{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:41:27Z","timestamp":1791805287774,"version":"4.3.4"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The correlates of quality of life originating from the demographic characteristics, comorbidities and sources of social support among persons living with tuberculosis remain underreported. The aim of this study was to examine the correlates of quality of life among persons living with tuberculosis within Greater Accra, Ghana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional survey design was used to assess the correlates of quality of life among 250 randomly sampled persons living with tuberculosis. Quality of life was assessed with the Quality of Life Brief Version (WHOQOL-BREF) questionnaire and correlates were derived using Spearman\n                      <jats:italic>rho<\/jats:italic>\n                      correlations. Chi-square analyses assessed associations among respondent characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All four quality of life domains (physical, psychological, social relationship and environmental) of persons living with tuberculosis were positively correlated. Furthermore, receiving social support from family or friends correlated positively with respondents\u2019 quality of life. Human Immunodeficiency Virus (HIV) infection and receiving social support mainly from work colleagues or religious institutions correlated negatively with respondents\u2019 quality of life domains. Other correlates of quality of life included age, pleuritis with pleural effusion, number of dependants and distance to tuberculosis treatment centres. Social support from family and friends corresponded with better quality of life among persons living with tuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The quality of life domains of persons living with tuberculosis are interrelated and can be enhanced by social support. Healthcare providers should involve the significant others of persons living with tuberculosis, human immunodeficiency virus and pleuritis with pleural effusion in their care to promote patients\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0277192","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T13:28:02Z","timestamp":1667568482000},"page":"e0277192","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Correlates of quality of life among persons living with tuberculosis: A cross-sectional study"],"prefix":"10.1371","volume":"17","author":[{"given":"Eric","family":"Tornu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-0149","authenticated-orcid":true,"given":"Louisa","family":"Quarcoopome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"pone.0277192.ref001","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.ijid.2021.02.107","article-title":"Global Tuberculosis Report 2020 \u2013Reflections on the Global TB burden, treatment and prevention efforts","volume":"113","author":"J Chakaya","year":"2021","journal-title":"Int J Infect Dis"},{"key":"pone.0277192.ref002","unstructured":"World Health Organization. TB profile: Global. 24 Feb 2022 [cited 24 Feb 2022]. Available: https:\/\/worldhealthorg.shinyapps.io\/tb_profiles\/?_inputs_&lan=%22EN%22&entity_type=%22group%22&group_code=%22global%22"},{"key":"pone.0277192.ref003","unstructured":"World Health Organization. Tuberculosis profile: WHO African Region. 21 Feb 2022 [cited 21 Feb 2022]. Available: https:\/\/worldhealthorg.shinyapps.io\/tb_profiles\/?_inputs_&lan=%22EN%22&entity_type=%22group%22&group_code=%22AFR%22"},{"key":"pone.0277192.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5981574","article-title":"Diabetes Mellitus as Hub for Tuberculosis Infection: A Snapshot","volume":"2016","author":"R Pal","year":"2016","journal-title":"Int J Chronic Dis"},{"key":"pone.0277192.ref005","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4314\/gmj.v54i3.10","article-title":"Management of TB\/HIV co-infection: the state of the evidence","volume":"54","author":"K Torpey","year":"2020","journal-title":"Ghana Med J"},{"key":"pone.0277192.ref006","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/resp.13673","article-title":"Tuberculous pleural effusion","volume":"24","author":"JA Shaw","year":"2019","journal-title":"Respirology"},{"key":"pone.0277192.