{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:47:25Z","timestamp":1790700445480,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Council for Scientific and Technological Development","award":["CNPq #409707\/2016-3"],"award-info":[{"award-number":["CNPq #409707\/2016-3"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>The risk of malnutrition is an important predictor of functional capacity in the elderly population. However, whether malnutrition is associated with functional capacity in patients with peripheral artery disease (PAD) is poorly known.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To analyse the association between the risk of malnutrition and functional capacity in patients with PAD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This cross-sectional study included 135 patients with PAD of both genders, \u226550 years old, with symptomatic PAD (Rutherford stage I to III) in one or both limbs and with ankle-brachial index \u22640.90. The risk of malnutrition was assessed by the short form of the Mini Nutritional Assessment-Short Form and patients were classified as having normal nutritional status (n = 92) and at risk of malnutrition (n = 43). Functional capacity was objectively assessed using the six-minute walking test (6MWT, absolute maximal distance and relativized and expressed as a percentage of health subjects), short-physical performance battery (SPPB, balance, gait speed and the sit and stand test) and the handgrip test, and subjectively, using the Walking Impairment Questionnaire and Walking Estimated-Limitation Calculated by History. The association between the risk of malnutrition and functional capacity was analysed using bivariate and multivariate logistic regression adjustments for gender, age, ankle-brachial index, body mass index, use of statins, coronary arterial disease and stroke. For all statistical analyses, significance was accepted at p&lt;0.05.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Thirty-two per cent of our patients were classified with a risk of malnutrition. The risk of malnutrition was associated with the absolute 6MWT total distance (OR = 0.994, P = 0.031) relative 6MWT total distance (OR = 0.971, P = 0.038), lowest SPPB total score (OR = 0.682, P = 0.011), sit and stand (OR = 1.173, P = 0.003) and usual 4-meter walk test (OR = 1.757, P = 0.034).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In patients with PAD, the risk of malnutrition was associated with objective measurements of functional capacity.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0273051","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:22:10Z","timestamp":1662751330000},"page":"e0273051","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between the risk of malnutrition and functional capacity in patients with peripheral arterial disease: A cross-sectional study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6811-7104","authenticated-orcid":true,"given":"Juliana","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-3433","authenticated-orcid":true,"given":"Marilia A.","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lcio","family":"Kanegusuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Longano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael M.","family":"Ritti-Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-8852","authenticated-orcid":true,"given":"Gabriel Grizzo","family":"Cucato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"issue":"4","key":"pone.0273051.ref001","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-0034-1393976","article-title":"Overview of classification systems in peripheral artery disease","volume":"31","author":"RL Hardman","year":"2014","journal-title":"Semin Intervent Radiol"},{"issue":"2","key":"pone.0273051.ref002","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-0031-1278244","article-title":"Peripheral arterial disease: Epidemiology, natural history, diagnosis and treatment","volume":"16","author":"G Dhaliwal","year":"2007","journal-title":"Int J Angiol"},{"issue":"3","key":"pone.0273051.ref003","first-page":"410","article-title":"Physical activity levels in peripheral artery disease patients","volume":"113","author":"AM Gerage","year":"2019","journal-title":"Arq Bras Cardiol"},{"issue":"6","key":"pone.0273051.ref004","first-page":"653","article-title":"Association between fatigue and functional capacity with intermittent claudication","volume":"68","author":"LC Batista","year":"2015","journal-title":"Rev Bras Enferm Bras Enferm"},{"issue":"1","key":"pone.0273051.ref005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1358863X07084911","article-title":"The impact of peripheral arterial disease on health-related quality of life in the Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources for Survival (PARTNERS) Program","volume":"13","author":"JG Regensteiner","year":"2008","journal-title":"Vasc Med"},{"issue":"3","key":"pone.0273051.ref006","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/0003319710384395","article-title":"Dietary intake of participants with peripheral artery disease and claudication","volume":"62","author":"AW Gardner","year":"2011","journal-title":"Angiology"},{"issue":"8","key":"pone.0273051.