{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:57:59Z","timestamp":1784285879153,"version":"3.55.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20HA2003"],"award-info":[{"award-number":["20HA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) has a high mortality and requires effective treatment with anti-MRSA agents such as vancomycin (VCM). Management of the efficacy and safety of VCM has been implemented with the assignment of pharmacists in hospital wards and the establishment of teams related to infectious diseases. However, there are no reports evaluating the association between these factors and the efficacy and safety of VCM in large populations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study used the Japanese administrative claims database accumulated from 2010 to 2019. The population was divided into two groups, therapeutic drug monitoring (TDM) group and non-TDM group, and adjusted by propensity score matching. We performed multivariate logistic regression analysis to determine the influence of pharmacists and infection control teams or antimicrobial stewardship teams on acute kidney injury (AKI) and 30-day mortality.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The total number of patients was 73 478 (TDM group, n = 55 269; non-TDM group, n = 18 209). After propensity score matching, 18 196 patients were matched in each group. Multivariate logistic regression analysis showed that pharmacological management for each patient contributed to the reduction of AKI (odds ratio [OR]: 0.812, 95% confidence interval [CI]: 0.723\u20120.912) and 30-day mortality (OR: 0.538, 95% CI: 0.503\u20120.575). However, the establishment of infectious disease associated team in facilities and the assignment of pharmacists in the hospital wards had no effect on AKI and 30-day mortality. In addition, TDM did not affect the reduction in AKI (OR: 1.061, 95% CI: 0.948\u20121.187), but reduced 30-day mortality (OR: 0.873, 95% CI: 0.821\u20120.929).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Pharmacologic management for individual patients, rather than assignment systems at facilities, is effective to reduce AKI and 30-day mortality with VCM administration.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0274324","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T20:02:07Z","timestamp":1662753727000},"page":"e0274324","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of pharmacists and infection control teams or antimicrobial stewardship teams on the safety and efficacy of vancomycin: A Japanese administrative claims database study"],"prefix":"10.1371","volume":"17","author":[{"given":"Ryota","family":"Goto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-5676","authenticated-orcid":true,"given":"Yuichi","family":"Muraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Inose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-2338","authenticated-orcid":true,"given":"Yoshiki","family":"Kusama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ishikane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Ohmagari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"pone.0274324.ref001","author":"J. O\u2019Neill","year":"2016","journal-title":"Tackling drug-resistant infections globally: final report and recommendations"},{"key":"pone.0274324.ref002","article-title":"Committee for the preparation of treatment guidelines for MRSA infections","year":"2019","journal-title":"Practical guidelines for the management and treatment of infections caused by MRSA, 2019 Edition [in Japanese]"},{"key":"pone.0274324.ref003","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jiac.2019.10.017","article-title":"National trend of blood-stream infection attributable deaths caused by Staphylococcus aureus and Escherichia coli in Japan","volume":"26","author":"S Tsuzuki","year":"2020","journal-title":"J Infect Chemother"},{"key":"pone.0274324.ref004","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1248\/bpb.b20-00605","article-title":"Trends of the use of anti-methicillin-resistant Staphylococcus aureus agents in Japan based on sales data from 2006 to 2015","volume":"43","author":"R Goto","year":"2020","journal-title":"Biol Pharm Bull"},{"key":"pone.0274324.ref005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijantimicag.2010.10.013","article-title":"Vancomycin-associated nephrotoxicity: A critical appraisal of risk with high-dose therapy","volume":"37","author":"A Wong-Beringer","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"pone.0274324.ref006","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ki.2013.153","article-title":"Raising awareness of acute kidney injury: A global perspective of a silent killer","volume":"84","author":"AJP Lewington","year":"2013","journal-title":"Kidney Int"},{"key":"pone.0274324.ref007","article-title":"Implementing an antibiotic stewardship program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America","author":"TF Barlam","year":"2016","journal-title":"Clin Infect Dis"},{"key":"pone.0274324.ref008","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10156-013-0599-4","article-title":"Practice guidelines for therapeutic drug monitoring of vancomycin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring","volume":"19","author":"K Matsumoto","year":"2013","journal-title":"J Infect