{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:51:02Z","timestamp":1793303462001,"version":"4.5.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["25609819"],"award-info":[{"award-number":["25609819"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["G-YBZN"],"award-info":[{"award-number":["G-YBZN"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>The current study investigated the therapeutic potential of transcranial direct current stimulation (tDCS) on speech intelligibility, speech-related physiological and vocal functions among post-stroke dysarthric patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>Nine chronic post-stroke dysarthric patients were randomly assigned to the stimulation or sham group. The stimulation group received 2mA of anodal tDCS over the left inferior primary motor cortex for 15 minutes, while the sham group received 30s of stimulation under the same settings. All the participants received 10 daily 15 minutes of individualized speech therapy targeting their dominant phonological process or phonemes with the greatest difficulty. The outcome measures included (1) perceptual analysis of single words, passage reading and diadochokinetic rate, (2) acoustic analysis of a sustained vowel, and (3) kinematic analysis of rapid syllable repetitions and syllable production in sentence, conducted before and after the treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The results revealed that both the stimulation and sham groups had improved perceptual speech intelligibility at the word level, reduced short rushes of speech during passage reading, improved rate during alternating motion rate, AMR-k<jats:sup>h<\/jats:sup>a1, and improved articulatory kinematics in AMR-t<jats:sup>h<\/jats:sup>a1 and syllables \/t<jats:sup>h<\/jats:sup>a1\/ and \/k<jats:sup>h<\/jats:sup>a1\/ production in sentence. Compared to the sham group, the stimulation group showed significant improvement in articulatory kinematics in AMR-k<jats:sup>h<\/jats:sup>a1 and syllable \/k<jats:sup>h<\/jats:sup>a1\/ production in sentence. The findings also showed that anodal stimulation led to reduced shimmer value in sustained vowel \/a\/ phonation, positive changes in articulatory kinematics in AMR-t<jats:sup>h<\/jats:sup>a1 and syllables \/p<jats:sup>h<\/jats:sup>a1\/ and \/k<jats:sup>h<\/jats:sup>a1\/ production in sentence at the post treatment measure. In addition to positive effects on articulatory control, reduced perturbation of voice amplitude documented in the stimulation group post treatment suggests possible tDCS effects on the vocal function.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The current study documented the beneficial effects of anodal tDCS over the primary motor cortex on speech production and suggested that combined tDCS and speech therapy may promote recovery from post-stroke dysarthria.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0275779","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T17:30:47Z","timestamp":1665682247000},"page":"e0275779","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transcranial direct current stimulation over the primary motor cortex improves speech production in post-stroke dysarthric speakers: A randomized pilot study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-3566","authenticated-orcid":true,"given":"Min Ney","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-4083","authenticated-orcid":true,"given":"Faisal Nouman","family":"Baig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeuk Ki","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manwa L.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Shiu Kwong","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"issue":"6","key":"pone.0275779.ref001","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1161\/01.STR.32.6.1279","article-title":"Estimates of the prevalence of acute stroke impairments and disability in a multiethnic population","volume":"32","author":"ES Lawrence","year":"2001","journal-title":"Stroke"},{"issue":"6","key":"pone.0275779.ref002","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1310\/tsr1606-463","article-title":"Evidence-based review of stroke rehabilitation: Executive summary. 12th ed","volume":"16","author":"R Teasell","year":"2009","journal-title":"Top Stroke Rehabil"},{"key":"pone.0275779.ref003","volume-title":"Motor speech disorders: Substrates, differential diagnosis, and management","author":"JR Duffy","year":"2019"},{"issue":"10\/11","key":"pone.0275779.ref004","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/02687040143000276","article-title":"Defining aphasia: Some theoretical and clinical implications of operating from a formal definition","volume":"15","author":"MR McNeil","year":"2001","journal-title":"Aphasiology"},{"issue":"01","key":"pone.0275779.ref005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0037-1608852","article-title":"Dysarthria following stroke","volume":"39","author":"KA Spencer","year":"2018","journal-title":"Semin. 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