{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:12:41Z","timestamp":1791537161984,"version":"4.3.4"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Henan Provincial Key Discipline TCM Discipline Construction Project","award":["STG-ZYXKY-202015"],"award-info":[{"award-number":["STG-ZYXKY-202015"]}]},{"name":"the Henan Provincial Administration of Traditional Chinese Medicine project","award":["20-21ZY3009"],"award-info":[{"award-number":["20-21ZY3009"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the effectiveness of the Shengxuexiaoban Capsules combined with glucocorticoid therapy for immune thrombocytopenia (ITP).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We collected randomized controlled trials (RCTs) using shengxuexiaoban capsules in combination with glucocorticoid to treat ITP by searching major Chinese and English electronic databases. The outcome indicators were the effective rate, recurrence rate, the number of platelets in the blood, recovery time of platelets, and adverse reactions. We used STATA 16.0 and RevMan 5.3 for meta-analysis and GRADE pro. for evidence quality evaluation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 27 RCTs were included in the meta-analysis, and the results showed a significant difference (all p&lt;0.05) in the effective rate, recurrence rate, the number of platelets, and the recovery time of platelets (\u2265 100\u00d710<jats:sup>9<\/jats:sup>) between ITP patients in the control group (who received glucocorticoid therapy alone) and test group (who received glucocorticoid therapy combined with the Shengxuexiaoban Capsules). And that Shengxuexiaoban capsules combined with glucocorticoid therapy were safe. The funnel plot and Egger\u2019s test results indicated no obvious publication bias. The GRADE evidence rating showed an intermediate quality of evidence rating for recurrence rate and overall effectiveness.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Glucocorticoid therapy combined with the Shengxuexiaoban Capsules showed more effectiveness in the treatment of ITP. It can improve the effective rate, reduce the recurrence rate, increase the number of platelets and shorten the recovery time of platelets, and has a good safety profile.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0275122","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T17:40:00Z","timestamp":1664559600000},"page":"e0275122","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of shengxuexiaoban capsules combined with glucocorticoid therapy for immune thrombocytopenia: A meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Meng-Yuan","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-975X","authenticated-orcid":true,"given":"Meng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Sheng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Dong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"issue":"11","key":"pone.0275122.ref001","first-page":"58","article-title":"Progress in the Treatment of Primary Immune Thrombocytopenia Based on Qi and Blood [J]","volume":"30","author":"Zhou Lu","year":"2021","journal-title":"Chinese Journal of Ethnomedicine and Ethnopharmacy"},{"issue":"15","key":"pone.0275122.ref002","first-page":"115","article-title":"Clinical Efficacy of Different First-line Treatment Regimens for Primary Immune Thrombocytopenia in Children [J]","volume":"14","author":"Zhang Zhenjian","year":"2021","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"issue":"01","key":"pone.0275122.ref003","first-page":"5","article-title":"Progress in the Diagnosis and Treatment of Primary Immune Thrombocytopenia [J]","volume":"37","author":"Zhang Xiaolin","year":"2020","journal-title":"Journal of Clinical Internal Medicine"},{"issue":"02","key":"pone.0275122.ref004","first-page":"181","article-title":"Progress of Pathogenesis and Treatment of Primary Immune Thrombocytopenia [J]","volume":"23","author":"Pan Xuxu","year":"2020","journal-title":"Practical Pharmacy and Clinical Remedies"},{"issue":"11","key":"pone.0275122.ref005","first-page":"51","article-title":"Clinical Observation on the Treatment of Primary Immune Thrombocytopenia with Shengxuexiaoban Capsules and Glucocorticoid [J]","volume":"26","author":"Li Haiming","year":"2016","journal-title":"Shenzhen Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"04","key":"pone.0275122.ref006","first-page":"273","article-title":"Observation on the Effect of Shengxuexiaoban Capsules in Treating Children\u2019s Idiopathic Thrombocytopenic Purpura [J]","author":"Han Xiaoyue","year":"2008","journal-title":"Central China Medical