Chemother"},{"key":"pone.0274324.ref009","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2147\/IDR.S109485","article-title":"Pharmacist-managed dose adjustment feedback using therapeutic drug monitoring of vancomycin was useful for patients with methicillin-resistant Staphylococcus aureus infections: a single institution experience","volume":"9","author":"R Hirano","year":"2016","journal-title":"Infect Drug Resist"},{"key":"pone.0274324.ref010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12913-020-05288-1","article-title":"Impact of antimicrobial stewardship fee on prescribing for Japanese pediatric patients with upper respiratory infections","volume":"20","author":"Y Muraki","year":"2020","journal-title":"BMC Health Serv Res"},{"key":"pone.0274324.ref011","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s40801-021-00266-3","article-title":"Current status, challenges, and future perspectives of real-world data and real-world evidence in Japan","volume":"8","author":"K Hiramatsu","year":"2021","journal-title":"Drugs Real World Outcomes"},{"key":"pone.0274324.ref012","article-title":"Comparison of patient characteristics and in-hospital mortality between patients with COVID-19 in 2020 and those with influenza in 2017\u20132020: A multicenter, retrospective cohort study in Japan","author":"Y Taniguchi","year":"2022","journal-title":"Lancet Reg Heal\u2014West Pacific"},{"key":"pone.0274324.ref013","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10147-018-1343-y","article-title":"Effect of combination of pre- and postoperative pulmonary rehabilitation on onset of postoperative pneumonia: A retrospective cohort study based on data from the diagnosis procedure combination database in Japan","volume":"24","author":"S Fujimoto","year":"2019","journal-title":"Int J Clin Oncol"},{"key":"pone.0274324.ref014","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40780-020-00174-8","article-title":"Association of the ward pharmacy service with active implementation of therapeutic drug monitoring for vancomycin and teicoplanin-an epidemiological surveillance study using Japanese large health insurance claims database","volume":"6","author":"S Imai","year":"2020","journal-title":"J Pharm Health Care Sci"},{"key":"pone.0274324.ref015","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.jiac.2021.08.012","article-title":"Incidence of acute kidney injury after teicoplanin\u2013or vancomycin\u2013and piperacillin\/tazobactam combination therapy: A comparative study using propensity score matching analysis","volume":"27","author":"K Sazanami","year":"2021","journal-title":"J Infect Chemother"},{"key":"pone.0274324.ref016","doi-asserted-by":"crossref","first-page":"e001821","DOI":"10.1136\/bmjopen-2012-001821","article-title":"Validity of the International Classification of Diseases, Tenth Revision code for acute kidney injury in elderly patients at presentation to the emergency department and at hospital admission","volume":"2","author":"J Hwang","year":"2012","journal-title":"BMJ Open"},{"key":"pone.0274324.ref017","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Y. Kanda","year":"2013","journal-title":"Bone Marrow Transpl"},{"key":"pone.0274324.ref018","article-title":"Impact of pharmacist intervention in reducing vancomycin-associated acute kidney injury: A systematic review and meta-analysis","author":"P Kunming","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"pone.0274324.ref019","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"key":"pone.0274324.ref020","unstructured":"Clinical Practice Guideline for Drug-induced Kidney Injury Advisory Committee. Clinical practice guideline for drug-induced kidney injury in Japan. [Cited 2022 March 15]. Available from: https:\/\/cdn.jsn.or.jp\/academicinfo\/report\/CKD-guideline2016.pdf; 2016; 2016 [in Japanese]."},{"key":"pone.0274324.ref021","doi-asserted-by":"crossref","first-page":"e112008","DOI":"10.1371\/journal.pone.0112008","article-title":"Vancomycin Dosing in Neutropenic Patients","volume":"9","author":"MB Haeseker","year":"2014","journal-title":"PLoS One"},{"key":"pone.0274324.ref022","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jiac.2018.11.001","article-title":"The first nationwide survey of antimicrobial stewardship programs conducted by the Japanese Society of Chemotherapy","volume":"25","author":"M Maeda","year":"2019","journal-title":"J Infect Chemother"},{"key":"pone.0274324.ref023","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/cid\/cit112","article-title":"Early Use of Daptomycin Versus Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia With Vancomycin Minimum Inhibitory Concentration >1 mg\/L: A Matched Cohort Study","volume":"56","author":"KP Murray","year":"2013","journal-title":"Clin Infect Dis"},{"key":"pone.0274324.ref024","author":"Ministry of Health, Labour and Welfare","year":"2019","journal-title":"Annual vital statistics report"},{"key":"pone.0274324.ref025","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: A roadmap for future research","volume":"15","author":"J Cohen","year":"2015","journal-title":"Lancet Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0274324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T20:02:35Z","timestamp":1662753755000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0274324"}},"subtitle":[],"editor":[{"given":"Tze Shien","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0274324","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}