{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:33:57Z","timestamp":1788640437216,"version":"build-2803163510"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjectives<\/jats:title>\nThis study aimed to evaluate the clinical and radiographic outcomes of early implant placement and functional loading in maxillary sinus floor augmentation (MSFA) using recombinant human bone morphogenetic protein 2\/hydroxyapatite (rhBMP-2\/HA) and to compare these outcomes with those of the conventional protocol in MSFA using deproteinized bovine bone (DBB).<\/jats:p>\n<\/jats:sec>\n\nMaterials and methods<\/jats:title>\nThe rhBMP-2\/HA and DBB groups consisted of 14 and 13 patients who underwent MSFA with BMP and DBB, respectively. After placement of 22 implants and 21 implants in the rhBMP-2\/HA and DBB groups, respectively, abutment connections were performed 3 months after implant placement for the rhBMP-2\/HA group and 6 months after implant placement for the DBB group. Changes in grafted sinus height (GSH), marginal bone loss (MBL), and implant stability were evaluated up to one year after functional loading.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nSurvival rates for the rhBMP-2\/HA and DBB groups after one year of functional loading were 90.9% and 90.5%, respectively. Both groups exhibited no significant time-course changes in GSH until one year of functional loading (rhBMP-2\/HA, p<\/jats:italic> = 0.124; DBB, p<\/jats:italic> = 0.075). Although significant MBL occurred after one year of functional loading for both groups (rhBMP-2\/HA, p<\/jats:italic> < 0.001; DBB, p<\/jats:italic> < 0.001), there were no significant differences in time-course changes in MBL between the two groups (p<\/jats:italic> = 0.450). The mean implant stability quotient values in the rhBMP-2\/HA and DBB groups were 75.3 and 75.4 after one year of functional loading, respectively, and there were no significant differences between the two groups (p<\/jats:italic> = 0.557).<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nMSFA using rhBMP-2\/HA allowed implant rehabilitation with early implant placement and functional loading and led to a comparable survival rate and implant stability after 1 year of functional loading with acceptable MBL and stable maintenance of GSH compared to the MSFA using DBB with 6 months of healing after implant placement.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0273399","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T17:45:31Z","timestamp":1661449531000},"page":"e0273399","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical and radiographic outcomes of dental implant after maxillary sinus floor augmentation with rhBMP-2\/hydroxyapatite compared to deproteinized bovine bone"],"prefix":"10.1371","volume":"17","author":[{"given":"Jeong Joon","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-7072","authenticated-orcid":true,"given":"Eun-Hyuk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-7305","authenticated-orcid":true,"given":"Hoon Joo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Jung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"issue":"3","key":"pone.0273399.ref001","first-page":"639","article-title":"Five-year treatment outcomes with four types of implants in the posterior maxilla and mandible in partially edentulous patients: a retrospective study.","volume":"26","author":"Y Ozkan","year":"2011","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"1","key":"pone.0273399.ref002","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/cid.12077","article-title":"Long-term outcomes for the treatment of atrophic posterior maxilla: a systematic review of literature.","volume":"17","author":"S Corbella","year":"2015","journal-title":"Clin Implant Dent Relat 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