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5152\/ttd.2014.001","article-title":"Tuberculous Pleural Effusion","volume":"16","author":"LA Cohen","year":"2015","journal-title":"Turkish Thorac J"},{"key":"pone.0277192.ref008","unstructured":"World Health Organization. Ghana Tuberculosis Profile, 2021. 2021 [cited 18 Oct 2021]. Available: https:\/\/worldhealthorg.shinyapps.io\/tb_profiles\/?_inputs_&entity_type=%22country%22&lan=%22EN%22&iso2=%22GH%22"},{"key":"pone.0277192.ref009","unstructured":"Ghana National TB Control Programme. Background of Programme. 2021 [cited 16 Dec 2021]. Available: http:\/\/www.tbghana.gov.gh\/history.php"},{"key":"pone.0277192.ref010","unstructured":"Centers for Disease Control and Prevention. Treatment Highlights of Drug-Susceptible Tuberculosis. 11 Aug 2016 [cited 21 Feb 2022]. Available: https:\/\/www.cdc.gov\/tb\/topic\/treatment\/guidelinehighlights.htm"},{"key":"pone.0277192.ref011","article-title":"The National Tuberculosis Health Sector Strategic Plan for Ghana: 2015\u20132020","author":"Ghana Ministry of Health","year":"2015","journal-title":"Minist Heal"},{"key":"pone.0277192.ref012","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/0277-9536(95)00112-K","article-title":"The World Health Organization quality of life assessment (WHOQOL): Position paper from the World Health Organization","volume":"41","author":"World Health Organization","year":"1995","journal-title":"Soc Sci Med"},{"key":"pone.0277192.ref013","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1016\/j.jctube.2021.100235","article-title":"Health related quality of life and associated factors with medication adherence among tuberculosis patients in selected districts of Gandaki Province of Nepal","volume":"23","author":"RK Yadav","year":"2021","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"pone.0277192.ref014","first-page":"00251","article-title":"Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study","volume":"7","author":"AR Febi","year":"2021","journal-title":"ERJ Open Res"},{"key":"pone.0277192.ref015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2147\/PROM.S316337","article-title":"Health-Related Quality of Life in Tuberculosis Patients in Eritrea: Comparison Among Drug-Susceptible and Rifampicin\/Multidrug-Resistant Tuberculosis Patients","volume":"12","author":"ZZ Araia","year":"2021","journal-title":"Patient Relat Outcome Meas"},{"key":"pone.0277192.ref016","doi-asserted-by":"crossref","first-page":"100093","DOI":"10.1016\/j.jctube.2019.100093","article-title":"Quality of life and its effective factors in tuberculosis patients receiving directly observed treatment short-course (DOTS)","volume":"15","author":"S Salehitali","year":"2019","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"pone.0277192.ref017","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s11136-020-02717-w","article-title":"Quality of life and associated factors among patients with tuberculosis at the University of Gondar comprehensive specialized hospital, Ethiopia","volume":"30","author":"A Dires","year":"2021","journal-title":"Qual Life Res"},{"key":"pone.0277192.ref018","doi-asserted-by":"crossref","first-page":"A601","DOI":"10.1016\/j.jval.2014.08.2086","article-title":"Health-Related Quality of Life Among Tuberculosis Patients in Pakistan: A Cross Sectional Study Using WHOQOL-BREF","volume":"17","author":"MS Iqbal","year":"2014","journal-title":"Value Heal"},{"key":"pone.0277192.ref019","doi-asserted-by":"crossref","first-page":"24236","DOI":"10.1038\/s41598-021-03811-w","article-title":"The relationship among social support, experienced stigma, psychological distress, and quality of life among tuberculosis patients in China","volume":"11","author":"X Chen","year":"2021","journal-title":"Sci Rep"},{"key":"pone.0277192.ref020","volume-title":"Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis","author":"World Health Organization","year":"2014"},{"key":"pone.0277192.ref021","doi-asserted-by":"crossref","first-page":"e90051","DOI":"10.1371\/journal.pone.0090051","article-title":"The Roles of Different Sources of Social Support on Emotional Well-Being among Chinese Elderly","volume":"9","author":"H Li","year":"2014","journal-title":"PLoS One"},{"key":"pone.0277192.ref022","unstructured":"UNAIDS. Building faith-based partnerships to end AIDS and TB among children and adolescents. 