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11081745","article-title":"The baseline nutritional status predicts long-term mortality in patients undergoing endovascular therapy","volume":"11","author":"K Mizobuchi","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"pone.0273051.ref008","first-page":"64","article-title":"Nutritional status of patients admitted to a metropolitan tertiary care vascular surgery unit","volume":"28","author":"J Thomas","year":"2019","journal-title":"Asia Pac J Clin Nutr"},{"issue":"9","key":"pone.0273051.ref009","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s12603-009-0214-7","article-title":"Validation of the Mini Nutritional Assessment short-form (MNA\u00ae-SF): A practical tool for identification of nutritional status","volume":"13","author":"MJ Kaiser","year":"2009","journal-title":"J Nutr Heal Aging"},{"issue":"6","key":"pone.0273051.ref010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/gerona\/56.6.M366","article-title":"Screening for undernutrition in geriatric practice: Developing the Short-Form Mini-Nutritional Assessment (MNA-SF)","volume":"56","author":"LZ Rubenstein","year":"2001","journal-title":"Journals Gerontol\u2014Ser A Biol Sci Med Sci"},{"issue":"6","key":"pone.0273051.ref011","first-page":"456","article-title":"Overview of the MNA\u00ae\u2014Its history and challenges","volume":"10","author":"B Vellas","year":"2006","journal-title":"J Nutr Heal Aging"},{"issue":"6","key":"pone.0273051.ref012","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s40520-016-0591-9","article-title":"Nutritional status, physical performance and disability in the elderly of the Peruvian Andes","volume":"28","author":"A Tramontano","year":"2016","journal-title":"Aging Clin Exp Res"},{"issue":"1","key":"pone.0273051.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12877-016-0226-1","article-title":"Functional performance, nutritional status, and body composition in ambulant community-dwelling individuals 1\u20133 years after suffering from a cerebral infarction or intracerebral bleeding","volume":"16","author":"B Vahlberg","year":"2016","journal-title":"BMC Geriatr"},{"issue":"1","key":"pone.0273051.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-017-0593-7","article-title":"Assessment of physical activity, capacity and nutritional status in elderly peritoneal dialysis patients","volume":"18","author":"A Cupisti","year":"2017","journal-title":"BMC Nephrol"},{"issue":"4","key":"pone.0273051.ref015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12603-013-0028-5","article-title":"The relationship between nutritional status, functional capacity, and health-related quality of life in older adults with type 2 diabetes: A pilot explanatory study","volume":"17","author":"RM Alfonso-Rosa","year":"2013","journal-title":"J Nutr Heal Aging"},{"issue":"6","key":"pone.0273051.ref016","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/15412555.2017.1386643","article-title":"Nutritional Status of Patients with Chronic Obstructive Pulmonary Disease in Relation to their Physical Performance","volume":"14","author":"Z Matkovic","year":"2017","journal-title":"COPD J Chronic Obstr Pulm Dis"},{"issue":"10","key":"pone.0273051.ref017","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1371\/journal.pmed.0040296","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"4","author":"E Von Elm","year":"2007","journal-title":"PLoS Med"},{"issue":"2","key":"pone.0273051.ref018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1590\/S0041-87812000000200005","article-title":"Predictive value of the ankle-brachial index in the evaluation of intermittent claudication","volume":"55","author":"N Wolosker","year":"2000","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"issue":"9","key":"pone.0273051.ref019","first-page":"1991","article-title":"Corrigendum to: The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment: MOCA: A BRIEF SCREENING TOOL FOR MCI (Journal of the American Geriatrics Society, 53, 4, (695\u2013699), 10.1111\/j.1532-5415.2005.53221.x)","volume":"67","author":"Z. S. Nasreddine","year":"2019","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"pone.0273051.ref020","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1532-5415.1998.tb03804.x","article-title":"The clinical utility of a six-minute walk test in peripheral arterial occlusive disease patients","volume":"46","author":"PS Montgomery","year":"1998","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"pone.0273051.ref021","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1590\/S1413-35552012005000122","article-title":"Reference equations for the six-minute walk distance based on a Brazilian multicenter study","volume":"17","author":"RR Britto","year":"2013","journal-title":"Brazilian J Phys Ther"},{"key":"pone.0273051.ref022","article-title":"Expanding the Use of Six-Minute Walking Test in Patients with Intermittent Claudication","author":"RM Ritti-Dias","year":"2020","journal-title":"Ann Vasc Surg"},{"issue":"2","key":"pone.0273051.ref023","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A Short Physical Performance Battery Assessing Lower Extremity Function: Association With Self-Reported Disability and Prediction of Mortality and Nursing Home Admission Energetic cost of walking in older adults View project IOM committee on cognitive agi","volume":"49","author":"JM Guralnik","year":"1994","journal-title":"Artic