{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:01:49Z","timestamp":1785207709305,"version":"3.55.0"},"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1 R21 AA026711"],"award-info":[{"award-number":["1 R21 AA026711"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1 R21 AA026711"],"award-info":[{"award-number":["1 R21 AA026711"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>E26 transformation specific (ETS) family transcription factors are expressed during embryogenesis and are involved in various cellular processes such as proliferation, migration, differentiation, angiogenesis, apoptosis, and survival of cellular lineages to ensure appropriate development. Dysregulated expression of many of the ETS family members is detected in different cancers. The human ELF3, a member of the ETS family of transcription factors, plays a role in the induction and progression of human cancers is well studied. However, little is known about the role of ELF3 in early development. Here, the zebrafish <jats:italic>elf3<\/jats:italic> was cloned, and its expression was analyzed during zebrafish development. Zebrafish <jats:italic>elf3<\/jats:italic> is maternally deposited. At different developmental stages, <jats:italic>elf3<\/jats:italic> expression was detected in different tissue, mainly neural tissues, endoderm-derived tissues, cartilage, heart, pronephric duct, blood vessels, and notochord. The expression levels were high at the tissue boundaries. Elf3 loss-of-function consequences were examined by using translation blocking antisense morpholino oligonucleotides, and effects were validated using CRISPR\/Cas9 knockdown. Elf3-knockdown produced short and bent larvae with notochord, craniofacial cartilage, and fin defects. The extracellular matrix (ECM) in the fin and notochord was disorganized. Neural defects were also observed. Optic nerve fasciculation (bundling) and arborization in the optic tectum were defective in Elf3-morphants, and fragmentation of spinal motor neurons were evident. Dysregulation of genes encoding ECM proteins and matrix metalloprotease (MMP) and disorganization of ECM may play a role in the observed defects in Elf3 morphants. We conclude that zebrafish Elf3 is required for epidermal, mesenchymal, and neural tissue development.<\/jats:p>","DOI":"10.1371\/journal.pone.0276255","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T18:33:26Z","timestamp":1668623606000},"page":"e0276255","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis"],"prefix":"10.1371","volume":"17","author":[{"given":"Swapnalee","family":"Sarmah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-2308","authenticated-orcid":true,"given":"Priyadharshini","family":"Manikandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-7126","authenticated-orcid":true,"given":"James A.","family":"Marrs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"pone.0276255.ref001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1119(02)01156-3","article-title":"Molecular biology of the Ets family of transcription factors","volume":"303","author":"T Oikawa","year":"2003","journal-title":"Gene"},{"issue":"1\u20132","key":"pone.0276255.ref002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1432-1033.1993.tb19864.x","article-title":"The Ets family of transcription factors","volume":"211","author":"B Wasylyk","year":"1993","journal-title":"Eur J Biochem"},{"issue":"11","key":"pone.0276255.ref003","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1182\/blood.V95.11.3341.011k44_3341_3348","article-title":"Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1\/ETV6","volume":"95","author":"MD Potter","year":"2000","journal-title":"Blood"},{"issue":"4","key":"pone.0276255.ref004","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jmb.2004.07.094","article-title":"Diversity in structure and function of the Ets family PNT domains","volume":"342","author":"CD Mackereth","year":"2004","journal-title":"J Mol Biol"},{"issue":"8","key":"pone.0276255.ref005","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1128\/MCB.17.8.4419","article-title":"Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family","volume":"17","author":"P Oettgen","year":"1997","journal-title":"Mol Cell Biol"},{"issue":"19","key":"pone.0276255.ref006","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1093\/nar\/26.19.4413","article-title":"AT-hook motifs identified in a wide variety of DNA-binding proteins","volume":"26","author":"L Aravind","year":"1998","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pone.0276255.ref007","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1074\/jbc.M609907200","article-title":"Different domains of the transcription factor ELF3 are required in a promoter-specific manner and multiple domains control its binding to DNA","volume":"282","author":"JL Kopp","year":"2007","journal-title":"J Biol Chem"},{"issue":"55","key":"pone.0276255.ref008","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1038\/sj.onc.1204044","article-title":"The Ets-transcription factor family in embryonic development: lessons from the amphibian and bird","volume":"19","author":"P Remy","year":"2000","journal-title":"Oncogene"},{"issue":"2","key":"pone.0276255.ref009","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bbrc.2006.03.192","article-title":"The role of ETS transcription