{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:38:49Z","timestamp":1792651129151,"version":"4.5.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01 AI098670"],"award-info":[{"award-number":["P01 AI098670"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1081737"],"award-info":[{"award-number":["OPP1081737"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010201","name":"U.S. Army Medical Research Institute of Infectious Diseases","doi-asserted-by":"publisher","award":["S0520_15_LI and S0572_17_LI"],"award-info":[{"award-number":["S0520_15_LI and S0572_17_LI"]}],"id":[{"id":"10.13039\/100010201","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014035","name":"Armed Forces Health Surveillance Branch","doi-asserted-by":"publisher","award":["ProMIS ID: 20160390169, P0090_17_N6_1.1.1, P0106_18_N6_01.01, and P0143_19_N6"],"award-info":[{"award-number":["ProMIS ID: 20160390169, P0090_17_N6_1.1.1, P0106_18_N6_01.01, and P0143_19_N6"]}],"id":[{"id":"10.13039\/100014035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Current knowledge of dengue virus (DENV) transmission provides only a partial understanding of a complex and dynamic system yielding a public health track record that has more failures than successes. An important part of the problem is that the foundation for contemporary interventions includes a series of longstanding, but untested, assumptions based on a relatively small portion of the human population; i.e., people who are convenient to study because they manifest clinically apparent disease. Approaching dengue from the perspective of people with overt illness has produced an extensive body of useful literature. It has not, however, fully embraced heterogeneities in virus transmission dynamics that are increasingly recognized as key information still missing in the struggle to control the most important insect-transmitted viral infection of humans. Only in the last 20 years have there been significant efforts to carry out comprehensive longitudinal dengue studies. This manuscript provides the rationale and comprehensive, integrated description of the methodology for a five-year longitudinal cohort study based in the tropical city of Iquitos, in the heart of the Peruvian Amazon. Primary data collection for this study was completed in 2019. Although some manuscripts have been published to date, our principal objective here is to support subsequent publications by describing in detail the structure, methodology, and significance of a specific research program. Our project was designed to study people across the entire continuum of disease, with the ultimate goal of quantifying heterogeneities in human variables that affect DENV transmission dynamics and prevention. Because our study design is applicable to other <jats:italic>Aedes<\/jats:italic> transmitted viruses, we used it to gain insights into Zika virus (ZIKV) transmission when during the project period ZIKV was introduced and circulated in Iquitos. Our prospective contact cluster investigation design was initiated by detecttion of a person with a symptomatic DENV infection and then followed that person\u2019s immediate contacts. This allowed us to monitor individuals at high risk of DENV infection, including people with clinically inapparent and mild infections that are otherwise difficult to detect. We aimed to fill knowledge gaps by defining the contribution to DENV transmission dynamics of (1) the understudied majority of DENV-infected people with inapparent and mild infections and (2) epidemiological, entomological, and socio-behavioral sources of heterogeneity. By accounting for factors underlying variation in each person\u2019s contribution to transmission we sought to better determine the type and extent of effort needed to better prevent virus transmission and disease.<\/jats:p>","DOI":"10.1371\/journal.pone.0273798","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:50:38Z","timestamp":1675363838000},"page":"e0273798","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantifying heterogeneities in arbovirus transmission: Description of the rationale and methodology for a prospective longitudinal study of dengue and Zika virus transmission in Iquitos, Peru (2014\u20132019)"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-5984","authenticated-orcid":true,"given":"Amy C.","family":"Morrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Paz-Soldan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo M.","family":"Vazquez-Prokopec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Lambrechts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Elson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helvio","family":"Astete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Briesemeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-0263","authenticated-orcid":true,"given":"Mariana","family":"Leguia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanya C.