Journal"},{"key":"pone.0275122.ref007","first-page":"563","article-title":"Clinical Observation of Traditional Chinese Drug Treatment on Idiopathic Thrombocytopenic Purpura in Children [J]","volume":"16","author":"Wang Yi","year":"2006","journal-title":"Chinese Journal of Hemorheology"},{"issue":"2","key":"pone.0275122.ref008","first-page":"422","article-title":"Effect of Sheng Platelet Capsule on CD4^+CD25^+ Treg cells in immune thrombocytopenic purpura [J]","volume":"33","author":"He Muqing","year":"2015","journal-title":"Chinese Journal of Traditional Chinese Medicine"},{"issue":"08","key":"pone.0275122.ref009","first-page":"457","article-title":"Observations of Shengxuexiaoban Capsules Combined with Conventional Therapy on Treatment of Idiopathic Thrombocytopenic Purpura[J]","volume":"24","author":"Yuan Fang","year":"2015","journal-title":"Chinese Journal of Pharmacoepidemiology"},{"issue":"07","key":"pone.0275122.ref010","first-page":"867","article-title":"Clinical Observation of Shengxuexiaoban Capsules Combined with Hormone in Treating Idiopathic Thrombocytopenic Purpura [J]","volume":"18","author":"Du Hui","year":"2014","journal-title":"The Medical Forum"},{"issue":"29","key":"pone.0275122.ref011","first-page":"4067","article-title":"Clinical Observation of Hormone Combined with Shengxuexiaoban Capsules in Treating Idiopathic Thrombocytopenic Purpura [J]","volume":"20","author":"Hu Tianlian","year":"2016","journal-title":"The Medical Forum"},{"issue":"11","key":"pone.0275122.ref012","first-page":"641","article-title":"Curative Effect Observation on Opathic Thrombocytopenic Purpura Treated by Sheng Xuexiaoban Capsules Combined with Prednisone [J]","author":"Wang Wei","year":"2008","journal-title":"Zhejiang Journal of Traditional Chinese Medicine"},{"issue":"05","key":"pone.0275122.ref013","first-page":"116","article-title":"Sheng Platelet Capsule combined with hormone treatment of idiopathic thrombocytopenic purpura curative effect observation [J]","volume":"32","author":"Liang Lijie","year":"2011","journal-title":"Medical Forum Journal"},{"key":"pone.0275122.ref014","first-page":"27","article-title":"Clinical Observation of Maintenance Therapy by Shen Xue-xiao-ban Capsules Combined with Low-dose Prednisone in Chronic ITP Patients [J]","author":"Xu Ling","year":"2014","journal-title":"Chinese Journal of Trauma and Disability Medicine"},{"issue":"04","key":"pone.0275122.ref015","first-page":"440","article-title":"Observation on the Therapeutic Effect of Shengxuexiaoban Capsules Combined with Prednisone in the Treatment of Adult Chronic Idiopathic Thrombocytopenic Purpura [J]","volume":"31","author":"Wang Jiru","year":"2012","journal-title":"Herald of Medicine"},{"issue":"30","key":"pone.0275122.ref016","first-page":"4218","article-title":"Observation on the Therapeutic Effect of Shengxuexiaoban Capsules and Prednisone in the Treatment of Idiopathic Thrombocytopenic Purpura [J]","volume":"19","author":"Zhang Xiaowen","year":"2015","journal-title":"The Medical Forum"},{"issue":"20","key":"pone.0275122.ref017","first-page":"106","article-title":"Study on the Effect of Shengxuexiaoban Capsules Combined with Prednisone in the Treatment of Chronic Immune Thrombocytopenic Purpura [J]","volume":"17","author":"Chen Jianlan","year":"2019","journal-title":"Contemporary Medical Symposium"},{"key":"pone.0275122.ref018","first-page":"192","article-title":"Observation on the Effect of Shengxuexiaoban Capsules on Idiopathic Thrombocytopenic Purpura [J]","author":"Li Wenlei","year":"2018","journal-title":"Health Must-Read Magazine"},{"issue":"05","key":"pone.0275122.ref019","first-page":"1205","article-title":"Clinical Observation of Ascending Platelets Capsule Combined with Prednisone in Treatment of Primary Immune Thrombocytopenia and Its Effect on Treg and Th17 Cells [J]","volume":"37","author":"Cai Gangli","year":"2019","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"pone.0275122.ref020","first-page":"1319","article-title":"Clinical Observation on the Clinical Effect of Shengxuexiaoban Capsules Combined with Prednisone Acetate in the Treatment of Primary Immune Thrombocytopenia [J]","volume":"19","author":"Yu Bin","year":"2019","journal-title":"Chinese Remedies & Clinics"},{"issue":"23","key":"pone.0275122.ref021","first-page":"42","article-title":"Study on the effect of Shengban Capsule combined with prednisone in the treatment of chronic immune thrombocytopenic purpura [J]","author":"Jiang Ming","year":"2021","journal-title":"Health Vision"},{"key":"pone.0275122.ref022","first-page":"360","article-title":"Effect of L Platelet Capsule