factors in transcription and development of mouse preimplantation embryos","volume":"344","author":"S Kageyama","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"pone.0276255.ref010","first-page":"1417","article-title":"Ets transcription factors in intestinal morphogenesis, homeostasis and disease","volume":"23","author":"P Jedlicka","year":"2008","journal-title":"Histol Histopathol"},{"issue":"4","key":"pone.0276255.ref011","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1053\/j.gastro.2007.02.054","article-title":"TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice","volume":"132","author":"N Flentjar","year":"2007","journal-title":"Gastroenterology"},{"key":"pone.0276255.ref012","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biocel.2017.12.002","article-title":"Overexpression of ELF3 facilitates cell growth and metastasis through PI3K\/Akt and ERK signaling pathways in non-small cell lung cancer","volume":"94","author":"H Wang","year":"2018","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"pone.0276255.ref013","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/104454903321515896","article-title":"The epithelial-specific ETS transcription factor ESX\/ESE-1\/Elf-3 modulates breast cancer-associated gene expression","volume":"22","author":"KL Eckel","year":"2003","journal-title":"DNA Cell Biol"},{"issue":"1","key":"pone.0276255.ref014","first-page":"570","article-title":"E26 transformation (ETS)\u2011specific related transcription factor\u20113 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK\/Erk pathway to drive thyroid cancer.","volume":"41","author":"H Chen","year":"2019","journal-title":"Oncol Rep"},{"issue":"1","key":"pone.0276255.ref015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.21873\/invivo.12248","article-title":"ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer","volume":"35","author":"A Takaoka","year":"2021","journal-title":"In Vivo"},{"issue":"4","key":"pone.0276255.ref016","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.celrep.2015.12.005","article-title":"Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.","volume":"14","author":"MC Gingras","year":"2016","journal-title":"Cell Rep"},{"issue":"2","key":"pone.0276255.ref017","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ccell.2015.12.012","article-title":"Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma","volume":"29","author":"S Yachida","year":"2016","journal-title":"Cancer Cell"},{"issue":"10","key":"pone.0276255.ref018","doi-asserted-by":"crossref","first-page":"16951","DOI":"10.18632\/oncotarget.15208","article-title":"ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells","volume":"8","author":"TL Yeung","year":"2017","journal-title":"Oncotarget"},{"key":"pone.0276255.ref019","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.2147\/IJGM.S332320","article-title":"The Immune-Related Gene ELF3 is a Novel Biomarker for the Prognosis of Ovarian Cancer","volume":"14","author":"H Xu","year":"2021","journal-title":"Int J Gen Med"},{"issue":"4","key":"pone.0276255.ref020","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s11033-022-07145-2","article-title":"Identification of the gene expression changes and gene regulatory aspects in ELF3 mutant bladder cancer","volume":"49","author":"PY Guneri-Sozeri","year":"2022","journal-title":"Mol Biol Rep"},{"issue":"50","key":"pone.0276255.ref021","doi-asserted-by":"crossref","first-page":"38941","DOI":"10.1074\/jbc.M608389200","article-title":"Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3","volume":"281","author":"Y Kohno","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"pone.0276255.ref022","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/toxsci\/kfm192","article-title":"Matrix metalloproteinase-13 is required for zebra fish (Danio rerio) development and is a target for glucocorticoids","volume":"100","author":"JM Hillegass","year":"2007","journal-title":"Toxicol Sci"},{"issue":"7","key":"pone.0276255.ref023","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/onc.2013.15","article-title":"ELF3 is a repressor of androgen receptor action in prostate cancer cells","volume":"33","author":"A Shatnawi","year":"2014","journal-title":"Oncogene"},{"issue":"1","key":"pone.0276255.ref024","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1038\/s41467-019-13295-y","article-title":"Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma","volume":"10","author":"KSS Enfield","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"pone.0276255.ref025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.onc.1203252","article-title":"Over-expression of ERT(ESX\/ESE-1\/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells","volume":"19","author":"J Chang","year":"2000","journal-title":"Oncogene"},{"issue":"10","key":"pone.0276255.ref026","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/labinvest.2011.100","article-title":"Elf3 plays a role in regulating bronchiolar epithelial repair kinetics following Clara cell-specific injury","volume":"91","author":"JR Oliver","year":"2011","journal-title":"Lab Invest"},{"issue":"20","key":"pone.0276255.ref027","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1038\/sj.onc.1201427","article-title":"A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer","volume":"15","author":"MJ Tymms","year":"1997","journal-title":"Oncogene"},{"issue":"5","key":"pone.0276255.ref028","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1074\/jbc.M006507200","article-title":"ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene","volume":"276","author":"S Rudders","year":"2001","journal-title":"J Biol Chem"},{"issue":"5","key":"pone.0276255.ref029","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/art.10942","article-title":"Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1","volume":"48","author":"F Grall","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"6","key":"pone.0276255.ref030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/cr.2008.57","article-title":"Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation","volume":"18","author":"J Wu","year":"2008","journal-title":"Cell Res"},{"issue":"22","key":"pone.0276255.ref031","doi-asserted-by":"crossref","first-page":"13588","DOI":"10.1093\/nar\/gku1146","article-title":"Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells","volume":"42","author":"SL Fossum","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pone.0276255.ref032","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/labinvest.2011.186","article-title":"Multiple roles of the epithelium-specific ETS transcription factor, ESE-1, in development and disease","volume":"92","author":"JR Oliver","year":"2012","journal-title":"Lab Invest"},{"issue":"13","key":"pone.0276255.ref033","doi-asserted-by":"crossref","first-page":"12794","DOI":"10.1074\/jbc.M308593200","article-title":"ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation","volume":"279","author":"C Brown","year":"2004","journal-title":"J Biol Chem"},{"issue":"2","key":"pone.0276255.ref034","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/jcp.21338","article-title":"ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes","volume":"215","author":"H Peng","year":"2008","journal-title":"J Cell Physiol"},{"issue":"5","key":"pone.0276255.ref035","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1074\/jbc.M111.265744","article-title":"E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.","volume":"287","author":"M Otero","year":"2012","journal-title":"J Biol Chem"},{"issue":"1","key":"pone.0276255.ref036","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/03008207.2016.1200566","article-title":"ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP\/p300-driven histone acetyltransferase activity","volume":"58","author":"M Otero","year":"2017","journal-title":"Connect Tissue Res"},{"issue":"5","key":"pone.0276255.ref037","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1182\/blood-2009-03-211391","article-title":"Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis","volume":"114","author":"G Wei","year":"2009","journal-title":"Blood"},{"issue":"11\u201312","key":"pone.0276255.ref038","doi-asserted-by":"crossref","first-page":"e23257","DOI":"10.1002\/dvg.23257","article-title":"Lessons from Drosophila Pointed, an ETS family transcription factor and key nuclear effector of the RTK signaling pathway","volume":"56","author":"P. Vivekanand","year":"2018","journal-title":"Genesis"},{"key":"pone.0276255.ref039","first-page":"118","article-title":"ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts","author":"Q Li","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"pone.0276255.ref040","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1053\/gast.2002.32990","article-title":"Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium","volume":"122","author":"AY Ng","year":"2002","journal-title":"Gastroenterology"},{"issue":"15","key":"pone.0276255.ref041","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/sj.onc.1203441","article-title":"Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation","volume":"19","author":"FH Brembeck","year":"2000","journal-title":"Oncogene"},{"issue":"1\u20132","key":"pone.0276255.ref042","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0925-4773(00)00419-6","article-title":"Ets family transcription factor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation","volume":"97","author":"N Yoshida","year":"2000","journal-title":"Mech Dev"},{"issue":"21","key":"pone.0276255.ref043","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1093\/nar\/25.21.4287","article-title":"The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis","volume":"25","author":"JM Andreoli","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"pone.0276255.ref044","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1096\/fasebj.12.14.1541","article-title":"The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution","volume":"12","author":"R Neve","year":"1998","journal-title":"Faseb j"},{"issue":"11","key":"pone.0276255.ref045","first-page":"3530","article-title":"Expression of the ETS transcription factor ELF3 in the retinal pigment epithelium","volume":"43","author":"AI Jobling","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pone.0276255.ref046","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1038\/s41598-020-59043-x","article-title":"Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defects","volume":"10","author":"S Sarmah","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"pone.0276255.ref047","doi-asserted-by":"crossref","first-page":"e10367","DOI":"10.1371\/journal.pone.0010367","article-title":"Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis","volume":"5","author":"S