{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:37:19Z","timestamp":1787593039303,"version":"build-2736575974"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073969"],"award-info":[{"award-number":["82073969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Provincial Key Science and Technology Project","award":["20200504003YY"],"award-info":[{"award-number":["20200504003YY"]}]},{"name":"Jilin Provincial Natural Science Foundation Project","award":["YDZJ202101ZYTS015"],"award-info":[{"award-number":["YDZJ202101ZYTS015"]}]},{"name":"Changchun Science and Technology Development Plan Project","award":["21ZGY13"],"award-info":[{"award-number":["21ZGY13"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204558"],"award-info":[{"award-number":["82204558"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key R & D plan of science and Technology Department of Jilin Province","award":["20220204078YY"],"award-info":[{"award-number":["20220204078YY"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Ginseng root rot caused by Fusarium oxysporum is serious disease that impacts ginseng production. In the present study, 145 strains of bacteria were isolated from the rhizosphere soil of healthy ginseng plants. Three strains with inhibitory activity against Fusarium oxysporum (accession number AF077393) were identified using the dual culture tests and designated as YN-42(L), YN-43(L), and YN-59(L). Morphological, physiological, biochemical, 16S rRNA gene sequencing and phylogenetic analyses were used to identify the strains as Bacillus subtilis [YN-42(L)] (accession number ON545980), Delftia acidovorans [YN-43(L)] (accession number ON545981), and Bacillus polymyxae [YN-59(L)] (accession number ON545982). All three isolates effectively inhibited the growth of Fusarium oxysporum in vitro and the antagonistic mechanism used by the three strains involved the secretion of multiple bioactive metabolites responsible for the hydrolysis of the fungal cell wall. All three biocontrol bacteria produce indoleacetic acid, which has a beneficial effect on plant growth. From our findings, all three antagonistic strains can be excellent candidates for ginseng root rot caused by the pathogenic fungus Fusarium oxysporum. These bacteria have laid the foundation for the biological control of ginseng root rot and for further research on the field control of ginseng pathogens.<\/jats:p>","DOI":"10.1371\/journal.pone.0277191","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T18:34:11Z","timestamp":1668105251000},"page":"e0277191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["The potential of novel bacterial isolates from healthy ginseng for the control of ginseng root rot disease (Fusarium oxysporum)"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-9365","authenticated-orcid":true,"given":"Qiong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changbao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"pone.0277191.ref001","first-page":"1","article-title":"Comparison of polysaccharides in ginseng root cultures and cultivated ginseng and establishment of high-content uronic acid plant synthesis system.","volume":"186","author":"JP He","year":"2022","journal-title":"Industrial Crops and Products"},{"key":"pone.0277191.ref002","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ijbiomac.2019.03.229","article-title":"Natural occurring polysaccharides from Panax ginseng C. A. Meyer: A review of isolation, structures, and bioactivities","author":"B Zhao","year":"2019","journal-title":"International Journal of Biological Macromolecules"},{"key":"pone.0277191.ref003","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1254\/jphs.93.458","article-title":"Anti-stress effects of Ginkgo biloba and Panax ginseng: A comparative study","volume":"4","author":"D Rai","year":"2003","journal-title":"Journal of Pharmacological Sciences"},{"key":"pone.0277191.ref004","first-page":"1295","article-title":"Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells","volume":"5","author":"CL Zhang","year":"2012","journal-title":"Molecular Medicine Reports"},{"issue":"5","key":"pone.0277191.ref005","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S1875-5364(22)60175-4","article-title":"Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats","volume":"20","author":"XS Wang","year":"2022","journal-title":"Chinese Journal of Natural Medicines"},{"issue":"3","key":"pone.0277191.ref006","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jep.2013.05.049","article-title":"Analgesic effects of glycoproteins from Panax ginseng root in mice","volume":"148","author":"Y Wang","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"pone.0277191.ref007","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.carbpol.2011.03.033","article-title":"biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: An overview","volume":"85","author":"Sun Y. 