},{"key":"pone.0272672.ref026","unstructured":"DIAS CGA. Caracter\u00edsticas reprodutivas durante a c\u00f3pula, gesta\u00e7\u00e3o, p\u00f3sparto e estudo das rela\u00e7\u00f5es materno-filiais em gatos dom\u00e9sticos (Felis silvestris catus) mantidos em gatil experimental sob fotoper\u00edodo equatorial natural. Universidade Estadual do Cear\u00e1. 2006;."},{"issue":"1-2","key":"pone.0272672.ref027","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0025-5564(02)00108-6","article-title":"Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission","volume":"180","author":"P Van den Driessche","year":"2002","journal-title":"Mathematical biosciences"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0272672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T18:28:24Z","timestamp":1675708104000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0272672"}},"subtitle":[],"editor":[{"given":"Sebasti\u00e1n","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0272672","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]}}}