{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:51Z","timestamp":1787022111409,"version":"build-2736575974"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shizuoka prefecture"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40\u2013107 years who were followed prospectively from January 2012 to September 2020 using a dataset composed of two individually linked databases, one containing annual health checkup records and the other containing medical claims for beneficiaries of the National Health Insurance System and the Medical Care System for Elderly in the Latter Stage of Life in Shizuoka Prefecture, Japan. Among the 611,930 participants in the analysis set, 23,843 (3.9%) were diagnosed with gallstones during the observational period (median [max]: 5.68 [7.5] years). Multivariate analysis revealed that risk of gallstone disease was increased by male sex, cerebrovascular disease, any malignancy, dementia, rheumatic disease, chronic pulmonary disease, hypertension, and\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    -infected gastritis. These findings provide essential insights into the etiology of cholelithiasis and may contribute to efforts to reduce the incidence of the disease.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0274659","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T13:58:39Z","timestamp":1672408719000},"page":"e0274659","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort 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Parente","year":"2007","journal-title":"Hepatology"},{"key":"pone.0274659.ref014","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1136\/gut.33.11.1493","article-title":"Colonic preservation reduces need for parenteral therapy, increases incidence of renal stones, but does not change high prevalence of gall stones in patients with a short bowel","volume":"33","author":"JM Nightingale","year":"1992","journal-title":"Gut"},{"key":"pone.0274659.ref015","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2105\/AJPH.83.8.1113","article-title":"Oral contraceptives and the risk of gallbladder disease: a meta-analysis.","volume":"83","author":"C Thijs","year":"1993","journal-title":"Am J Public Health"},{"key":"pone.0274659.ref016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00000658-199201000-00002","article-title":"Gallbladder sludge and stone formation in relation to contractile function after gastrectomy. A prospective study","volume":"215","author":"K Inoue","year":"1992","journal-title":"Ann Surg"},{"key":"pone.0274659.ref017","first-page":"1271","article-title":"Prevalence of cholesterol gallstones positively correlates with per capita daily calorie intake.","volume":"51","author":"K Tsunoda","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"pone.0274659.ref018","article-title":"Data resource profile of Shizuoka Kokuho Database (SKDB) using integrated health- and care-insurance claims and health checkups: the Shizuoka Study.","author":"E Nakatani","year":"2021","journal-title":"J Epidemiol"},{"key":"pone.0274659.ref019","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/s41467-018-07460-y","article-title":"Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.","volume":"9","author":"E Ferkingstad","year":"2018","journal-title":"Nat Commun"},{"key":"pone.0274659.ref020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MOG.0000000000000423","article-title":"An update on the pathogenesis of cholesterol gallstone disease.","volume":"34","author":"A Di Ciaula","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"key":"pone.0274659.ref021","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1001\/jamainternmed.2016.1531","article-title":"Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus.","volume":"176","author":"J-L Faillie","year":"2016","journal-title":"JAMA Intern Med"},{"key":"pone.0274659.ref022","first-page":"3092","article-title":"Association between gallstone and cardio-cerebrovascular disease: Systematic review and meta-analysis.","volume":"17","author":"S-F Zhao","year":"2019","journal-title":"Exp Ther Med"},{"key":"pone.0274659.ref023","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1038\/s41598-019-42327-2","article-title":"Gallstone Disease and the Risk of Cardiovascular Disease.","volume":"9","author":"CJ Fairfield","year":"2019","journal-title":"Sci Rep"},{"key":"pone.0274659.ref024","unstructured":"Ministry of Health, Labour and Welfare, Japan. 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