{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:20:08Z","timestamp":1785478808518,"version":"3.56.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Foundation, Ulaanbaatar, Mongolia","award":["Grant No: SHUSs2018\/15"],"award-info":[{"award-number":["Grant No: SHUSs2018\/15"]}]},{"name":"Science and Technology Foundation, Ulaanbaatar, Mongolia"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In Mongolia, gastric cancer morbidity and mortality are high, and more than 80 percent of cases are diagnosed at an advanced stage. This study aimed to evaluate pepsinogens (PGIs) and gastrin-17 (G-17) levels and to determine the diagnostic performances for gastric cancer and chronic atrophic gastritis among Mongolian individuals. We enrolled a total of 120 subjects, including gastric cancer (40), atrophic gastritis (40), and healthy control (40), matched by age (\u00b12) and sex. Pepsinogen I (PGI), Pepsinogen II (PGII), G-17, and <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> IgG levels were measured using GastroPanel ELISA kit (Biohit, Helsinki, Finland). Also, PGI to PGII ratio (PGR) was calculated. For atrophic gastritis, when the optimal cut-off value of PGI was \u226475.07 ng\/ml, the sensitivity and specificity were 75% and 50%, respectively; when the optimal cut-off value of PGR was \u22646.25, sensitivity and specificity were 85% and 44.7%, respectively. For gastric cancer, when the optimal cut-off value of PGI was \u226435.25 ng\/ml, the sensitivity and specificity were 47.2% and 86.8%, respectively; when the optimal cut-off value of PGR was \u22645.27, sensitivity and specificity were 75% and 60.5%, respectively. Combinations of biomarkers with risk factors could improve diagnostic accuracy (AUC for atrophic gastritis 74.8, 95% CI 64.0\u201385.7, p&lt;0.001; AUC for gastric cancer 75.5, 95% CI 64.2\u201386.8, p&lt;0.001). PGI, PGR biomarkers combined with the risk of age, family history of gastric cancer, and previous gastric disease could not be an alternative test for upper endoscopy but might be a supportive method which is identifying individuals at medium- and high risk of gastric cancer and precancerous lesions who may need upper endoscopy.<\/jats:p>","DOI":"10.1371\/journal.pone.0274938","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T17:29:12Z","timestamp":1666027752000},"page":"e0274938","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Diagnostic performances of pepsinogens and gastrin-17 for atrophic gastritis and gastric cancer in Mongolian subjects"],"prefix":"10.1371","volume":"17","author":[{"given":"Ganchimeg","family":"Dondov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashmaa","family":"Amarbayasgalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batbold","family":"Batsaikhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tegshjargal","family":"Badamjav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batchimeg","family":"Batbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baljinnyam","family":"Tuvdenjamts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasanjargal","family":"Tumurbat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayar","family":"Davaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkhembulgan","family":"Purevdorj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayarmaa","family":"Nyamaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-0347","authenticated-orcid":true,"given":"Tulgaa","family":"Lonjid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"issue":"8","key":"pone.0274938.ref001","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11894-017-0575-8","article-title":"Changing Trends in Stomach Cancer Throughout the World","volume":"19","author":"M Balakrishnan","year":"2017","journal-title":"Current gastroenterology reports"},{"issue":"1","key":"pone.0274938.ref002","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5005\/jp-journals-10018-1313","article-title":"Incidence of Stomach and Esophageal Cancers in Mongolia: Data from 2009 to 2018","volume":"10","author":"T Lonjid","year":"2020","journal-title":"Euroasian journal of hepato-gastroenterology"},{"key":"pone.0274938.ref003","unstructured":"WHO. [cited 2020 05.20]. Available from: https:\/\/gco.iarc.fr\/today\/home."},{"issue":"1","key":"pone.0274938.ref004","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s10120-018-0844-8","article-title":"Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area","volume":"22","author":"B Gantuya","year":"2019","journal-title":"Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association"},{"key":"pone.0274938.ref005","first-page":"2019","author":"Center of Health Development MoH, Mongolia","journal-title":"Non-communicable diseases. 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