{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:41:18Z","timestamp":1781818878256,"version":"3.54.5"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K23 DA053507"],"award-info":[{"award-number":["K23 DA053507"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002649"],"award-info":[{"award-number":["UL1TR002649"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002648"],"award-info":[{"award-number":["KL2TR002648"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["1R01DA047867"],"award-info":[{"award-number":["1R01DA047867"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["1R01DA047867"],"award-info":[{"award-number":["1R01DA047867"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Amidst the current opioid crisis, there is a need for better integration of substance use disorder screening and treatment across specialties. However, there is no consensus regarding how to best instruct OBGYN trainees in the clinical skills related to opioid and other substance use disorders (SUD). Study objectives were (1) to assess the effectiveness a SUD curriculum to improve self-reported competence among OBGYN residents and (2) to explore its effectiveness to improve attending evaluations of residents\u2019 clinical skills as well as its feasibility and acceptability from the resident perspective.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A pilot 3-session curriculum was developed and adapted to SUD screening and treatment which included readings, didactics, and supervised outpatient clinical experiences for OBGYN post-graduate year 1 (PGY-1) residents rotating through an integrated OBGYN-SUD clinic. Eighteen residents completed pre and post clinical skills self-assessments (SUD screening, counseling, referring, Motivational Interviewing) using an adapted Zwisch Rating Scale (range 1\u20135). Scores were compared between time points using paired t-tests. Sub-samples also (a) were evaluated by the attending on three relevant Accreditation Council for Graduate Medical Education Milestones (ACGME) milestone sets using the web-based feedback program, myTIPreport (n = 10) and (b) completed a qualitative interview (n = 4).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>All PGY-1s (18\/18) across three academic years completed the 3-session SUD curriculum. Clinical skill self-assessments improved significantly in all areas [SUD Screening (2.44 (0.98) vs 3.56 (0.62), p = &lt;0.01); Counseling (1.81 (0.71) vs 3.56 (0.51), p = &lt; .01; Referring (2.03 (0.74) vs 3.17 (0.71), p = &lt; .01; Motivational Interviewing (1.94 (1.06) vs 3.33 (0.69), p = &lt; .01)]. Milestone set levels assigned by attending evaluations (n = 10) also improved. Qualitative data (n = 4) revealed high acceptability; all curriculum components were viewed positively, and feedback was provided (e.g., desire for more patient exposures).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>A pilot SUD curriculum tailored for OBGYN PGY-1 residents that goes beyond opioid prescribing to encompass SUD management is feasible, acceptable and likely effective at improving SUD core clinical skills.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0274563","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T17:40:22Z","timestamp":1663263622000},"page":"e0274563","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Beyond opioid prescribing: Evaluation of a substance use disorder curriculum for OBGYN residents"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-458X","authenticated-orcid":true,"given":"Caitlin E.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhushan","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendr\u00e9e E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnnaMarie","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"pone.0274563.ref001","volume-title":"Drug and Opioid-Involved Overdose Deaths\u2014United States, 2013\u20132017.","author":"L Scholl","year":"2019"},{"key":"pone.0274563.ref002","unstructured":"HHS. Strategy to Combat Opioid Abuse, Misuse, and Overdose: A Framework Based on the Five Point Strategy. In: Services UDoHaH, editor. Washington, D.C.2017."