{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:08:24Z","timestamp":1791421704008,"version":"4.3.3"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>A convenient way to conduct pulmonary function tests while preventing infectious diseases was proposed, together with countermeasures for severe coronavirus disease 2019 (COVID-19). The correlation between diagnosis result and diagnosis result was examined for patients with mild chronic obstructive pulmonary disease (COPD) of the most abounding as a subject of spirometry, and the possibility of using this method as an alternative to spirometry was examined.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Setting<\/jats:title>\n<jats:p>This study was conducted in Kanagawa, Japan.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Participants<\/jats:title>\n<jats:p>Ten normal volunteers and 15 volunteers with mild COPD participated in this study.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Outcome measures<\/jats:title>\n<jats:p>All images were taken by EXAVISTA (Hitachi, Japan) between October 2019 and February 2020. Continuous fluoroscopic images were taken in 12.5 frames per second for 10\u201320 s per subject. Images that do not adopt the automatic image processing of the equipment and only carry out the signal correction of each pixel were used for the analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean total dose for all volunteers was 0.2 mGy. There was no major discrepancy in the detection of lung field geometry, and no diagnostic problems were noted by the radiologist and physician.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Existing X-ray cine imaging was used to extract frequency-tunable imaging. It is possible to identify abnormal regions on the images compared to spirometry, and it does not require maximum effort respiration; therefore, it is possible to perform a stable examination because the patient\u2019s physical condition and the ability of laboratory technicians on the day are less affected. This can also be used as a countermeasure in examining patients with infectious diseases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec007\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>UMIN <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/center6.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=UMIN000043868\" xlink:type=\"simple\">UMIN000043868<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0276859","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T18:41:30Z","timestamp":1668710490000},"page":"e0276859","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory frequency-tunable dynamic imaging for lung function: New exam method using chest X-ray cine imaging considering various respiratory diseases"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-7840","authenticated-orcid":true,"given":"Takehiko","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"pone.0276859.ref001","first-page":"1","article-title":"Novel corona virus (COVID-19) pandemic: current status and possible strategies for detection and treatment of the disease.","author":"S Bhagat","year":"2020","journal-title":"Expert Rev Anti Infect Ther"},{"key":"pone.0276859.ref002","first-page":"1","article-title":"An update on COVID-19 pandemic: the epidemiology, pathogenesis, prevention and treatment strategies","author":"HF Tsang","year":"2020","journal-title":"Expert Rev Anti Infect Ther."},{"key":"pone.0276859.ref003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2741\/874","article-title":"Insights into the COVID-19 pandemic: Origin, pathogenesis, diagnosis, and therapeutic interventions","volume":"13","author":"MM Berekaa","year":"2021","journal-title":"Front Biosci (Elite Ed)."},{"key":"pone.0276859.ref004","article-title":"Practical considerations for spirometry during the COVID-19 outbreak: Literature review and insights","author":"C Crimi","year":"2020","journal-title":"Pulmonology"},{"key":"pone.0276859.ref005","unstructured":"About measures against new coronavirus infection at the time of health examination. Japan Society of Health Evaluation and Promotion, Japna Society of Ningen Dock, Japan Anti-Tuberculosis Association, National Federation of Industrial Health Organization, Japan Cancer Society, All Japan Hospital Association, Japan Hospital Association, Japan Association of Health Service, 2020."},{"issue":"1","key":"pone.0276859.ref006","first-page":"16","article-title":"Lung Scintigraphy in COPDJannMortensenMD, Ronan M.G.Berg. Seminars in Nuclear Medicine","volume":"49","year":"2019"},{"issue":"1","key":"pone.0276859.ref007","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.chest.2019.06.015","article-title":"Subtyping COPD by Using Visual and Quantitative CT Imaging Features.","volume":"157","author":"J Park","year":"2020","journal-title":"Chest"},{"issue":"3","key":"pone.0276859.ref008","doi-asserted-by":"crossref","first-page":"00092","DOI":"10.1183\/23120541.00092-2020","article-title":"Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET.","volume":"6","author":"P Alter","year":"2020","journal-title":"ERJ Open Res"},{"key":"pone.0276859.ref009","first-page":"31","article-title":"Quantitative and qualitative evaluation of spirometry for COPD screening in general practice","volume":"77","author":"T Soumagne","year":"2020","journal-title":"Respir Med Res"},{"issue":"2","key":"pone.0276859.ref010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12194-016-0361-6","article-title":"Dynamic chest radiography: flat-panel detector (FPD) based functional X-ray imaging.","volume":"9","author":"R. Tanaka","year":"2016","journal-title":"Radiol Phys Technol"},{"key":"pone.0276859.ref011","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejrad.2016.12.014","article-title":"Difference in diaphragmatic motion during tidal breathing in a standing position between COPD patients and normal subjects: Time-resolved quantitative evaluation using dynamic chest radiography with flat panel detector system (\"dynamic X-ray phrenicography\").","volume":"87","author":"Y Yamada","year":"2017","journal-title":"Eur J Radiol"},{"key":"pone.0276859.ref012","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejrad.2018.12.023","article-title":"Decreased and slower diaphragmatic motion during forced breathing in severe COPD patients: Time-resolved quantitative analysis using dynamic chest radiography with a flat panel detector system","volume":"112","author":"T Hida","year":"2019","journal-title":"Eur J Radiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0276859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T18:41:50Z","timestamp":1668710510000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0276859"}},"subtitle":[],"editor":[{"given":"Aleksandra","family":"Barac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0276859","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,17]]}}}