Combined with Prednison on Treg Cells and Th17 Cells of Primary Immune Thrombocytopenia [J]","author":"Xiang Qi","year":"2015","journal-title":"Chinese Journal of Thrombosis and Hemostasis"},{"issue":"02","key":"pone.0275122.ref023","first-page":"75","article-title":"Observation on the Treatment of 62 Patients with Chronic ITP by Shengxuexiaoban Capsules Combined with Prednisone [J]","volume":"47","author":"Wang Wei","year":"2009","journal-title":"China Modern Doctor"},{"issue":"26","key":"pone.0275122.ref024","first-page":"96","article-title":"Observation on the Efficacy of Shengxuexiaoban Capsules Combined with Prednisone in the Treatment of 20 Patients with Idiopathic Thrombocytopenic Purpura [J]","volume":"7","author":"Sun Shaoyuan","year":"2014","journal-title":"Chinese Journal of Clinical Rational Drug Use"},{"issue":"10","key":"pone.0275122.ref025","first-page":"23","article-title":"Observation of Therapeutic Effect of Shengxuexiaoban Capsules Combined with Glucocorticoid on Idiopathic Thrombocytopenic Purpura [J]","volume":"9","author":"Chen Jiawei","year":"2012","journal-title":"Journal of North Pharmacy"},{"issue":"14","key":"pone.0275122.ref026","first-page":"1683","article-title":"Clinical Observation on Treatment of Adult Primary Immune Thrombocytopenia with Shengxuexiaoban Capsules and Low-dose Hormone [J]","volume":"45","author":"Yang Jixiang","year":"2016","journal-title":"Shanxi Medical Journal"},{"issue":"77","key":"pone.0275122.ref027","first-page":"79","article-title":"Clinical Observation on the Treatment of 32 Patients of Idiopathic Thrombocytopenic Purpura with Shengxuexiaoban Capsules and Hormone [J]","volume":"24","author":"Zhang Weidong","year":"2011","journal-title":"Medical Information"},{"issue":"19","key":"pone.0275122.ref028","first-page":"54","article-title":"Clinical Observation on the Treatment of 40 Patients of Idiopathic Thrombocytopenic Purpura with Shengxuexiaoban Capsules and Hormone [J]","author":"Liang Jinqiu","year":"2007","journal-title":"China Medical Herald"},{"issue":"10","key":"pone.0275122.ref029","first-page":"917","article-title":"Observastion of the Efficacy of Sheng Xuexiaoban Capsules Combined with Prednisone on the Treatment of Ldiopathic Thrombocytopenic Purpura [J]","volume":"16","author":"Song Chunge","year":"2010","journal-title":"Chinese Journal of Basic Medicine in Traditional Chinese Medicine"},{"issue":"04","key":"pone.0275122.ref030","first-page":"233","article-title":"Observation of the Efficacy of Sheng Xuexiaoban Capsules on the Treatment of Idiopathic Thrombocytopenic Purpura (ITP) [J]","author":"Liu Ling","year":"2004","journal-title":"Evaluation and Analysis of Drug-Use in Hospitals of China"},{"issue":"7","key":"pone.0275122.ref031","first-page":"97","article-title":"Observation on curative effect of Sheng Platelet Capsule combined with prednisone in the treatment of idiopathic thrombocytopenic purpura [J]","volume":"5","author":"Ma Liangming","year":"2004","journal-title":"Chinese Journal of Clinical Medicine"},{"issue":"6","key":"pone.0275122.ref032","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/MOH.0000000000000612","article-title":"An update on the pathophysiology of immune thrombocytopenia","volume":"27","author":"JW Semple","year":"2020","journal-title":"Curr Opin Hematol"},{"issue":"12","key":"pone.0275122.ref033","first-page":"3330","article-title":"Study on the Material Basis and Mechanism of Shengxuexiaoban Capsules Based on Network Pharmacology [J]","volume":"42","author":"Li Linfeng","year":"2020","journal-title":"Chinese Traditional Patent Medicine"},{"issue":"09","key":"pone.0275122.ref034","first-page":"4536","article-title":"Guidelines for diagnosis and treatment of Chinese medicine evidence of different stages of hormone use [J]","volume":"35","author":"Wen Chengping","year":"2020","journal-title":"Chinese Journal of Traditional Chinese Medicine"},{"issue":"07","key":"pone.0275122.ref035","first-page":"852","article-title":"Effectiveness of Shengxuexiaoban Capsules Combined with Hormone in Treating Idiopathic Thrombocytopenic Purpura: A Systematic Review [J]","volume":"13","author":"Ye Huami","year":"2013","journal-title":"Chinese Journal of Evidence-Based Medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0275122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T17:40:47Z","timestamp":1664559647000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0275122"}},"subtitle":[],"editor":[{"given":"Mohamed A","family":"Yassin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0275122","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}