J Gerontol"},{"issue":"1","key":"pone.0273051.ref024","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01823246-200819010-00005","article-title":"Research Corner Outcome Measures in Cardiopulmonary Physical Therapy: Short Physical Performance Battery","volume":"19","author":"PT Puthoff","year":"2008","journal-title":"Cardiopulm Phys Ther J"},{"issue":"11","key":"pone.0273051.ref025","first-page":"1","article-title":"Relationship between gait speed and physical function in patients with symptomatic peripheral artery disease","volume":"74","author":"A Correia M de","year":"2019","journal-title":"Clinics"},{"issue":"2","key":"pone.0273051.ref026","first-page":"136","article-title":"Translation and validation of the walking impairment questionnaire in Brazilian subjects with intermittent claudication","volume":"92","author":"RM Ritti-Dias","year":"2009","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"pone.0273051.ref027","first-page":"49","article-title":"Validation of a Brazilian Portuguese version of the walking estimated-limitation calculated by history (WELCH)","volume":"106","author":"GG Cucato","year":"2016","journal-title":"Arq Bras Cardiol"},{"issue":"2","key":"pone.0273051.ref028","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.avsg.2013.01.020","article-title":"Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease","volume":"28","author":"BQ Farah","year":"2014","journal-title":"Ann Vasc Surg"},{"issue":"4","key":"pone.0273051.ref029","doi-asserted-by":"crossref","first-page":"537","DOI":"10.6061\/clinics\/2013(04)16","article-title":"Predictors of walking capacity in peripheral arterial disease patients","volume":"68","author":"BQ Farah","year":"2013","journal-title":"Clinics"},{"key":"pone.0273051.ref030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00508-016-1112-8","article-title":"Nutritional status and its effects on muscle wasting in patients with chronic heart failure: insights from Studies Investigating Co-morbidities Aggravating Heart Failure","volume":"128","author":"M Saitoh","year":"2016","journal-title":"Wien Klin Wochenschr"},{"issue":"4","key":"pone.0273051.ref031","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1161\/CIR.0000000000000623","article-title":"Optimal Exercise Programs for Patients with Peripheral Artery Disease: A Scientific Statement from the American Heart Association","volume":"139","author":"D Treat-Jacobson","year":"2019","journal-title":"Circulation"},{"issue":"243","key":"pone.0273051.ref032","first-page":"27","article-title":"Atherosclerosis: An inflammatory disease","author":"P Libby","year":"2000","journal-title":"Int Congr Symp Ser\u2014R Soc Med"},{"issue":"11","key":"pone.0273051.ref033","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrcardio.2012.117","article-title":"The role of nutrition and body composition in peripheral arterial disease","volume":"9","author":"DP Brostow","year":"2012","journal-title":"Nat Rev Cardiol"},{"issue":"6","key":"pone.0273051.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11061219","article-title":"Nutritional considerations for peripheral arterial disease: A narrative review","volume":"11","author":"CL Delaney","year":"2019","journal-title":"Nutrients"},{"issue":"12","key":"pone.0273051.ref035","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.rmed.2010.05.008","article-title":"Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD","volume":"104","author":"K Sugawara","year":"2010","journal-title":"Respir Med"},{"issue":"5","key":"pone.0273051.ref036","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1358863X12448457","article-title":"Vitamin D status and functional performance in peripheral artery disease","volume":"17","author":"MM McDermott","year":"2012","journal-title":"Vasc Med (United Kingdom)"},{"issue":"3","key":"pone.0273051.ref037","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1475-097X.2002.00423.x","article-title":"Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease","volume":"22","author":"XY Hou","year":"2002","journal-title":"Clin Physiol Funct Imaging"},{"issue":"November","key":"pone.0273051.ref038","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/ATVBAHA.120.313831","article-title":"Skeletal muscle pathology in peripheral artery disease a brief review","author":"MM McDermott","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"pone.0273051.ref039","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1053\/ejvs.2002.1755","article-title":"Patients with chronic critical limb ischaemia have reduced total antioxidant capacity and impaired nutritional status","volume":"24","author":"JI Spark","year":"2002","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"4","key":"pone.0273051.ref040","first-page":"495","article-title":"Comparison between subjective and objective methods to assess functional capacity during clinical treatment in patients with intermittent claudication","volume":"11","author":"GG Cucato","year":"2013","journal-title":"Einstein (Sao Paulo)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:23:03Z","timestamp":1662751383000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273051"}},"subtitle":[],"editor":[{"given":"Yih-Kuen","family":"Jan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0273051","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}