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-2612","authenticated-orcid":true,"given":"Anna B.","family":"Kawiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Alex","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alun L.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Waller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Hontz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Stoddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-346X","authenticated-orcid":true,"given":"Christopher M.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel","family":"Kitron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-6848","authenticated-orcid":true,"given":"Alan L.","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Proyecto Dengue Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"pone.0273798.ref001","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1371\/journal.pmed.0050068","article-title":"Defining challenges and proposing solutions for control of the virus vector Aedes aegypti.","volume":"5","author":"AC Morrison","year":"2008","journal-title":"PLoS Med"},{"key":"pone.0273798.ref002","doi-asserted-by":"crossref","first-page":"e670","DOI":"10.1371\/journal.pntd.0000670","article-title":"Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission.","volume":"4","author":"AC Morrison","year":"2010","journal-title":"PLoS Negl Trop Dis."},{"key":"pone.0273798.ref003","first-page":"1","article-title":"Prospective cohort studies of dengue viral transmission and severity of disease","volume":"338","author":"TP Endy","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"pone.0273798.ref004","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1073\/pnas.1213349110","article-title":"House-to-house human movement drives dengue virus transmission","volume":"110","author":"ST Stoddard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0273798.ref005","article-title":"Effects of pre-existing DENV antibody on the occurrence of symptomatic illness associated with novel DENV-4 infection","author":"S Olkowski","year":"2011","journal-title":"American Society of Tropical Medicine and Hygeine"},{"key":"pone.0273798.ref006","doi-asserted-by":"crossref","first-page":"e58802","DOI":"10.1371\/journal.pone.0058802","article-title":"Using GPS technology to quantify human mobility, dynamic contacts and infectious disease dynamics in a resource-poor urban environment.","volume":"8","author":"GM Vazquez-Prokopec","year":"2013","journal-title":"PLoS One."},{"key":"pone.0273798.ref007","first-page":"11","article-title":"Theory and data for simulating fine-scale human movement in an urban environment.","author":"TA Perkins","year":"2014","journal-title":"J R Soc Interface."},{"key":"pone.0273798.ref008","doi-asserted-by":"crossref","first-page":"e2888","DOI":"10.1371\/journal.pntd.0002888","article-title":"Strengths and weaknesses of Global Positioning System (GPS) data-loggers and semi-structured interviews for capturing fine-scale human mobility: findings from Iquitos, Peru.","volume":"8","author":"VA Paz-Soldan","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref009","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4269\/ajtmh.2010.09-0496","article-title":"Assessing and maximizing the acceptability of global positioning system device use for studying the role of human movement in dengue virus transmission in Iquitos, Peru","volume":"82","author":"VA Paz-Soldan","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0273798.ref010","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.3201\/eid2609.191472","article-title":"Heterogeneity of dengue illness in community-based prospective study, Iquitos, Peru","volume":"26","author":"WH Elson","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"pone.0273798.ref011","doi-asserted-by":"crossref","first-page":"e0007756","DOI":"10.1371\/journal.pntd.0007756","article-title":"Dengue illness impacts daily human mobility patterns in Iquitos, Peru.","volume":"13","author":"KL Schaber","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref012","doi-asserted-by":"crossref","first-page":"e1008627","DOI":"10.1371\/journal.pcbi.1008627","article-title":"Disease-driven reduction in human mobility influences human-mosquito contacts and dengue transmission dynamics.","volume":"17","author":"KL Schaber","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"pone.0273798.ref013","doi-asserted-by":"crossref","first-page":"e0008477","DOI":"10.1371\/journal.pntd.0008477","article-title":"Measuring health related quality of life for dengue patients in