},{"issue":"6","key":"pone.0274563.ref003","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1377\/hlthaff.2016.0098","article-title":"Access To Mental Health Care Increased But Not For Substance Use, While Disparities Remain.","volume":"35","author":"TB Creedon","year":"2016","journal-title":"Health affairs (Project Hope)"},{"issue":"6","key":"pone.0274563.ref004","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1016\/j.jsurg.2019.05.016","article-title":"Residents as Key Effectors of Change in Improving Opioid Prescribing Behavior","volume":"76","author":"E Lancaster","year":"2019","journal-title":"Journal of surgical education"},{"issue":"3","key":"pone.0274563.ref005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/ADM.0000000000000750","article-title":"Evaluation of Resident Physicians\u2019 Knowledge of and Attitudes Towards Prescribing Buprenorphine for Patients With Opioid Use Disorder","volume":"15","author":"B Shuey","year":"2021","journal-title":"Journal of Addiction Medicine"},{"issue":"4","key":"pone.0274563.ref006","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/08897077.2017.1356423","article-title":"Trainees\u2019 knowledge, attitudes, and practices towards caring for the substance-exposed mother-infant dyad","volume":"38","author":"DM Schiff","year":"2017","journal-title":"Substance Abuse"},{"issue":"2","key":"pone.0274563.ref007","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/AOG.0000000000004657","article-title":"What Obstetrician\u2013Gynecologists Should Know About Substance Use Disorders in the Perinatal Period.","volume":"139","author":"MC Smid","year":"2022","journal-title":"Obstetrics & Gynecology."},{"key":"pone.0274563.ref008","unstructured":"ACOG. 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CREOG Educational Objectives, Core Curriculum in Obstetrics and Gynecology, 11th Edition. Washington, DC; 2016."},{"key":"pone.0274563.ref017","volume-title":"HHS Publication No. (SMA) 18\u20135054","author":"SAMHSA","year":"2018"},{"issue":"9","key":"pone.0274563.ref018","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1097\/00001888-199009000-00045","article-title":"The assessment of clinical skills\/competence\/performance.","volume":"65","author":"GE Miller","year":"1990","journal-title":"Academic medicine: journal of the Association of American Medical Colleges"},{"issue":"24","key":"pone.0274563.ref019","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1056\/NEJMoa1005359","article-title":"Neonatal abstinence syndrome after methadone or buprenorphine exposure","volume":"363","author":"HE Jones","year":"2010","journal-title":"The New England journal of medicine"},{"issue":"5","key":"pone.0274563.ref020","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ajog.2016.06.038","article-title":"The role of screening, brief intervention, and 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Johnson","year":"2019","journal-title":"Seminars in perinatology"},{"issue":"5","key":"pone.0274563.ref033","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00001888-199405000-00009","article-title":"Medical education about substance abuse: changes in curriculum and faculty between 1976 and 1992","volume":"69","author":"M Fleming","year":"1994","journal-title":"Academic medicine: journal of the Association of American Medical Colleges"},{"issue":"7","key":"pone.0274563.ref034","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1007\/s11999-015-4173-5","article-title":"Preoperative Opioid Misuse is Associated With Increased Morbidity and Mortality After Elective Orthopaedic Surgery","volume":"473","author":"ME Menendez","year":"2015","journal-title":"Clinical orthopaedics and related research"},{"issue":"6","key":"pone.0274563.ref035","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/SLA.0b013e3182988d59","article-title":"Preoperative alcohol consumption and postoperative complications: a systematic review and meta-analysis","volume":"258","author":"M Eliasen","year":"2013","journal-title":"Annals of surgery"},{"issue":"5","key":"pone.0274563.ref036","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/AOG.0000000000002562","article-title":"Opioid Detoxification During Pregnancy: A Systematic Review.","volume":"131","author":"M Terplan","year":"2018","journal-title":"Obstetrics and gynecology"},{"key":"pone.0274563.ref037","article-title":"An Integrated Care Model for Pregnant and Postpartum Individuals Receiving Medication for Opioid Use Disorder","author":"LP Ellis","year":"2022","journal-title":"Journal of addiction medicine"},{"issue":"5","key":"pone.0274563.ref038","doi-asserted-by":"crossref","first-page":"e182908","DOI":"10.1001\/jamanetworkopen.2018.2908","article-title":"Assessment of Opioid Prescribing Practices Before and After Implementation of a Health System Intervention to Reduce Opioid Overprescribing","volume":"1","author":"BR Meisenberg","year":"2018","journal-title":"JAMA network open"},{"key":"pone.0274563.ref039","first-page":"1","article-title":"Improving Residency Education on Chronic Pain and Opioid Use Disorder: Evaluation of CDC Guideline-Based Education.","author":"A Raheemullah","year":"2019","journal-title":"Substance use & misuse"},{"key":"pone.0274563.ref040","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.15766\/mep_2374-8265.10756","article-title":"Effective Chronic Pain Management and Responsible Opioid Prescribing: Aligning a Resident Workshop to a Protocol for Improved Outcomes.","volume":"14","author":"TE Vettese","year":"2018","journal-title":"MedEdPORTAL: the journal of teaching and learning resources."