{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:04:34Z","timestamp":1787846674135,"version":"build-2784847793"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2167"],"award-info":[{"award-number":["EXC2167"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2167"],"award-info":[{"award-number":["EXC2167"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Psoriasis is a chronic immune-mediated inflammatory disease. Beyond the physical dimensions, the disease has an extensive emotional and psychosocial effect on patients, influencing their quality of life, social life and interpersonal relationships. Thus patient-reported outcomes are a crucial instrument for the evaluation of disease burden. Navigating life in times of the COVID-19 pandemic is challenging, especially for persons suffering from chronic diseases. We here analyzed the impact of lockdown restrictions on psoriasis patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To compare the Dermatology Life Quality Index (DLQI) before and during the COVID-19 pandemic of patients with psoriasis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective longitudinal analysis in adult patients with moderate to severe psoriasis undergoing biologic treatment between January 2020 and January 2021. DLQI, patient demographics, Psoriasis Area and Severity Index (PASI), and recent biologic treatment were recorded.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>103 patients were identified, of whom 19 had additional psoriatic arthritis. Female (n = 29) and male (n = 74) patients were distributed 1 to 3. Median age of patients was 54 years (range 18\u201385). All patients received biologic systemic treatment: anti-IL-23 (n = 39), anti-IL-17A (n = 30), anti-IL-12\/23 (n = 25), or anti-TNF\u03b1 (n = 9). Comparing DLQI scores before the COVID-19 pandemic and under lockdown restriction showed improved DLQI scores over time. Further analysis displayed that patients mostly ticked \u201cnot relevant\u201d on social activities during lockdown. Thus, the DLQI scores may be artificial improved and may not really reflect the actual disease burden.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Psoriasis patients showed a contrary improvement of life quality despite harsh COVID-19 lockdown suggesting that DLQI should be modified when social life is restricted.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0275293","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T17:32:44Z","timestamp":1664299964000},"page":"e0275293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Paradoxical improvement of life quality in the COVID-19 era in psoriasis patients"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-4886","authenticated-orcid":true,"given":"Katharina","family":"Boch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamant","family":"Tha\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"issue":"10281","key":"pone.0275293.ref001","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"CEM Griffiths","year":"2021","journal-title":"Lancet"},{"issue":"9583","key":"pone.0275293.ref002","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"CE Griffiths","year":"2007","journal-title":"Lancet"},{"issue":"10136","key":"pone.0275293.ref003","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"DJ Veale","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"pone.0275293.ref004","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jdv.12106","article-title":"Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies","volume":"28","author":"PL Mattei","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"pone.0275293.ref005","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000250839","article-title":"Severe psoriasis\u2013oral therapy with a new retinoid","volume":"157","author":"T Frediksson","year":"1978","journal-title":"Dermatologica"},{"key":"pone.0275293.ref006","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology Life Quality Index (DLQI): a simple practical measure for routine clinical use","volume":"19","author":"AY Finlay","year":"1994","journal-title":"Clin Exp Dermatol"},{"issue":"4","key":"pone.0275293.ref007","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jaad.2018.11.057","article-title":"Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics","volume":"80","author":"A Menter","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"pone.0275293.ref008","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1007\/s10198-014-0600-x","article-title":"Exploring the relationship between EQ-5D, DLQI and PASI, and mapping EQ-5D utilities: a cross-sectional study in psoriasis from Hungary","volume":"1","author":"E Her\u00e9di","year":"2014","journal-title":"Eur J Health Econ"},{"issue":"1","key":"pone.0275293.ref009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/bjd.20705","article-title":"\u2019Not relevant\u2019 responses in the era of COVID-19: are we underestimating Dermatology Life Quality Index values?","volume":"186","author":"N Kearney","year":"2022","journal-title":"Br J Dermatol"},{"issue":"5","key":"pone.0275293.ref010","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/jdv.14676","article-title":"A detailed analysis of \u2019not relevant\u2019 responses on the DLQI in psoriasis: potential biases in treatment decisions","volume":"32","author":"F Rencz","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5","key":"pone.0275293.ref011","first-page":"997","article-title":"The Dermatology Life Quality Index 1994\u20132007: a comprehensive review of validation data and clinical results","volume":"159","author":"MK Basra","year":"2008","journal-title":"Br J Dermatol"},{"issue":"4","key":"pone.0275293.ref012","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.0022-202X.2005.23621.x","article-title":"Translating the science of quality of life into practice: What do dermatology life quality index scores mean?","volume":"125","author":"Y Hongbo","year":"2005","journal-title":"J Invest Dermatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0275293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T17:32:55Z","timestamp":1664299975000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0275293"}},"subtitle":[],"editor":[{"given":"Mohd","family":"Adnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0275293","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]}}}