{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:24:06Z","timestamp":1785507846606,"version":"3.56.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>There are a few reports of TB disease among healthcare workers (HCWs) in Thailand. The authors assessed the demographic data and incidence of overall TB disease including specific profession among HCWs in order to reduce the incidence rate.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This was a descriptive, cross-sectional study of 195 HCWs at King Chulalongkorn Memorial Hospital (KCMH), Bangkok, Thailand, who had TB disease from 2003\u20132020.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The average incidence of TB disease in HCWs at KCMH was 164 per 100,000 HCWs with 95% confidential interval [CI], 107 to 220; (94.4% had pulmonary TB). Most of the HCWs were from a young age group (43.08% were 20\u201329 years old) and the duration of work was short (58.82% had worked at KCMH for less than 5 years). Radiological technicians had the highest incidence of TB, followed by supportive teams, scientists, and physicians (429, 241, 205, and 193 per 100,000 HCWs according to their profession, respectively). Seventy five percent of TB disease was found in physicians who worked at KCMH within 2 years. TB incidence was highest among residents (688 per 100,000 residents) in a subgroup of physicians.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The incidence of TB disease in HCWs was close to the general population of Thailand (153 per 100,000 population with 95% CI, 116 to 195). A higher incidence was observed in the profession that had contact with TB patients and their specimens. A high proportion of asymptomatic HCWs also had TB disease and TB incidence was found in a new generation of HCWs who have worked for less than 5 years. More rigorous epidemiology investigations are needed to establish a definitive relation to subsequently developing TB after working in a hospital. The authors suggest active surveillance in all new incoming HCWs and TB preventive therapy should also be provided to recent converters.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0273027","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T17:40:37Z","timestamp":1661362837000},"page":"e0273027","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tuberculosis at a university hospital, Thailand: A surprising incidence of TB among a new generation of highly exposed health care workers who may be asymptomatic"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-0131","authenticated-orcid":true,"given":"Pichanon","family":"Mingchay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilani","family":"Paitoonpong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-7328","authenticated-orcid":true,"given":"Kamon","family":"Kawkitinarong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirapon June","family":"Ohata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5199-7440","authenticated-orcid":true,"given":"Gompol","family":"Suwanpimolkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"pone.0273027.ref001","volume-title":"Global Tuberculosis report","author":"World Health Organization","year":"2019"},{"issue":"2","key":"pone.0273027.ref002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/jama.1995.03530020061033","article-title":"Risk factors for tuberculosis in HIV-infected persons. 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The Gruppo Italiano di Studio Tubercolosi e AIDS (GISTA)","volume":"274","author":"G Antonucci","year":"1995","journal-title":"JAMA"},{"issue":"5 Pt 1","key":"pone.0273027.ref003","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1164\/ajrccm.150.5.7952577","article-title":"The epidemiology of tuberculosis in gold miners with silicosis","volume":"150","author":"RL Cowie","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0273027.ref004","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/oxfordjournals.epirev.a036046","article-title":"Epidemiology of tuberculosis in the United States","volume":"11","author":"HL Rieder","year":"1989","journal-title":"Epidemiol Rev"},{"key":"pone.0273027.ref005","doi-asserted-by":"crossref","first-page":"828939","DOI":"10.1155\/2013\/828939","article-title":"Risk factors for tuberculosis","volume":"2013","author":"P Narasimhan","year":"2013","journal-title":"Pulm Med"},{"issue":"12","key":"pone.0273027.ref006","doi-asserted-by":"crossref","first-page":"e494","DOI":"10.1371\/journal.pmed.0030494","article-title":"Tuberculosis among health-care workers in low- and middle-income countries: a systematic review","volume":"3","author":"R Joshi","year":"2006","journal-title":"PLoS Med"},{"issue":"3","key":"pone.0273027.ref007","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3201\/eid1703.100947","article-title":"Tuberculosis among health care workers","volume":"17","author":"I Baussano","year":"2011","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"pone.0273027.ref008","doi-asserted-by":"crossref","first-page":"214","DOI":"10.7883\/yoken.JJID.2017.274","article-title":"Tuberculosis among Healthcare Workers at Chiang Mai University Hospital, Thailand: Clinical and Microbiological Characteristics and Treatment Outcomes","volume":"71","author":"J Inchai","year":"2018","journal-title":"Jpn J Infect Dis"},{"issue":"11","key":"pone.0273027.ref009","first-page":"1253","article-title":"Tuberculosis among health care workers at King Chulalongkorn Memorial Hospital, 1988\u20132002","volume":"9","author":"W Jiamjarasrangsi","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"issue":"3","key":"pone.0273027.ref010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.29024\/aogh.2304","article-title":"Incidence of Newly Diagnosed Tuberculosis among Healthcare Workers in a Teaching Hospital, Thailand","volume":"84","author":"P Pongwittayapanu","year":"2018","journal-title":"Ann Glob Health"},{"issue":"12","key":"pone.0273027.ref011","doi-asserted-by":"crossref","first-page":"e0145047","DOI":"10.1371\/journal.pone.0145047","article-title":"Tuberculosis in Healthcare Workers: A Matched Cohort Study in Taiwan","volume":"10","author":"SC Pan","year":"2015","journal-title":"PLoS One"},{"key":"pone.0273027.ref012","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1186\/1471-2458-14-891","article-title":"Tuberculosis among health care workers in KwaZulu-Natal, South Africa: a retrospective cohort analysis","volume":"14","author":"C. Tudor","year":"2014","journal-title":"BMC Public Health"},{"issue":"1","key":"pone.0273027.ref013","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1186\/s12913-016-1601-5","article-title":"The epidemiology of tuberculosis in health care workers in South Africa: a systematic review","volume":"16","author":"L Grobler","year":"2016","journal-title":"BMC Health Serv Res"},{"issue":"6","key":"pone.0273027.ref014","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1017\/ice.2019.76","article-title":"Tuberculosis among healthcare personnel, United States, 2010\u20132016","volume":"40","author":"T Mongkolrattanothai","year":"2019","journal-title":"Infect Control Hosp Epidemiol"},{"key":"pone.0273027.ref015","unstructured":"National Tuberculosis control Program Guideline, Thailand 2018: Pediatric Infectious Disease Society of Thailand; [June 3, 2021]. Available from: https:\/\/www.pidst.or.th\/A641.html?action=download&file=750_NationTBguideline2018.pdf."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T17:40:59Z","timestamp":1661362859000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273027"}},"subtitle":[],"editor":[{"given":"Frederick","family":"Quinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0273027","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]}}}