{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:04:29Z","timestamp":1782965069591,"version":"3.54.5"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the impact of a history of recurrent ectopic pregnancy (EP) on pregnancy outcomes of subsequent in vitro fertilization (IVF) treatment.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study involving 457 women with a history of recurrent EP (REP group), 912 women with a history of single EP (SEP group), and 1169 women with a history of intrauterine pregnancy (IUP group) as the control group, was conducted. IVF outcomes were compared for each cohort.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The incidence of EP in the REP group after IVF treatment was significantly lower than those in the SEP group (2.4% vs. 6.8%, P = 0.011), and similar to those in the IUP group (2.4% vs. 2.1%, P = 0.830). No significant differences were observed in the clinical pregnancy rate, miscarriage rate, and live birth rate among the three groups. There was no statistically significant difference in the recurrent EP rate between the salpingectomy and salpingostomy treatments. Adjusting for maternal and treatment factors did not influence live birth rates for women with previous REP compared with women with previous SEP and those with IUP. The odds of EP were 82.2% lower (OR 0.178, 95% CI 0.042\u20130.762; P = 0.020) in women who had blastocyst transfer compared with cleavage embryo transfer in the SEP group. The odds of EP were over six times (OR 6.260, 95% CI 1.255\u201331.220; P = 0.025) in women who underwent double embryo transfer as opposed to single embryo transfer in the IUP group.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that women with previous recurrent EP have a lower risk of EP after IVF in comparison with women with previous single EP. Previous EP has no significant adverse effect on the main IVF outcomes. The salpingostomy and salpingectomy treatments of EP do not significantly affect the incidence of recurrent EP after IVF.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0272949","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T17:31:15Z","timestamp":1660584675000},"page":"e0272949","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pregnancy outcomes following in vitro fertilization treatment in women with previous recurrent ectopic pregnancy"],"prefix":"10.1371","volume":"17","author":[{"given":"Yamei","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8044-6237","authenticated-orcid":true,"given":"Songying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"pone.0272949.ref001","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/AOG.0b013e3181d0c328","article-title":"Trends in the diagnosis and treatment of ectopic pregnancy in the United States","volume":"115","author":"KW Hoover","year":"2010","journal-title":"Obstet Gynecol"},{"key":"pone.0272949.ref002","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.fertnstert.2018.08.022","article-title":"Demographic, lifestyle, and reproductive risk factors for ectopic pregnancy","volume":"110","author":"AJ Gaskins","year":"2018","journal-title":"Fertil Steril"},{"key":"pone.0272949.ref003","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fertnstert.2019.03.019","article-title":"Ectopic pregnancy and outcomes of future intrauterine pregnancy","volume":"112","author":"M Chouinard","year":"2019","journal-title":"Fertil Steril"},{"key":"pone.0272949.ref004","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.fertnstert.2015.04.009","article-title":"Ectopic pregnancy after in vitro fertilization: differences between fresh and frozen-thawed cycles","volume":"104","author":"L Londra","year":"2015","journal-title":"Fertil Steril"},{"key":"pone.0272949.ref005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.fertnstert.2016.02.035","article-title":"Risk factors for ectopic pregnancy in assisted reproductive technology: a 6-year, single-center study","volume":"106","author":"Z Bu","year":"2016","journal-title":"Fertil Steril"},{"key":"pone.0272949.ref006","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1097\/CM9.0000000000001058","article-title":"Factors associated with the incidence of ectopic pregnancy in women undergoing assisted reproductive treatment","volume":"133","author":"XY Jin","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"pone.0272949.ref007","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.fertnstert.2015.08.034","article-title":"Effect of treatment of a previous ectopic pregnancy on in vitro fertilization-intracytoplasmic sperm injection outcomes: a retrospective cohort study","volume":"104","author":"Z Xu","year":"2015","journal-title":"Fertil Steril"},{"key":"pone.0272949.ref008","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.fertnstert.2019.12.036","article-title":"Tubal factor infertility with prior ectopic pregnancy: a double whammy? 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