Iquitos, Peru.","volume":"14","author":"WH Elson","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref014","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4269\/ajtmh.2009.80.656","article-title":"Comparison of two active surveillance programs for the detection of clinical dengue cases in Iquitos, Peru","volume":"80","author":"C Rocha","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0273798.ref015","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"pone.0273798.ref016","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"DW Vaughn","year":"2000","journal-title":"J Infect Dis"},{"key":"pone.0273798.ref017","doi-asserted-by":"crossref","first-page":"e1000171","DOI":"10.1371\/journal.pmed.1000171","article-title":"A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model.","volume":"6","author":"DH Libraty","year":"2009","journal-title":"PLoS Med"},{"key":"pone.0273798.ref018","volume-title":"Dengue and dengue hemorrhagic fever in the Americas: guidelines for prevention and control","author":"Pan American Sanitary Bureau","year":"1994"},{"key":"pone.0273798.ref019","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0966-842X(01)02288-0","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century","volume":"10","author":"DJ Gubler","year":"2002","journal-title":"Trends Microbiol"},{"key":"pone.0273798.ref020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.ento.53.103106.093326","article-title":"Dengue virus-mosquito interactions","volume":"53","author":"SB Halstead","year":"2008","journal-title":"Annu Rev Entomol"},{"key":"pone.0273798.ref021","doi-asserted-by":"crossref","first-page":"e1760","DOI":"10.1371\/journal.pntd.0001760","article-title":"Refining the global spatial limits of dengue virus transmission by evidence-based consensus.","volume":"6","author":"OJ Brady","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref022","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S1473-3099(16)00026-8","article-title":"The global burden of dengue: an analysis from the Global Burden of Disease Study 2013","volume":"16","author":"JD Stanaway","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"pone.0273798.ref023","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","article-title":"Global spread of dengue virus types: mapping the 70 year history","volume":"22","author":"JP Messina","year":"2014","journal-title":"Trends Microbiol"},{"key":"pone.0273798.ref024","doi-asserted-by":"crossref","first-page":"e1004031","DOI":"10.1371\/journal.ppat.1004031","article-title":"First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies","volume":"10","author":"JKW Ng","year":"2014","journal-title":"PLoS Pathog"},{"key":"pone.0273798.ref025","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4269\/ajtmh.1989.40.571","article-title":"Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up. Charles Franklin Craig Lecture","volume":"40","author":"DJ Gubler","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0273798.ref026","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pt.2015.04.015","article-title":"Evidence-based vector control? Improving the quality of vector control trials","volume":"31","author":"AL Wilson","year":"2015","journal-title":"Trends Parasitol"},{"key":"pone.0273798.ref027","doi-asserted-by":"crossref","first-page":"e0004551","DOI":"10.1371\/journal.pntd.0004551","article-title":"Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis","volume":"10","author":"LR Bowman","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"key":"pone.0273798.ref028","first-page":"32","volume-title":"Institute of Medicine (U.S.). Forum on Microbial Threats., editors. Vector-borne diseases: understanding the environmental, human health, and ecological connections: workshop summary","author":"TW Scott","year":"2008"},{"key":"pone.0273798.ref029","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4269\/ajtmh.2005.72.777","article-title":"Early detection of dengue infections using cluster sampling around index cases","volume":"72","author":"CG Beckett","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0273798.ref030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/aje\/kwf005","article-title":"Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand","volume":"156","author":"TP Endy","year":"2002","journal-title":"Am J Epidemiol"},{"key":"pone.0273798.ref031","doi-asserted-by":"crossref","first-page":"e975","DOI":"10.1371\/journal.pntd.0000975","article-title":"Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand.","volume":"5","author":"TP Endy","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref032","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1086\/648592","article-title":"Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua","volume":"201","author":"A