{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:33:59Z","timestamp":1791477239149,"version":"4.3.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the grant from the project for disciplines of excellence, West China Hospital, Sichuan University","award":["ZYJC21056"],"award-info":[{"award-number":["ZYJC21056"]}]},{"name":"the grant from the Science and Technology Department in Sichuan province","award":["2021YJD139"],"award-info":[{"award-number":["2021YJD139"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Tuberculous meningitis (TBM) is one of the most devastating TB. Accurate identification of TBM is helpful to eliminate TB. Therefore, we assessed the performance of TBAg stimulated IFN-\u03b3 (IGRA) and unstimulated IFN-\u03b3 in blood and cerebrospinal fluid (CSF) for diagnosing TBM.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We searched Web of Science, PubMed, Embase and the Cochrane Library databases until March 2022. Bivariate and hierarchical summary receiver operating characteristic models were employed to compute summary estimates for diagnostic accuracy parameters of IGRA and unstimulated IFN-\u03b3 in blood and CSF for diagnosing TBM.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>28 studies including 1,978 participants and 2,641 samples met the inclusion criteria. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and area under the curve (AUROC) of blood IGRA were separately as 0.73, 0.83, 4.32, 0.33, 13.22 and 0.86, indicating a good diagnostic accuracy of blood IGRA for detecting TBM. The summary sensitivity, specificity, PLR, NLR, DOR and AUROC of CSF IGRA were separately as 0.77, 0.91, 8.82, 0.25, 34.59 and 0.93, indicating good diagnostic accuracy of CSF IGRA for detecting TBM. The summary sensitivity, specificity, PLR, NLR, DOR and AUROC of CSF IFN-\u03b3 were separately as 0.86, 0.92, 10.27, 0.16, 65.26 and 0.95, suggesting CSF IFN-\u03b3 provided excellent accuracy for diagnosing TBM.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>For differentiating TBM from non-TBM individuals, blood and CSF IGRA are good assays and unstimulated CSF IFN-\u03b3 is an auxiliary excellent marker.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0273834","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T17:31:59Z","timestamp":1661880719000},"page":"e0273834","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tuberculosis-specific antigen stimulated and unstimulated interferon-\u03b3 for tuberculous meningitis diagnosis: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Fangyu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-2767","authenticated-orcid":true,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"pone.0273834.ref001","volume-title":"Global tuberculosis report 2020","author":"World Health Organization","year":"2020"},{"key":"pone.0273834.ref002","doi-asserted-by":"crossref","first-page":"167","DOI":"10.12688\/wellcomeopenres.15535.1","article-title":"The current global 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