Sarmah","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"pone.0276255.ref048","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"10","key":"pone.0276255.ref049","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1242\/bio.20135546","article-title":"Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects","volume":"2","author":"S Sarmah","year":"2013","journal-title":"Biol Open"},{"issue":"10","key":"pone.0276255.ref050","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/dvdy.24015","article-title":"Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid","volume":"242","author":"S Sarmah","year":"2013","journal-title":"Dev Dyn"},{"issue":"2","key":"pone.0276255.ref051","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.alcohol.2014.11.001","article-title":"Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement","volume":"49","author":"P Muralidharan","year":"2015","journal-title":"Alcohol"},{"issue":"7\u20138","key":"pone.0276255.ref052","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.alcohol.2009.03.004","article-title":"Zebrafish fetal alcohol syndrome model: effects of ethanol are rescued by retinoic acid supplement","volume":"44","author":"JA Marrs","year":"2010","journal-title":"Alcohol"},{"issue":"1","key":"pone.0276255.ref053","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jcb.20652","article-title":"The control of chondrogenesis","volume":"97","author":"MB Goldring","year":"2006","journal-title":"J Cell Biochem"},{"issue":"4","key":"pone.0276255.ref054","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/154411130201300402","article-title":"Molecular dissection of craniofacial development using zebrafish","volume":"13","author":"PC Yelick","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"pone.0276255.ref055","first-page":"145","article-title":"Modulation of epidermal cell shaping and extracellular matrix during caudal fin morphogenesis in the zebra fish Brachydanio rerio","volume":"87","author":"PJ Dane","year":"1985","journal-title":"J Embryol Exp Morphol"},{"issue":"1","key":"pone.0276255.ref056","doi-asserted-by":"crossref","first-page":"13383","DOI":"10.1038\/s41598-019-50055-w","article-title":"ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects","volume":"9","author":"D Liedtke","year":"2019","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"pone.0276255.ref057","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0925-4773(98)00176-2","article-title":"The development of the paired fins in the zebrafish (Danio rerio)","volume":"79","author":"H Grandel","year":"1998","journal-title":"Mech Dev"},{"issue":"7303","key":"pone.0276255.ref058","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature09137","article-title":"Loss of fish actinotrichia proteins and the fin-to-limb transition","volume":"466","author":"J Zhang","year":"2010","journal-title":"Nature"},{"issue":"2","key":"pone.0276255.ref059","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ydbio.2017.07.024","article-title":"Dynamics of actinotrichia regeneration in the adult zebrafish fin","volume":"433","author":"D K\u00f6nig","year":"2018","journal-title":"Dev Biol"},{"issue":"5","key":"pone.0276255.ref060","doi-asserted-by":"crossref","first-page":"e0216370","DOI":"10.1371\/journal.pone.0216370","article-title":"Differential actinodin1 regulation in embryonic development and adult fin regeneration in Danio rerio","volume":"14","author":"HE Phan","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"pone.0276255.ref061","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ydbio.2011.03.014","article-title":"Actinotrichia collagens and their role in fin formation","volume":"354","author":"I Dur\u00e1n","year":"2011","journal-title":"Dev Biol"},{"key":"pone.0276255.ref062","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0070-2153(04)65009-5","article-title":"Zebrafish notochordal basement membrane: signaling and structure","volume":"65","author":"A Scott","year":"2005","journal-title":"Curr Top Dev Biol"},{"issue":"1","key":"pone.0276255.ref063","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/dev.110.1.115","article-title":"The mechanics of notochord elongation, straightening and stiffening in the embryo of Xenopus laevis","volume":"110","author":"DS Adams","year":"1990","journal-title":"Development"},{"issue":"23","key":"pone.0276255.ref064","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1242\/dev.00808","article-title":"Neural crest development is regulated by the transcription factor Sox9","volume":"130","author":"M Cheung","year":"2003","journal-title":"Development"},{"issue":"5","key":"pone.0276255.ref065","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1242\/dev.01674","article-title":"A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development","volume":"132","author":"YL Yan","year":"2005","journal-title":"Development"},{"issue":"1","key":"pone.0276255.ref066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2009.01.002","article-title":"Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation","volume":"329","author":"H Yokoi","year":"2009","journal-title":"Dev Biol"},{"key":"pone.0276255.ref067","unstructured":"RNA-seq of coding RNA: Human Developmental Biology Resource (HDBR) expression resource of prenatal human brain development. Available from: https:\/\/www.ebi.ac.uk\/gxa\/experiments\/E-MTAB-4840\/Results?geneQuery=%5B%7B%22value%22%3A%22ENSG00000163435%22%7D%5D&filterFactors=%7B%22DEVELOPMENTAL_STAGE%22%3A%5B%22Carnegie+Stage+14%22%5D%7D."