{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:34Z","timestamp":1789570954579,"version":"build-2803163510"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination of Superior Level Staff Improvement-Brazil","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}]},{"DOI":"10.13039\/501100006181","name":"Research Support Foundation of the State of Bahia","doi-asserted-by":"crossref","award":["BOL0261\/2018"],"award-info":[{"award-number":["BOL0261\/2018"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006181","name":"Research Support Foundation of the State of Bahia","doi-asserted-by":"crossref","award":["BOL0932\/20"],"award-info":[{"award-number":["BOL0932\/20"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["306222\/2013-2"],"award-info":[{"award-number":["306222\/2013-2"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["304811\/2017-3"],"award-info":[{"award-number":["304811\/2017-3"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["309263\/2020-4"],"award-info":[{"award-number":["309263\/2020-4"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In Brazil, the notification of congenital (CS) and syphilis in pregnant women (SiP) is compulsory. Notification data provided by the Ministry of Health in combination with the mapping of vulnerable geographic areas is essential to forecasting possible outbreaks and more effectively combating infection through monitoring. We aim to evaluate the spatiotemporal distribution and epidemiological aspects of reported cases of CS and SiP in Brazil. A retrospective ecological study was carried out using secondary surveillance data obtained from the Brazilian National Notifiable Diseases Information System (SINAN) database, considering all reported cases of CS and SiP between 2001 to 2017. Epidemiological characteristics and time trends were analyzed using joinpoint regression models and spatial distribution, considering microregions or states\/macroregions as units of analysis. A total of 188,630 (359\/100,000 birth lives) CS and 235,895 of SiP (6.3\/100,000 inhabitants) were reported during the period studied. In general, the epidemiologic profile of Brazil indicates most reported CS cases occurred in \"mixed-race\" newborns who were diagnosed within seven days of birth and whose mothers had received prenatal care, but the epidemiologic profile varies by Brazilian macroregion. Regarding SiP, most cases were among women who self-reported \u2018mixed-race\u2019, were aged 20\u201339 years, had up to eight years of formal education and were diagnosed with primary or latent syphilis. Approximately 549 (98.4%) and 558 (100%) microregions reported at least one case of CS and SiP, respectively. From 2012 to 2016, CS cases increased significantly in almost all Brazilian states, most notably in the South, Southeast, and Central-West macroregions, from 2001\u20132017 and the relative risk (RR) of SiP increased around 400% (RR: 1,00 to 445,50). Considering the epidemiological scenario of the infection in Brazil, it is necessary to enhance preventive, control and eradication measures.<\/jats:p>","DOI":"10.1371\/journal.pone.0275731","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T17:38:50Z","timestamp":1665077930000},"page":"e0275731","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Spatiotemporal distribution analysis of syphilis in Brazil: Cases of congenital and syphilis in pregnant women from 2001\u20132017"],"prefix":"10.1371","volume":"17","author":[{"given":"\u00c2ngelo Ant\u00f4nio Oliveira","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Maia","family":"Leony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayner Vieira de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Erdens Maron","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona Tavares","family":"Daltro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Ferreira","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa de Carvalho Medrado","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda Rios","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Gustavo","family":"Regis-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-0818","authenticated-orcid":true,"given":"Fred Luciano Neves","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"pone.0275731.ref001","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.00070-13","article-title":"The endemic treponematoses","author":"L Giacani","year":"2014","journal-title":"Clinical Microbiology Reviews"},{"key":"pone.0275731.ref002","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016","volume":"97","author":"J Rowley","year":"2019","journal-title":"Bull World Health Organ"},{"key":"pone.0275731.ref003","first-page":"1","article-title":"Global burden of maternal and congenital syphilis and associated adverse birth outcomes\u2014Estimates for 2016 and progress since 2012","author":"EL Korenromp","year":"2019","journal-title":"PLoS ONE. 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