{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:11:07Z","timestamp":1782519067098,"version":"3.54.5"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1116901B"],"award-info":[{"award-number":["TCVGH-1116901B"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Retinitis pigmentosa (RP) is the most frequent retinal hereditary dystrophy and result in blindness if progresses. Several case reports have revealed the possible association between RP and primary angle-closure glaucoma (PACG). We conducted a population-based study to explore whether RP significantly increased the risk of PACG development.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Using the Taiwan National Health Insurance Research Database, we enrolled patients with RP into the RP group from 2001 to 2013 and included a comparison group of 1:4 age- and sex-matched individuals without RP. We performed a Cox regression analysis to estimate the crude and adjusted hazard ratios (HRs) of RP for PACG after adjustment for hypertension, diabetes, hyperlipidaemia, chronic kidney disease, and lens subluxation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>We enrolled 6223 subjects with RP and 24892 subjects for comparison. The mean age of the cohort was 49.0 \u00b1 18.1 years. The RP group had significantly higher percentages of diabetes mellitus, hypertension, and hyperlipidaemia. The cumulative incidence of PACG in patients with RP was 1.61%, which was significantly higher than that in the comparison group (0.81%, p &lt; 0.0001). According to the univariate Cox regression analysis, the hazard of PACG development was significantly greater in the RP group, with an unadjusted HR of 2.09 (95% confidence interval [CI], 1.64\u20132.65). The increased risk persisted after adjusting for confounders (adjusted HR = 2.18; 95% CI, 1.76\u20132.72).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This nationwide population-based cohort study showed that people with RP are at a significantly greater risk of developing PACG than individuals without RP.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0274066","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:53:39Z","timestamp":1662753219000},"page":"e0274066","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between retinitis pigmentosa and an increased risk of primary angle closure glaucoma: A population-based cohort study"],"prefix":"10.1371","volume":"17","author":[{"given":"Man-Chen","family":"Hung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-3819","authenticated-orcid":true,"given":"Yu-Yen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"issue":"6","key":"pone.0274066.ref001","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1755-3768.1993.tb08591.x","article-title":"Primary angle closure glaucoma and retinitis pigmentosa","volume":"71","author":"O Badeeb","year":"1993","journal-title":"Acta Ophthalmol (Copenh)"},{"issue":"1\u20132","key":"pone.0274066.ref002","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000309379","article-title":"Sector retinitis pigmentosa and chronic angle-closure glaucoma: a new association","volume":"189","author":"CA Omphroy","year":"1984","journal-title":"Ophthalmologica"},{"issue":"1\u20132","key":"pone.0274066.ref003","first-page":"17","article-title":"Retinitis pigmentosa associated with glaucoma\u2014clinical analysis","volume":"6","author":"T Peng","year":"1990","journal-title":"Yan Ke Xue Bao"},{"key":"pone.0274066.ref004","first-page":"6023586","article-title":"Angle Closure Glaucoma in Retinitis Pigmentosa","volume":"2020","author":"C Pradhan","year":"2020","journal-title":"Case Rep Ophthalmol Med."},{"key":"pone.0274066.ref005","article-title":"System of Ophthalmology","author":"D. 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