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From 28 to 92 days of age, weaned male Wistar rats were given a diet with low content and poor-quality protein, and low lipid, without vitamin supplementation, which mimics the diets consumed in impoverished regions worldwide. We measured food, energy and Na<jats:sup>+<\/jats:sup> ingestion, together with urinary Na<jats:sup>+<\/jats:sup> excretion, Na<jats:sup>+<\/jats:sup> density (Na<jats:sup>+<\/jats:sup> intake\/energy intake), plasma Na<jats:sup>+<\/jats:sup> concentration, SBP, and renal proximal tubule Na<jats:sup>+<\/jats:sup>-transporting ATPases. Undernourished rats aged 92 days had only one-third of the control body mass, lower plasma albumin, higher SBP, higher energy intake, and higher positive Na<jats:sup>+<\/jats:sup> balance accompanied by decreased plasma Na<jats:sup>+<\/jats:sup> concentration. Losartan or Ang-(3\u20134) normalized SBP, and the combination of the 2 substances induced an accentuated negative Na<jats:sup>+<\/jats:sup> balance as a result of strong inhibition of Na<jats:sup>+<\/jats:sup> ingestion. Na<jats:sup>+<\/jats:sup> density in undernourished rats was higher than in control, irrespective of the treatment, and they had downregulated (Na<jats:sup>+<\/jats:sup>+K<jats:sup>+<\/jats:sup>)ATPase and upregulated Na<jats:sup>+<\/jats:sup>-ATPase in proximal tubule cells, which returned to control levels after Losartan or Ang-(3\u20134). We conclude that Na<jats:sup>+<\/jats:sup> density, not only Na<jats:sup>+<\/jats:sup> ingestion, plays a central role in the pathophysiology of elevated SBP in chronically undernourished rats. The observations that Losartan and Ang-(3\u20134) normalized SBP together with negative Na<jats:sup>+<\/jats:sup> balance give support to the proposal that Ang II\u21d2AT<jats:sub>1<\/jats:sub>R and Ang II\u21d2AT<jats:sub>2<\/jats:sub>R axes have opposite roles within the renin-angiotensin-aldosterone system of undernourished juvenile rats.<\/jats:p>","DOI":"10.1371\/journal.pone.0273385","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T17:31:10Z","timestamp":1660930270000},"page":"e0273385","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Angiotensin-(3\u20134) normalizes the elevated arterial blood pressure and abnormal Na+\/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors"],"prefix":"10.1371","volume":"17","author":[{"given":"Amaury","family":"Pereira-Ac\u00e1cio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o P. 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