{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:32:12Z","timestamp":1790649132676,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p><jats:italic>Toxoplasma gondii<\/jats:italic> is one of the world\u2019s most common parasites. Primary infection of the mother during pregnancy can lead to transmission to the fetus with risks of brain and eye lesions, which may cause lifelong disabilities. France instituted a national program based on monthly retesting of susceptible pregnant women to reduce the number of severe cases through prompt antenatal and postnatal treatment and follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the ability of the French prenatal retesting program to reduce the lifetime costs of congenital toxoplasmosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We measured and then compared the costs and benefits of screening vs. not screening using decision-tree modelling. It included direct and indirect costs to society of treatment and care, and the lifetime lost earnings of children and caregivers. A probabilistic sensitivity analysis was carried out.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Findings<\/jats:title>\n<jats:p>Total lifetime costs per live born child identified as congenitally infected were estimated to be \u20ac444 for those identified through prenatal screening vs \u20ac656 for those who were not screened. Estimates were robust to changes in all costs of diagnosis, treatment, and sequelae.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Interpretation<\/jats:title>\n<jats:p>Screening for the prevention of the congenital <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic> infection in France is cost saving at \u20ac212 per birth. Compared with no screening, screening every pregnant woman in France for toxoplasmosis in 2020 would have saved the country \u20ac148 million in addition to reducing or eliminating the devastating physical and emotional suffering caused by <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic>. Our findings reinforce the conclusions of other decision-analytic modelling of prenatal toxoplasmosis screening.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0273781","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T17:31:21Z","timestamp":1667583081000},"page":"e0273781","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevention of congenital toxoplasmosis in France using prenatal screening: A decision-analytic economic model"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7661-3079","authenticated-orcid":true,"given":"Larry","family":"Sawers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Wallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mandelbrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Villena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Stillwaggon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-9479","authenticated-orcid":true,"given":"Fran\u00e7ois","family":"Kieffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"pone.0273781.ref001","first-page":"949","volume-title":"Remington and Klein\u2019s Infectious Diseases of the fetus and Newborn Infant","author":"F Peyron","year":"2016","edition":"8"},{"issue":"9556","key":"pone.0273781.ref002","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0140-6736(07)60072-5","article-title":"SYROCOT\u2014Systematic Review on Congenital Toxoplasmosis Study Group. 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