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Specific genetic signals involving the fibroblast growth factor receptor-like 1 (<jats:italic>FGFRL1<\/jats:italic>) gene are related to high blood pressure and bone growth in giraffes. <jats:italic>FGFRL1<\/jats:italic> is associated with cardiovascular system and bone formation. We performed an association study to investigate the role of <jats:italic>FGFRL1<\/jats:italic> in hypertension, osteoporosis, and height determination in humans. In addition, we identified three kinds of phenotypes in fibroblast growth factor (<jats:italic>FGF<\/jats:italic>) genes and examined their association with the <jats:italic>FGFRL1<\/jats:italic> gene. We identified 42 SNPs in the <jats:italic>FGFRL1<\/jats:italic> gene associated with each trait. We then analyzed the potential functional annotation of each SNP. The <jats:italic>FGFRL1<\/jats:italic> gene was found to be associated with height, hypertension, and osteoporosis, consistent with the results of a previous study. In addition, the <jats:italic>FGF2<\/jats:italic>, <jats:italic>FGF4<\/jats:italic>, <jats:italic>FGF10<\/jats:italic>, <jats:italic>FGF18<\/jats:italic>, and <jats:italic>FGF22<\/jats:italic> genes were found to interact with the <jats:italic>FGFRL1<\/jats:italic> gene. Our study suggests that both <jats:italic>FGFRL1<\/jats:italic> and <jats:italic>FGFRL1<\/jats:italic>-related genes may determine the height and the prevalence of osteoporosis and hypertension in the Korean population.<\/jats:p>","DOI":"10.1371\/journal.pone.0273237","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T17:50:20Z","timestamp":1660845020000},"page":"e0273237","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis"],"prefix":"10.1371","volume":"17","author":[{"given":"Hye-Won","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Seok","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-7248","authenticated-orcid":true,"given":"Yong-Bin","family":"Eom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"pone.0273237.ref001","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bone.2013.07.013","article-title":"Association between metabolic syndrome and osteoporosis: a meta-analysis","volume":"57","author":"J Zhou","year":"2013","journal-title":"Bone"},{"key":"pone.0273237.ref002","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7075815","article-title":"Association of Hypertension and Lipid Profile with Osteoporosis","volume":"2020","author":"M Al-Hariri","year":"2020","journal-title":"Scientifica"},{"key":"pone.0273237.ref003","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCRESAHA.118.313220","article-title":"Adherence in hypertension: a review of prevalence, risk factors, impact, and management","volume":"124","author":"M Burnier","year":"2019","journal-title":"Circ Res"},{"key":"pone.0273237.ref004","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II\u2013induced hypertension and vascular dysfunction","volume":"204","author":"TJ Guzik","year":"2007","journal-title":"Exp Med"},{"key":"pone.0273237.ref005","doi-asserted-by":"crossref","first-page":"100047","DOI":"10.1016\/j.medntd.2020.100047","article-title":"Hypertension and Osteoporosis: Common Pathophysiological Mechanisms","author":"L Do Carmo","year":"2020","journal-title":"Medicine in Novel Technology and Devices"},{"key":"pone.0273237.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12891-021-04124-9","article-title":"Hypertension is associated with osteoporosis: a case-control study in Chinese postmenopausal women","volume":"22","author":"H Chai","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0273237.ref007","first-page":"1","article-title":"Association between metabolic syndrome and osteoporosis in Taiwanese middle-aged and elderly participants","volume":"13","author":"HH Lin","year":"2018","journal-title":"Arch Osteoporos"},{"key":"pone.0273237.ref008","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s00198-017-4050-z","article-title":"Meta-analysis of hypertension and osteoporotic fracture risk in women and men","volume":"28","author":"C Li","year":"2017","journal-title":"Osteoporos Int"},{"key":"pone.0273237.ref009","doi-asserted-by":"crossref","first-page":"eabe9459","DOI":"10.1126\/sciadv.abe9459","article-title":"A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe","volume":"7","author":"C Liu","year":"2021","journal-title":"Sci Adv"},{"key":"pone.0273237.ref010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/dmm.002287","article-title":"Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice","volume":"2","author":"C Catela","year":"2009","journal-title":"Dis Model Mech"},{"key":"pone.0273237.ref011","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00018-010-0576-3","article-title":"Biology of FGFRL1, the fifth fibroblast growth factor receptor","volume":"68","author":"B. 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