{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:43:09Z","timestamp":1790181789263,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Aims<\/jats:title>\n<jats:p>The purpose of this study was to investigate the effects of cardiac rehabilitation (CR) on elderly patients with Chronic heart failure (CHF) by literature search and meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We conducted an electronic search on PubMed, Cochrane Library, Embase, CNKI, Wanfang, and VIP database platforms. The search period was from the establishment of the database to November 2021 for randomized controlled studies (RCTs) related to the effects of CR on elderly patients with CHF. The RevMan 5.4 was used for meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>This study included 16 articles involving a total of 1782 patients, including 892 in the CR group and 890 in the control group. Meta-analysis showed that compared with conventional interventions, CR increased left ventricular ejection fraction in elderly patients with CHF [mean difference (MD):5.73,95% confidence interval (CI):2.05 to 9.40,Z = 3.05,P = 0.002], and decreased left ventricular end-diastolic diameter in elderly patients with CHF (MD:-4.82,95%CI:-7.49 to 15,Z = 3.54,P = 0.0004), increased the 6-minute walk test distance (MD:62.66,95% CI:44.40 to 80.92,Z = 6.72,P&lt;0.00001), decreased the rehospitalization rate (OR:0.32,95%) CI: 0.21 0.49, Z = 5.33, P &lt; 0.000001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>CR can improve cardiac function, prognosis and reduce rehospitalization rate of elderly patients with CHF.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0273251","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T17:35:19Z","timestamp":1661448919000},"page":"e0273251","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of cardiac rehabilitation on elderly patients with Chronic heart failure: A meta-analysis and systematic review"],"prefix":"10.1371","volume":"17","author":[{"given":"Zhuang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youbo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-5070","authenticated-orcid":true,"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"issue":"10","key":"pone.0273251.ref001","first-page":"760","article-title":"Chinese Heart Failure Diagnosis and Treatment Guidelines 2018.","volume":"46","author":"YL Hua Wang","year":"2018"},{"issue":"2","key":"pone.0273251.ref002","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.mayocp.2016.12.009","article-title":"Observations and Reflections on the Burden of Hospitalizations for Heart Failure.","volume":"92","author":"HO Ventura","year":"2017","journal-title":"Mayo Clinic proceedings"},{"issue":"4","key":"pone.0273251.ref003","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00005082-200607000-00007","article-title":"Rationale and design of the National Benchmarking and Evidence-based National Clinical Guidelines for CHF Management Programs Study.","volume":"21","author":"A Driscoll","year":"2006","journal-title":"The Journal of cardiovascular nursing"},{"issue":"4","key":"pone.0273251.ref004","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/NHH.0000000000000777","article-title":"CHF Treatment With the Left Ventricular Assist Device.","volume":"37","author":"T Capriotti","year":"2019","journal-title":"Home healthcare now"},{"issue":"7","key":"pone.0273251.ref005","doi-asserted-by":"crossref","first-page":"e665","DOI":"10.1016\/S2214-109X(17)30196-1","article-title":"Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER-CHF) prospective cohort study.","volume":"5","author":"H Dokainish","year":"2017","journal-title":"The Lancet Global health"},{"issue":"01","key":"pone.0273251.ref006","first-page":"1","article-title":"China Cardiovascular Disease Report 2017","volume":"33","author":"RG Weiwei Chen","year":"2018","journal-title":"Chinese Circulation Journal"},{"key":"pone.0273251.ref007","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijcard.2021.09.004","article-title":"Cancer and cardiovascular disease: The impact of cardiac rehabilitation and cardiorespiratory fitness on survival.","volume":"343","author":"T Williamson","year":"2021","journal-title":"Int J Cardiol"},{"issue":"2","key":"pone.0273251.ref008","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCRESAHA.117.305205","article-title":"Exercise and the cardiovascular system: clinical science and cardiovascular outcomes","volume":"117","author":"CJ Lavie","year":"2015","journal-title":"Circulation research"},{"key":"pone.0273251.ref009","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/5584_2018_144","article-title":"Physical Training and CR in Heart Failure Patients","volume":"1067","author":"C. de Gregorio","year":"2018","journal-title":"Advances in experimental medicine and biology"},{"issue":"5","key":"pone.0273251.ref010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.","volume":"8","author":"D Moher","year":"2010","journal-title":"International journal of 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Kang","year":"2017"},{"issue":"18","key":"pone.0273251.ref015","article-title":"Effects of CR exercise therapy on CHF with coronary heart disease in the elderly.","volume":"7","author":"LL Yihua Hu","year":"2020","journal-title":"Electronic Journal of Clinical Medicine"},{"issue":"09","key":"pone.0273251.ref016","article-title":"Effects