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Korean Journal of Soil Science &","volume":"45","author":"Kim Hae Jin Yoon Byung-Dae","year":"2012","journal-title":"Fertilizer"},{"key":"pone.0277191.ref010","first-page":"1","article-title":"Effect of steam-processing of the Panax ginseng root on its inducible activity on granulocyte-colony stimulating factor secretion in intestinal epithelial cells in vitro","volume":"287","author":"KW Ding","year":"2022","journal-title":"Journal of Ethnopharmacology"},{"key":"pone.0277191.ref011","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biocontrol.2018.05.021","article-title":"An investigation of biocontrol activity Pseudomonas and Bacillus strains against Panax ginseng root rot fungal phytopathogens","volume":"25","author":"K Durairaj","year":"2018","journal-title":"Biological Control"},{"key":"pone.0277191.ref012","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1093\/jxb\/erw079","article-title":"Hancock RD. Cross-tolerance to biotic and abiotic stresses in plants: A focus on resistance to aphid infestation","volume":"67","author":"CH Foyer","year":"2016","journal-title":"Journal of Experimental Botany"},{"issue":"6","key":"pone.0277191.ref013","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1094\/PDIS-09-13-0922-PDN","article-title":"First report of root rot caused by Fusarium redolens on ginseng (panax ginseng) in Jilin province of China.","volume":"98","author":"YM Guan","journal-title":"Plant Disease"},{"issue":"2","key":"pone.0277191.ref014","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1094\/PDIS-03-15-0273-PDN","article-title":"First Report of Ginseng (Panax ginseng) Root Rot Caused by Fusarium acuminatum in China.","volume":"100","author":"Y Wang","journal-title":"Plant Disease"},{"issue":"1","key":"pone.0277191.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5423\/PPJ.2009.25.1.001","article-title":"Different Structural Modifications 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polymyxa","volume":"38","author":"SN Sudha","year":"1999","journal-title":"Current Microbiology"},{"key":"pone.0277191.ref025","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jgr.2017.03.012","article-title":"An investigation of Panax ginseng Meyer growth promotion and the biocontrol potential of antagonistic bacteria against ginseng black spot","volume":"42","author":"Z Sun","year":"2018","journal-title":"Journal of Ginseng Research"},{"issue":"1","key":"pone.0277191.ref026","first-page":"266","article-title":"Screening and identification of antagonistic bacteria from vermicompost against Fusarium oxysporum f. sp. cucumerinum.","volume":"71","author":"DW Liu","year":"2021","journal-title":"Acta Agriculturae Scandinavica Section B\u2014Soil & Plant Science."},{"key":"pone.0277191.ref027","first-page":"1","article-title":"Characterization of a Bacillus velezensis strain isolated from Bolbostemmatis Rhizoma displaying strong antagonistic activities against a variety of rice pathogens","volume":"13","author":"JP Zhou","year":"2022","journal-title":"Frontiers in microbiology"},{"key":"pone.0277191.ref028","first-page":"195","volume-title":"Bergey\u2019s Manual of Determinative Bacteriology","author":"JG Holt","year":"1994"},{"issue":"9","key":"pone.0277191.ref029","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1080\/10408398.2017.1417235","article-title":"Exploitation of microbial antagonists for the control of postharvest diseases of fruits: a review.","volume":"59","author":"AS Dukare","year":"2019","journal-title":"Crit. Rev. 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Sp Ciceri.","volume":"38","author":"Suman","year":"2015","journal-title":"Legume research"},{"issue":"2","key":"pone.0277191.ref037","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1128\/aem.61.2.793-796.1995","article-title":"A Critical Examination of the Specificity of the Salkowski Reagent for Indolic Compounds Produced by Phytopathogenic Bacteria","volume":"61","author":"E Glickmann","year":"1995","journal-title":"Applied and Environmental Microbiology"},{"key":"pone.0277191.ref038","doi-asserted-by":"crossref","first-page":"333","DOI":"10.5423\/PPJ.2011.27.4.333","article-title":"Biocontrol efficacies of Bacillus species against Cylindrocarpon destructans causing ginseng root rot","volume":"27","author":"Y Jang","year":"2011","journal-title":"Plant Pathology Journal"},{"key":"pone.0277191.ref039","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jgr.2013.11.016","article-title":"Antagonistic Bacillus species as a biological control of ginseng root rot caused by Fusarium cf","volume":"38","author":"M Song","year":"2014","journal-title":"incarnatum. Journal of Ginseng Research"},{"key":"pone.0277191.ref040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10930-015-9645-7","article-title":"Structural studies of