{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:23:33Z","timestamp":1773714213574,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danish Health Foundation Helsefonden","award":["18-B-0355"],"award-info":[{"award-number":["18-B-0355"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Denmark has experienced a remarkable reduction in CVD mortality over recent decades. The scale of the health contribution from the Danish regulation on industrially produced <jats:italic>trans<\/jats:italic> fatty acid (ITFA) has therefore long been of interest. Thus the objective was to determine health and equity benefits of the Danish regulation on ITFA content in Danish food, by quantifying the relative contributions of changes in ITFA intake, other risk factors and treatments on coronary heart disease (CHD) mortality decline from 1991 to 2007 in Denmark, stratified by socioeconomic group. To evaluate the effects of the ITFA ban (Danish Order no. 160 of March 2003) the Danish IMPACT<jats:sub>SEC<\/jats:sub> model was extended to quantify reductions in CHD deaths attributable to changes in ITFA (%E) intake between 1991\u20132007. Population counts were obtained from the Danish Central Office of Civil Registration, financial income from Statistics Denmark and ITFA intake from <jats:italic>Dan-MONICA III (1991)<\/jats:italic> and <jats:italic>DANSDA (2005\u20132008)<\/jats:italic>. Participants were adults aged 25\u201384 years living in Denmark in 1991 and 2007, stratified by socioeconomic quintiles. The main outcome measure was CHD deaths prevented or postponed (DPP). Mean energy intake from ITFA was decimated between 1991 and 2007, falling from 1.1%E to 0.1%E in men and from 1\u00b70%E to 0\u00b71%E in women. Approximately 1,191 (95% CI 989\u20131,409) fewer CHD deaths were attributable to the ITFA reduction, representing some 11% of the overall 11,100 mortality fall observed in the period. The greatest attributable mortality falls were seen in the most deprived quintiles. Adding ITFA data to the original IMPACTsec model improved the overall model fit from 64% to 73%. In conclusion: Denmark\u2019s mandatory elimination of ITFA accounted for approximately 11% of the substantial reduction in CHD deaths observed between 1991 and 2007. The most deprived groups benefited the most, thus reducing inequalities. Adopting the Danish ITFA regulatory approach elsewhere could substantially reduce CHD mortality while improving health equity.<\/jats:p>","DOI":"10.1371\/journal.pone.0272744","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T17:31:21Z","timestamp":1660757481000},"page":"e0272744","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Quantifying benefits of the Danish transfat ban for coronary heart disease mortality 1991\u20132007: Socioeconomic analysis using the IMPACTsec model"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-8310","authenticated-orcid":true,"given":"Kirsten Schroll","family":"Bjoernsbo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert Marni","family":"Joensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Joergensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soeren","family":"Lundbye-Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Bysted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7693-7359","authenticated-orcid":true,"given":"Tue","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisse","family":"Fagt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Capewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"O\u2019Flaherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"issue":"25","key":"pone.0272744.ref001","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update from the GBD 2019 Study","volume":"76","author":"GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"pone.0272744.ref002","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1056\/NEJMra054035","article-title":"Trans fatty acids and cardiovascular disease","volume":"354","author":"D Mozaffarian","year":"2006","journal-title":"N Engl J Med"},{"key":"pone.0272744.ref003","unstructured":"WHO: Thirteenth General programme of Work 2019\u20132023. 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