{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:26:02Z","timestamp":1791656762685,"version":"4.3.4"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"Fundamental Research Grant Scheme","award":["FP004-2017A"],"award-info":[{"award-number":["FP004-2017A"]}]},{"name":"University of Malaya Special Research Fund Assistance","award":["BKS005-2017"],"award-info":[{"award-number":["BKS005-2017"]}]},{"name":"Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases","award":["5R01AI13094s5"],"award-info":[{"award-number":["5R01AI13094s5"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In Malaysia, soil-transmitted helminth (STH) infections still persist among indigenous communities. In the past, local studies have focused mostly on epidemiologic aspects of STH infections with a scarcity of information on the efficacy of deworming treatment. The present study consisted of 2 phases: a cross-sectional phase on current epidemiological status and risk factors of STH infections and a longitudinal study over 6 weeks on triple dose albendazole efficacy against STH infections. A total of 253 participants were recruited at baseline and a pre-tested questionnaire was administered to obtain information on socio-demographics, environmental and behavioural risk factors. Stool samples were evaluated using a modified Kato-Katz technique. Cure rate (CR) and egg reduction rate (ERR) were assessed at 3 weeks following a 3-day course of 400mg albendazole treatment and infection status were observed again at 6 weeks. Baseline positivity of trichuriasis, ascariasis and hookworm infections were 56.1%, 11.9% and 20.2%, respectively. Multivariate analysis showed age below 18 years old (<jats:italic>P<\/jats:italic> = 0.004), without latrine in house (<jats:italic>P<\/jats:italic> = 0.042) and indiscriminate defecation (<jats:italic>P<\/jats:italic> = 0.032) were associated with STH infections. In the longitudinal study (N = 89), CR for trichuriasis was 64.6%, while CR of 100% was observed for both ascariasis and hookworm. ERR was above 90% for all three STH species. A rapid increased of <jats:italic>Trichuris trichiura<\/jats:italic> egg output was observed at 6 weeks. In conclusion, STH infections are highly prevalent among indigenous communities. Children and teenagers, poor sanitation and hygiene behaviour were determinants for STH infections. Triple dose albendazole is found to be efficacious against <jats:italic>Ascaris lumbricoides<\/jats:italic> and hookworm infections but has moderate curative effect with high ERR against <jats:italic>T<\/jats:italic>. <jats:italic>trichiura<\/jats:italic>. Although triple dose albendazole regimen has logistic challenges and may not be a routine option, consideration of this treatment regime may still be necessary in selective communities to reduce high intensity of <jats:italic>T<\/jats:italic>. <jats:italic>trichiura<\/jats:italic> infection.<\/jats:p>","DOI":"10.1371\/journal.pone.0272821","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T20:24:17Z","timestamp":1660335857000},"page":"e0272821","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of triple dose albendazole treatment for soil-transmitted helminth infections"],"prefix":"10.1371","volume":"17","author":[{"given":"Mian Zi","family":"Tee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-2265","authenticated-orcid":true,"given":"Soo Ching","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-4920","authenticated-orcid":true,"given":"Yi Xian","family":"Er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6971-2717","authenticated-orcid":true,"given":"Nan Jiun","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano","family":"Ngui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-9415","authenticated-orcid":true,"given":"Alice V.","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-8821","authenticated-orcid":true,"given":"Vinnie Wei Yin","family":"Siow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-0554","authenticated-orcid":true,"given":"Kee Seong","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Chiong Meng","family":"Boey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-9994","authenticated-orcid":true,"given":"Kek Heng","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-0661","authenticated-orcid":true,"given":"Ken","family":"Cadwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6211-3292","authenticated-orcid":true,"given":"P\u2019ng","family":"Loke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Ai Lian","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"pone.0272821.ref001","author":"World Health Organization","year":"2021","journal-title":"Fact Sheet. 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