{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:37:24Z","timestamp":1773700644523,"version":"3.50.1"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>In early terminations of pregnancy for fetal anomaly (TOPFA) without identified cytogenetic abnormality, a fetal autopsy is recommended for diagnostic purposes, to guide genetic counseling. Medical induction, which allows analysis of a complete fetus, is generally preferred over surgical vacuum aspiration. Our objective was to assess the diagnostic value of fetal autopsies in these early terminations, relative to the first-trimester ultrasound, overall and by termination method.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Materials<\/jats:title><jats:p>For this retrospective study at the Port Royal Maternity Hospital, we identified all TOPFA performed from 11 weeks to 16 weeks diagnosed at the first-trimester ultrasound in cases with a normal karyotype. The principal endpoint was the additional value of the autopsy over \/compared to the ultrasound and its impact on genetic counseling, globally and by termination method. The secondary objective was to compare the complication rate by method of termination.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The study included 79 women during period of 2013\u20132017: 42 with terminations by medical induction and 37 by aspiration. Fetal autopsy found additional abnormalities in 54.4% of cases, more frequently after medical induction (77.5%) than after aspiration (21.4%, p &lt; .01). Genetic counseling was modified in 20.6% of cases, more often after induction (32.5% vs 3.6%, p &lt; .01). The length of stay was significantly longer and a secondary aspiration was required in 16,7% of case in the medical induction group (p &lt; .01).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>Medically induced vaginal expulsion appears preferable and can change genetic counseling for subsequent pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0275674","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:40:57Z","timestamp":1666201257000},"page":"e0275674","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic value of fetal autopsy after early termination of pregnancy for fetal 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autopsy findings in fetal anomalies terminated in the second trimester","volume":"27","author":"H Akgun","year":"2007","journal-title":"Prenat Diagn"},{"issue":"3","key":"pone.0275674.ref005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0412.2011.01329.x","article-title":"Correlation between prenatal diagnosis by ultrasound and fetal autopsy findings in second-trimester abortions","volume":"91","author":"L Hauerberg","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"pone.0275674.ref006","first-page":"169","article-title":"Does autopsy of antenatally diagnosed malformed foetuses aid genetic counselling?","volume":"11","author":"J Pahi","journal-title":"Natl Med J India"},{"issue":"5","key":"pone.0275674.ref007","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/jcu.20688","article-title":"Comparison of prenatal ultrasound findings and autopsy findings in fetuses terminated after prenatal diagnosis of malformations: an 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Piercecchi-Marti","year":"2004","journal-title":"Forensic Sci Int"},{"key":"pone.0275674.ref011","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejogrb.2016.12.024","article-title":"Correlation between fetal autopsy and prenatal diagnosis by ultrasound: A systematic review","volume":"210","author":"AC Rossi","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"pone.0275674.ref012","doi-asserted-by":"crossref","first-page":"467.e1","DOI":"10.1016\/j.ajog.2011.06.066","article-title":"Fetopathologic examination for early termination of pregnancy: dogma or necessity?","volume":"205","author":"L Gitz","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"pone.0275674.ref013","first-page":"CD006714","article-title":"Surgical versus medical methods for second trimester induced abortion","volume":"23","author":"PA Lohr","year":"2008","journal-title":"Cochrane database Syst 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