Balmaseda","year":"2010","journal-title":"J Infect Dis"},{"key":"pone.0273798.ref033","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nature07084","article-title":"Inapparent infections and cholera dynamics","volume":"454","author":"AA King","year":"2008","journal-title":"Nature"},{"key":"pone.0273798.ref034","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, transmission, diagnosis, and treatment of Coronavirus disease 2019 (COVID-19): A review.","volume":"324","author":"WJ Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"pone.0273798.ref035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4269\/ajtmh.1998.58.287","article-title":"Exploratory space-time analysis of reported dengue cases during an outbreak in Florida, Puerto Rico, 1991\u20131992","volume":"58","author":"AC Morrison","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0273798.ref036","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1371\/journal.pntd.0000787","article-title":"Arboviral etiologies of acute febrile illnesses in Western South America, 2000\u20132007.","volume":"4","author":"BM Forshey","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref037","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3201\/eid1511.090663","article-title":"Dengue virus serotype 4, northeastern Peru, 2008","volume":"15","author":"BM Forshey","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"pone.0273798.ref038","volume-title":"PostgreSQL","author":"PostgreSQL Global Development Group","year":"2020"},{"key":"pone.0273798.ref039","unstructured":"Developers P. PostGIS\u2014Spatial and Geographic Objects for PostgreSQL. [cited 10 Spring 2020]. Available: https:\/\/postgis.net"},{"key":"pone.0273798.ref040","article-title":"QGIS Geographic Information System.","author":"QGIS Development Team","year":"2019","journal-title":"Open Source Geospatial Foundation"},{"key":"pone.0273798.ref041","unstructured":"CommCare by Dimagi. [cited 10 Spring 2020]. Available: https:\/\/www.dimagi.com\/commcare\/"},{"key":"pone.0273798.ref042","article-title":"Django Software Foundation.","year":"2018","journal-title":"2018, Django version #.#."},{"key":"pone.0273798.ref043","article-title":"Efficacy of a spatial repellent for control of Aedes-borne virus transmission: A cluster randomized trial in Iquitos, Peru.","author":"AC Morrison","year":"2021","journal-title":"bioRxiv. medRxiv"},{"key":"pone.0273798.ref044","article-title":"Censos Nacionales 2017: XII De Poblacion, VII de Viviendas y III de communidades indigenas.","author":"INEI","year":"2017","journal-title":"Systema de Consulta de base de datos."},{"key":"pone.0273798.ref045","doi-asserted-by":"crossref","first-page":"e3003","DOI":"10.1371\/journal.pntd.0003003","article-title":"Long-term and seasonal dynamics of dengue in Iquitos, Peru.","volume":"8","author":"ST Stoddard","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref046","doi-asserted-by":"crossref","first-page":"e0006378","DOI":"10.1371\/journal.pntd.0006378","article-title":"Efficacy of Aedes aegypti control by indoor Ultra Low Volume (ULV) insecticide spraying in Iquitos, Peru.","volume":"12","author":"CE Gunning","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref047","doi-asserted-by":"crossref","first-page":"e0006708","DOI":"10.1371\/journal.pntd.0006708","article-title":"\u201cZika is everywhere\u201d: A qualitative exploration of knowledge, attitudes and practices towards Zika virus among women of reproductive age in Iquitos, Peru.","volume":"12","author":"CT Weldon","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref048","unstructured":"[cited 29 Dec 2020]. Available: http:\/\/www.dge.gob.pe\/portal\/docs\/vigilancia\/sala\/2017\/SE33\/zika.pdf"},{"key":"pone.0273798.ref049","author":"INEI","year":"2017","journal-title":"Pobreza"},{"key":"pone.0273798.ref050","doi-asserted-by":"crossref","first-page":"e0007116","DOI":"10.1371\/journal.pntd.0007116","article-title":"Feasibility of feeding Aedes aegypti mosquitoes on dengue virus-infected human volunteers for vector competence studies in Iquitos, Peru.","volume":"13","author":"KC Long","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"pone.0273798.ref051","unstructured":"Android. Android; [cited 10 Spring 2020]. Available: https:\/\/www.android.com\/"},{"key":"pone.0273798.ref052","first-page":"xxii +","volume-title":"Statistics for Biology and Health.","author":"PE Bourdeau","year":"2009"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:51:21Z","timestamp":1675363881000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0273798"}},"subtitle":[],"editor":[{"given":"Luciano Andrade","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0273798","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,2]]}}}