of CR exercise on cardiac function and adverse psychological mood in elderly patients with CHF.","volume":"40","author":"FY Kehua Fang","year":"2020","journal-title":"Clinical Medicine"},{"issue":"17","key":"pone.0273251.ref017","article-title":"Observation on the efficacy of CR exercise in the treatment of elderly CHF.","volume":"28","author":"ZU LFYYKM","year":"2018","journal-title":"China Health Nutrition"},{"issue":"08","key":"pone.0273251.ref018","first-page":"11","article-title":"Observation on the effect of CR exercise therapy on CHF with coronary heart disease in the elderly","volume":"10","author":"F. Shen YX","year":"2019","journal-title":"Massage and Rehabilitation Medicine"},{"issue":"25","key":"pone.0273251.ref019","article-title":"Clinical effect of CR on the safety of elderly patients with CHF","volume":"13","author":"Quanlin Zou Liping Liu Tl","year":"2020","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"issue":"35","key":"pone.0273251.ref020","article-title":"Interpretation of the effect of CR exercise therapy on CHF with coronary heart disease in the elderly","volume":"6","author":"LJ JIN","year":"2019","journal-title":"Diet and Health Care"},{"issue":"10","key":"pone.0273251.ref021","first-page":"880","article-title":"Clinical efficacy of cardiopulmonary integrated CR in elderly patients with CHF China Cardiovascular Research.","volume":"18","author":"LZ Haipeng Hui","year":"2020"},{"issue":"4","key":"pone.0273251.ref022","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/HJR.0b013e328334ea56","article-title":"Can a heart failure-specific CR program decrease hospitalizations and improve outcomes in high-risk patients?","volume":"17","author":"PM Davidson","year":"2010","journal-title":"European journal of cardiovascular prevention and rehabilitation: official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and CR and Exercise Physiology."},{"issue":"3","key":"pone.0273251.ref023","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejheart.2004.10.004","article-title":"Randomised controlled trial of CR in elderly patients with heart failure","volume":"7","author":"J Austin","year":"2005","journal-title":"European journal of heart failure"},{"issue":"25","key":"pone.0273251.ref024","article-title":"Effects of group positive psychological intervention combined with standardized first-stage exercise rehabilitation on resilience and quality of life in elderly patients with CHF","volume":"5","author":"ZC Fei Ding","year":"2020","journal-title":"Clinical Medicine Research and Practice"},{"issue":"2","key":"pone.0273251.ref025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/HJR.0b013e3282f10e87","article-title":"Five-year follow-up findings from a randomized controlled trial of CR for heart failure","volume":"15","author":"J Austin","year":"2008","journal-title":"European journal of cardiovascular prevention and rehabilitation: official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and CR and Exercise Physiology."},{"issue":"3","key":"pone.0273251.ref026","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/2047487318806358","article-title":"The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: The REACH-HF multicentre randomized controlled trial.","volume":"26","author":"HM Dalal","year":"2019","journal-title":"European journal of preventive cardiology"},{"issue":"3","key":"pone.0273251.ref027","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1388-9842(00)00141-0","article-title":"More \u2019malignant\u2019 than cancer? Five-year survival following a first admission for heart failure.","volume":"3","author":"S Stewart","year":"2001","journal-title":"European journal of heart failure"},{"issue":"12","key":"pone.0273251.ref028","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association","volume":"137","author":"EJ Benjamin","year":"2018","journal-title":"Circulation"},{"issue":"01","key":"pone.0273251.ref029","first-page":"31","article-title":"Investigation on healthy lifestyle of the elderly.","volume":"25","author":"HL Xiaohua Shen","year":"2013","journal-title":"Zhejiang Preventive Medicine"},{"issue":"3","key":"pone.0273251.ref030","first-page":"79","article-title":"Features of the structural and functional condition of the myocardium in patients with chronic kidney disease and CHF.","volume":"11","author":"DS Frolov","year":"2019"},{"key":"pone.0273251.ref031","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijcard.2019.03.063","article-title":"The analysis of left atrial function predicts the severity of functional impairment in CHF: The FLASH multicenter study.","volume":"286","author":"M Cameli","year":"2019","journal-title":"International journal of cardiology"},{"issue":"12","key":"pone.0273251.ref032","first-page":"1411","article-title":"The value of 6-min walking test combined with plasma N-terminal precursor brain natriuretic peptide in evaluating the prognosis of patients with CHF","volume":"39","author":"CX Yulong Wang","year":"2020","journal-title":"Chinese journal of gerontology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T17:36:02Z","timestamp":1661448962000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273251"}},"subtitle":[],"editor":[{"given":"Chim C.","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0273251","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,25]]}}}