{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:35:35Z","timestamp":1793144135996,"version":"4.5.0"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing municipal Health Commission Program","award":["2020GDRC002"],"award-info":[{"award-number":["2020GDRC002"]}],"id":[{"id":"https:\/\/ror.org\/04ce5fg13","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Program for Western Dental Clinical Research Fund of Chinese Stomatological Association","award":["CSA-W2020-04"],"award-info":[{"award-number":["CSA-W2020-04"]}],"id":[{"id":"https:\/\/ror.org\/0331ehw12","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Youth Innovation in Future Medicine of Chongqing Medical University","award":["W0055"],"award-info":[{"award-number":["W0055"]}],"id":[{"id":"https:\/\/ror.org\/017z00e58","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association of head and cervical posture with malocclusion has been studied for many years. Despite extensively encouraging researches, no conclusive evidence has been reached for clinical application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the question \u201cDoes head and cervical posture correlate to malocclusion?\u201d, a systematic review and meta-analysis based on the available studies were carried out (PROSPERO registration number: CRD42022319742).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A search of PubMed, Embase, Cochrane Library, and the grey literature was performed without language restrictions. The study screening, data extraction, risk-of-bias evaluation and methodological quality assessment were performed by two independent investigators. When a disagreement arose, a third author was consulted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>6 original cross-sectional studies involving 505 participants were included, which were of moderate methodological quality. NL\/VER in Class \u2161 group and NL\/CVT in Class \u2162 group showed significant differences compared to Class \u2160 group, but no significant differences were observed in most of the variables like NSL\/VER, OPT\/CVT, OPT\/HOR, CVT\/HOR, NSL\/OPT, NSL\/CVT, NL\/OPT in Class \u2161 and \u2162 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggested that the current research evidence is not sound enough to prove the association of head and cervical posture with sagittal malocclusion. Better controlled design and a larger sample size are required for clarifying this question in future study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0276156","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T13:29:50Z","timestamp":1666704590000},"page":"e0276156","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Does head and cervical posture correlate to malocclusion? 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Solow","year":"1976","journal-title":"Am J Phys Anthropol"},{"issue":"2","key":"pone.0276156.ref035","first-page":"97","article-title":"Evidence-based healthcare in developing countries","volume":"8","author":"A Pearson","year":"2010","journal-title":"Int J Evid Based Healthc"},{"issue":"11","key":"pone.0276156.ref036","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JP Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"7414","key":"pone.0276156.ref037","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"BMJ"},{"issue":"1","key":"pone.0276156.ref038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4034\/PBOCI.2017.171.07","article-title":"Craniocervical posture in children with class I, II and III 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