{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:23:56Z","timestamp":1761402236167,"version":"3.40.5"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Human papilloma virus is associated with oral and oropharyngeal cancer. Our aim was to examine oral health in patients with oropharyngeal (OPSCC) and oral tongue cancer (OTSCC), expecting better oral health among OPSCC patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Material and methods<\/jats:title>\n<jats:p>Fifty-five OPSCC patients with known HPV status and 59 OTSCC patients were randomly selected from a list of consecutive patients of the Helsinki University Hospital, Finland. Oral health was assessed from panoramic jaw radiographs. Total Dental Index (TDI) summarizing the dental health status was calculated and Finnish population study data were used for comparison. Descriptive statistics were used for analyses.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Patients with HPV-positive OPSCC had higher periapical lesion index compared with HPV-negative OPSCC patients or with OTSCC patients. Residual roots were more common among OPSCC patients compared with OTSCC patients, because of their higher occurrence among HPV-negative OPSCC patients compared with OTSCC patients. Similarly, modified TDI score was significantly higher among OPSCC patients than among OTSCC patients, because of higher TDI score among HPV-negative OPSCC patients compared with OTSCC patients. OPSCC patients more often used a removable prosthesis than OTSCC patients. Dental health of the cancer patients was poorer when compared with the population data.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study hypothesis was only partly confirmed. Periapical lesions were more prevalent among HPV-positive OPSCC patients, compared with the other groups. The number of residual roots was higher among HPV-negative subgroup. Thus, OPSCC patients had worse oral health parameters than OTSCC patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0274813","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T18:01:03Z","timestamp":1663869663000},"page":"e0274813","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dental health in patients with and without HPV-positive oropharyngeal and tongue cancer"],"prefix":"10.1371","volume":"17","author":[{"given":"Lauri","family":"Jouhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Siki\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anni","family":"Suomalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayan","family":"Mroueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":true,"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-6836","authenticated-orcid":true,"given":"Jukka H.","family":"Meurman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"pone.0274813.ref001","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"F Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"pone.0274813.ref002","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: A virus-related cancer epidemic","volume":"11","author":"D Marur S","year":"2010","journal-title":"Lancet Oncol"},{"issue":"suppl 1","key":"pone.0274813.ref003","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1007\/s12105-012-0377-0","article-title":"Epidemiology and clinical aspects of HPV in head and neck cancers","volume":"6","author":"AK Chaturvedi","year":"2012","journal-title":"Head Neck Pathol"},{"key":"pone.0274813.ref004","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/00016489.2017.1405279","article-title":"Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients","volume":"138","author":"T Carp\u00e9n","year":"2018","journal-title":"Acta Otolaryngol"},{"key":"pone.0274813.ref005","article-title":"The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil","volume":"15","author":"F Dos Santos Menedes","year":"2020","journal-title":"PLoS ONE"},{"key":"pone.0274813.ref006","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3322\/caac.21293","article-title":"Oral cavity and oropharyngeal squamous cell carcinoma\u2014an update","volume":"65","author":"AC Chi","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"pone.0274813.ref007","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bjoms.2015.08.268","article-title":"Oral precursor lesions and malignant transformation\u2014who, where, what, and when?","volume":"53","author":"ML Goodson","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"pone.0274813.ref008","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1368-8375(00)00076-2","article-title":"Poor dental status increases acetaldehyde production from ethanol in saliva: A possible link to increased oral cancer risk among heavy drinkers","volume":"37","author":"N Homann","year":"2001","journal-title":"Oral Oncol"},{"key":"pone.0274813.ref009","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1080\/00016480510012273","article-title":"Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma. 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