},{"key":"pone.0276255.ref068","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fnana.2016.00086","article-title":"HDBR Expression: A Unique Resource for Global and Individual Gene Expression Studies during Early Human Brain Development","volume":"10","author":"SJ Lindsay","year":"2016","journal-title":"Front Neuroanat"},{"issue":"4\u20135","key":"pone.0276255.ref069","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/(SICI)1097-0177(199912)216:4\/5<420::AID-DVDY10>3.0.CO;2-C","article-title":"Xl erg: expression pattern and overexpression during development plead for a role in endothelial cell differentiation","volume":"216","author":"M Baltzinger","year":"1999","journal-title":"Dev Dyn"},{"issue":"1","key":"pone.0276255.ref070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2013.11.028","article-title":"Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations","volume":"386","author":"RS Gray","year":"2014","journal-title":"Dev Biol"},{"issue":"34","key":"pone.0276255.ref071","doi-asserted-by":"crossref","first-page":"E8037","DOI":"10.1073\/pnas.1722200115","article-title":"Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies","volume":"115","author":"C Gistelinck","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0276255.ref072","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.yexcr.2014.08.015","article-title":"Erg cooperates with TGF-\u03b2 to control mesenchymal differentiation","volume":"328","author":"MK Cox","year":"2014","journal-title":"Exp Cell Res"},{"issue":"6565","key":"pone.0276255.ref073","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/379534a0","article-title":"Down\u2019s syndrome-like skeletal abnormalities in Ets2 transgenic mice","volume":"379","author":"SH Sumarsono","year":"1996","journal-title":"Nature"},{"issue":"36","key":"pone.0276255.ref074","doi-asserted-by":"crossref","first-page":"21925","DOI":"10.1074\/jbc.M115.644864","article-title":"The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling","volume":"290","author":"C Wang","year":"2015","journal-title":"J Biol Chem"},{"issue":"12","key":"pone.0276255.ref075","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1242\/dev.121160","article-title":"Matrix metalloproteinase 9 modulates collagen matrices and wound repair","volume":"142","author":"DC LeBert","year":"2015","journal-title":"Development"},{"key":"pone.0276255.ref076","doi-asserted-by":"crossref","first-page":"134822","DOI":"10.1016\/j.neulet.2020.134822","article-title":"MMP-mediated modulation of ECM environment during axonal growth and NMJ development","volume":"724","author":"ZC Chan","year":"2020","journal-title":"Neurosci Lett"},{"issue":"5483","key":"pone.0276255.ref077","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.289.5483.1365","article-title":"Function of an axonal chemoattractant modulated by metalloprotease activity","volume":"289","author":"MJ Galko","year":"2000","journal-title":"Science"},{"issue":"5","key":"pone.0276255.ref078","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0955-0674(00)00248-9","article-title":"Matrix metalloproteinases: they\u2019re not just for matrix anymore","volume":"13","author":"LJ McCawley","year":"2001","journal-title":"Curr Opin Cell Biol"},{"issue":"18","key":"pone.0276255.ref079","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1523\/JNEUROSCI.22-18-08091.2002","article-title":"Metalloproteases and guidance of retinal axons in the developing visual system","volume":"22","author":"CA Webber","year":"2002","journal-title":"J Neurosci"},{"issue":"15","key":"pone.0276255.ref080","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1242\/dev.01908","article-title":"Matrix metalloproteinases are required for retinal ganglion cell axon guidance at select decision points","volume":"132","author":"CL Hehr","year":"2005","journal-title":"Development"},{"issue":"1","key":"pone.0276255.ref081","doi-asserted-by":"crossref","first-page":"e52915","DOI":"10.1371\/journal.pone.0052915","article-title":"Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development.","volume":"8","author":"E Janssens","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"pone.0276255.ref082","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1044-7431(03)00196-9","article-title":"MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum","volume":"24","author":"C Vaillant","year":"2003","journal-title":"Mol Cell Neurosci"},{"issue":"15","key":"pone.0276255.ref083","doi-asserted-by":"crossref","first-page":"E2189","DOI":"10.1073\/pnas.1525096113","article-title":"Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish","volume":"113","author":"TS Lisse","year":"2016","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0276255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T18:34:10Z","timestamp":1668623650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0276255"}},"subtitle":[],"editor":[{"given":"Eric A.","family":"Shelden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":83,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0276255","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]}}}