component of lysoamidase bacteriolytic complex from lysobacter sp","volume":"35","author":"S Tishchenko","year":"2016","journal-title":"XL1. Protein Journal"},{"issue":"5","key":"pone.0277191.ref041","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1021\/acsomega.0c05192","article-title":"Novel Method for the Quantitative Analysis of Protease Activity: The Casein Plate Method and Its Applications.","volume":"6","author":"X Zhang","year":"2021","journal-title":"ACS OMEGA"},{"key":"pone.0277191.ref042","first-page":"1","article-title":"Addressing challenges in production of cellulases for biomass hydrolysis: Targeted interventions into the genetics of cellulase producing fungi","author":"RK Sukumaran","year":"2021","journal-title":"Bioresource Technology"},{"issue":"3","key":"pone.0277191.ref043","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41579-019-0284-4","article-title":"Bacterial siderophores in community and host interactions","volume":"18","author":"J Kramer","year":"2019","journal-title":"Nature Reviews Microbiology"},{"key":"pone.0277191.ref044","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.foodchem.2015.10.006","article-title":"Identification and characterization of a novel chitinase with antifungal activity from \u02bbBaozhu\u2019 pear (Pyrus ussuriensis Maxim.).","volume":"196","author":"P Han","year":"2016","journal-title":"Food Chemistry"},{"issue":"4","key":"pone.0277191.ref045","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bjm.2017.03.002","article-title":"Isolation, identification, and biocontrol of antagonistic bacterium against Botrytis cinerea after tomato harvest","volume":"48","author":"JF Shi","year":"2017","journal-title":"Brazilian Journal of Microbiology"},{"key":"pone.0277191.ref046","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.soilbio.2010.01.015","article-title":"Influence of soil type and indigenous pathogenic fungi on bean hypocotyl rot caused by Rhizoctonia solani AG4 HGI in Cuba","volume":"42","author":"Y Nerey","year":"2010","journal-title":"Soil Biology & Biochemistry."},{"issue":"7","key":"pone.0277191.ref047","doi-asserted-by":"crossref","first-page":"e0254070","DOI":"10.1371\/journal.pone.0254070","article-title":"Screening of biocontrol bacteria against soft rot disease of Colocasia esculenta (L.) schott and its field application","volume":"16","author":"XF Dong","year":"2021","journal-title":"Plos One"},{"issue":"3","key":"pone.0277191.ref048","first-page":"126","article-title":"Isolation and Identification of Antagonistic Bacteria (RN-61, RN-88) against Ten Different Plant Pathogens.","volume":"42","author":"JJ Ren","year":"2014","journal-title":"Journal of Northeast Forestry University"},{"key":"pone.0277191.ref049","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cropro.2011.12.008","article-title":"Authentication and characterization of a candidate antagonistic bacterium against soft rot of Amorphophallus konjac","volume":"34","author":"JP Wu","year":"2012","journal-title":"Crop protection"},{"issue":"49","key":"pone.0277191.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/genomeA.01339-17","article-title":"Draft Genome Sequence of Polyaromatic Hydrocarbon-Degrading Bacterium Bacillus subtilis SR1, Which Has Plant Growth-Promoting Attributes.","volume":"5","author":"R Kotoky","year":"2017","journal-title":"Genome announcements."},{"issue":"3","key":"pone.0277191.ref051","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00374-014-0984-x","article-title":"Contribution of indole-3-acetic acid in the plant growth promotion by the rhizospheric strain Bacillus amyloliquefaciens SQR9","volume":"51","author":"JH Shao","year":"2015","journal-title":"Biology and Fertility of Soils"},{"issue":"6","key":"pone.0277191.ref052","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/evo.13230","article-title":"The evolution of siderophore production as a competitive trait","volume":"71","author":"R Niehus","year":"2017","journal-title":"Evolution"},{"issue":"6","key":"pone.0277191.ref053","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/evo.13230","article-title":"The evolution of siderophore production as a competitive trait","volume":"71","author":"R Niehus","year":"2017","journal-title":"Evolution"},{"key":"pone.0277191.ref054","first-page":"1","article-title":"Phage selection for bacterial cheats leads to population decline","volume":"282","author":"M Vasse","year":"2015","journal-title":"Proceedings of the Royal Society Biolo Sciences"},{"issue":"25","key":"pone.0277191.ref055","first-page":"4321","article-title":"A simple double-layered chrome azurol S agar (SD-CASA) plate assay to optimize the production of siderophores by a potential biocontrol agent Bacillus.","volume":"5","author":"QP Hu","year":"2012","journal-title":"African Journal of Microbiology. 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