},{"issue":"2","key":"pone.0274563.ref041","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.amjsurg.2017.11.017","article-title":"Surgical interns: Preparedness for opioid prescribing before and after a training intervention.","volume":"215","author":"MJ Nooromid","year":"2018","journal-title":"American journal of surgery."},{"key":"pone.0274563.ref042","article-title":"Decreasing Postoperative Opioid Prescribing through Education","author":"L Nguyen","year":"2019","journal-title":"Journal of surgical education"},{"issue":"1","key":"pone.0274563.ref043","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsurg.2017.06.020","article-title":"Trainees as Agents of Change in the Opioid Epidemic: Optimizing the Opioid Prescription Practices of Surgical Residents","volume":"75","author":"AS Chiu","year":"2018","journal-title":"Journal of surgical education"},{"issue":"2","key":"pone.0274563.ref044","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.amjsurg.2018.08.007","article-title":"The impact of a curriculum on postoperative opioid prescribing for novice surgical trainees","volume":"217","author":"AS Chiu","year":"2019","journal-title":"American journal of surgery"},{"issue":"4","key":"pone.0274563.ref045","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/08897077.2017.1356423","article-title":"Trainees\u2019 knowledge, attitudes, and practices towards caring for the substance-exposed mother-infant dyad.","volume":"38","author":"DM Schiff","year":"2017","journal-title":"Subst Abus"},{"issue":"3","key":"pone.0274563.ref046","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/08897077.2012.752777","article-title":"A buprenorphine education and training program for primary care residents: implementation and evaluation.","volume":"34","author":"HV Kunins","year":"2013","journal-title":"Subst Abus"},{"issue":"6","key":"pone.0274563.ref047","doi-asserted-by":"crossref","first-page":"339","DOI":"10.12788\/jhm.3544","article-title":"A Resident-Led Intervention to Increase Initiation of Buprenorphine Maintenance for Hospitalized Patients With Opioid Use Disorder","volume":"16","author":"AP Thakrar","year":"2021","journal-title":"Journal of Hospital Medicine"},{"issue":"11","key":"pone.0274563.ref048","doi-asserted-by":"crossref","first-page":"e1002969","DOI":"10.1371\/journal.pmed.1002969","article-title":"Stigma as a fundamental hindrance to the United States opioid overdose crisis response.","volume":"16","author":"AC Tsai","year":"2019","journal-title":"PLoS medicine."},{"key":"pone.0274563.ref049","unstructured":"ASTHO. Stigma Reinforces Barriers to Care for Pregnant and Postpartum Women with Substance Use Disorder: ASSOCIATION OF STATE AND TERRITORIAL HEALTH OFFICIALS; 2019 [Available from: https:\/\/www.astho.org\/ASTHOBriefs\/Stigma-Reinforces-Barriers-to-Care-for-Pregnant-and-Postpartum-Women-with-Substance-Use-Disorder\/."},{"key":"pone.0274563.ref050","unstructured":"NIDA. Words Matter: Terms to Use and Avoid When Talking About Addiction. 2019."},{"key":"pone.0274563.ref051","unstructured":"NIDA. Your Words Matter\u2013Language Showing Compassion and Care for Women, Infants, Families, and Communities Impacted by Substance Use Disorder 2022 [Available from: https:\/\/nida.nih.gov\/nidamed-medical-health-professionals\/health-professions-education\/words-matter-language-showing-compassion-care-women-infants-families-communities-impacted-substance-use-disorder."},{"key":"pone.0274563.ref052","first-page":"107679","article-title":"Unmet substance use disorder treatment need among reproductive age women","author":"CE Martin","year":"2019","journal-title":"Drug and alcohol dependence"},{"key":"pone.0274563.ref053","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jsat.2019.12.005","article-title":"Substance use disorder treatment services for pregnant and postpartum women in residential and outpatient settings","volume":"110","author":"A Meinhofer","year":"2020","journal-title":"Journal of substance abuse treatment"},{"key":"pone.0274563.ref054","unstructured":"Martin CEOpioid Use Disorder in Pregnancy 2020 Available from: [https:\/\/ucsf.app.box.com\/s\/5bfbvl6jr3k33scednri8bqegahyfotg."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0274563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T17:41:34Z","timestamp":1663263694000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0274563"}},"subtitle":[],"editor":[{"given":"Nadine","family":"Harker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0274563","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]}}}