28 Sep 2018 [cited 15 Feb 2022]. Available: https:\/\/www.unaids.org\/en\/resources\/presscentre\/featurestories\/2018\/september\/building-faith-based-partnerships-to-end-aids-and-tb-among-children-and-adolescents"},{"key":"pone.0277192.ref023","first-page":"1","article-title":"The impact of social support on the health-related quality of life of adult patients with tuberculosis in Harare, Zimbabwe: A cross-sectional survey 11 Medical and Health Sciences 1117 Public Health and Health Services","volume":"11","author":"C Zarova","year":"2018","journal-title":"BMC Res Notes"},{"key":"pone.0277192.ref024","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12955-016-0442-6","article-title":"Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis\u2013a systematic review of global literature with focus on South Africa","volume":"14","author":"T Kastien-Hilka","year":"2016","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0277192.ref025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4269\/ajtmh.21-0494","article-title":"Health-Related Quality of Life of Tuberculosis Patients and the Role of Socioeconomic Factors: A Mixed-Method Study","volume":"106","author":"M Rafiq","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0277192.ref026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12955-020-01330-2","article-title":"Multivariate multilevel modeling of quality of life dynamics of HIV infected patients","volume":"18","author":"ZG Dessie","year":"2020","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0277192.ref027","doi-asserted-by":"crossref","first-page":"100324","DOI":"10.1016\/j.jctube.2022.100324","article-title":"Health-related quality of life of persons living with tuberculosis: A cross-sectional study","volume":"28","author":"L Quarcoopome","year":"2022","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"pone.0277192.ref028","unstructured":"Ghana National TB Control Programme. Directly Observed Treatment Centres. 2021 [cited 16 Dec 2021]. Available: http:\/\/www.tbghana.gov.gh\/dotcenters.php"},{"key":"pone.0277192.ref029","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A Power Primer","volume":"112","author":"J. Cohen","year":"1992","journal-title":"Psychol Bull [PsycARTICLES]"},{"key":"pone.0277192.ref030","volume-title":"WHOQOL-BREF: introduction, administration, scoring and generic version of the assessment: field trial version, December","author":"World Health Organization","year":"1996"},{"key":"pone.0277192.ref031","article-title":"Nursing Research: Generating and Assessing Evidence for Nursing Practice","author":"DF Polit","year":"2017","journal-title":"Wolters Kluwer Health"},{"key":"pone.0277192.ref032","volume-title":"SPSS survival manual: A step by step guide to data analysis using IBM SPSS","author":"J. Pallant","year":"2020"},{"key":"pone.0277192.ref033","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/picr.PICR_99_18","article-title":"Quality of life among HIV-tuberculosis co-infected patients","volume":"10","author":"DK Jha","year":"2019","journal-title":"Perspect Clin Res"},{"key":"pone.0277192.ref034","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1477-7525-7-105","article-title":"Tuberculosis and HIV co-infection: its impact on quality of life","volume":"7","author":"A Deribew","year":"2009","journal-title":"Health Qual Life Outcomes"},{"key":"pone.0277192.ref035","doi-asserted-by":"crossref","first-page":"100121","DOI":"10.1016\/j.jctube.2019.100121","article-title":"Quality of life with tuberculosis","volume":"17","author":"AN Aggarwal","year":"2019","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"pone.0277192.ref036","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1186\/s12889-018-5474-x","article-title":"Gender difference in health related quality of life and associated factors among people living with HIV\/AIDS attending anti-retroviral therapy at public health facilities, western Ethiopia: Comparative cross sectional study","volume":"18","author":"DY Gebremichael","year":"2018","journal-title":"BMC Public Health"},{"key":"pone.0277192.ref037","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2147\/PPA.S269577","article-title":"Health-Related Quality of Life and Associated Factors Among Adult HIV Mono-Infected and TB\/HIV Co-Infected Patients in Public Health Facilities in Northeast Ethiopia: A Comparative Cross-Sectional Study","volume":"14","author":"T Hailu","year":"2020","journal-title":"Patient Prefer Adherence"},{"key":"pone.0277192.ref038","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4314\/mmj.v30i4.12","article-title":"Health-Related Quality of Life (HRQoL) scores vary with treatment and may identify potential defaulters during treatment of tuberculosis","volume":"30","author":"AO Olufemi","year":"2018","journal-title":"Malawi Med J"},{"key":"pone.0277192.ref039","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/thoraxjnl-2020-215338","article-title":"The long term effect of pulmonary tuberculosis on income and employment in a low income, urban setting","volume":"76","author":"J Meghji","year":"2021","journal-title":"Thorax"},{"key":"pone.0277192.ref040","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1080\/09540121.2012.672719","article-title":"Social constraints to TB\/HIV healthcare: accounts from coinfected patients in South Africa","volume":"24","author":"A Daftary","year":"2012","journal-title":"AIDS Care"},{"key":"pone.0277192.ref041","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4046\/trd.2017.80.1.69","article-title":"Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis","volume":"80","author":"APC Dos Santos","year":"2017","journal-title":"Tuberc Respir Dis (Seoul)"},{"key":"pone.0277192.ref042","first-page":"100247","article-title":"Determinants of student nurses\u2019 self-assessed TB\/HIV coinfection care skill-competence in Accra, Ghana","volume":"13","author":"E Tornu","year":"2020","journal-title":"Int J Africa Nurs Sci"},{"key":"pone.0277192.ref043","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4081\/jphia.2014.366","article-title":"Factors influencing quality of life and predictors of low quality of life scores in patients on treatment for pulmonary tuberculosis: A cross sectional study","volume":"5","author":"OO Adeyeye","year":"2014","journal-title":"J Public Health Africa"},{"key":"pone.0277192.ref044","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/jgid.jgid_136_18","article-title":"Assessment of health-related quality of life among tuberculosis patients in a public primary care facility in Indonesia","volume":"11","author":"I Sartika","year":"2019","journal-title":"J Glob Infect Dis"},{"key":"pone.0277192.ref045","doi-asserted-by":"crossref","first-page":"e06873","DOI":"10.1016\/j.heliyon.2021.e06873","article-title":"Depression, coping skills, and quality of life among Jordanian adults during the initial outbreak of COVID-19 pandemic: cross sectional study","volume":"7","author":"Y Al-Shannaq","year":"2021","journal-title":"Heliyon"},{"key":"pone.0277192.ref046","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/resp.13303","article-title":"Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people","volume":"23","author":"WW Yew","year":"2018","journal-title":"Respirology"},{"key":"pone.0277192.ref047","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/13548500902730127","article-title":"Health professionals as stigmatisers of tuberculosis: Insights from community members and patients with TB in an urban district in Ghana","volume":"14","author":"EA Dodor","year":"2009","journal-title":"Psychol Heal Med"},{"key":"pone.0277192.ref048","first-page":"1","article-title":"Perspectives on TB patients\u2019 care and support: A qualitative study conducted in Accra Metropolis, Ghana","volume":"15","author":"FT Gyimah","year":"2019","journal-title":"Global Health"},{"key":"pone.0277192.ref049","doi-asserted-by":"crossref","first-page":"e0227293","DOI":"10.1371\/journal.pone.0227293","article-title":"Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers","volume":"15","author":"SB Marahatta","year":"2020","journal-title":"PLoS One"},{"key":"pone.0277192.ref050","first-page":"377","article-title":"Pleural Effusion in Adults\u2014Etiology, Diagnosis, and Treatment","volume":"116","author":"B Jany","year":"2019","journal-title":"Dtsch Arztebl Int"},{"key":"pone.0277192.ref051","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/9781119028994.ch183","article-title":"Thoracocentesis","author":"M Bucknoff","year":"2018","journal-title":"Textb Small Anim Emerg Med"},{"key":"pone.0277192.ref052","first-page":"1","article-title":"Community Contribution to Tuberculosis Care in the Krachi West District of Ghana: A Qualitative Study","volume":"2019","author":"SA Addy","year":"2019","journal-title":"Tuberc Res Treat"},{"key":"pone.0277192.ref053","doi-asserted-by":"crossref","first-page":"712","DOI":"10.5588\/ijtld.19.0734","article-title":"Effects of co-morbidities on health-related quality of life in Filipino persons with tuberculosis","volume":"24","author":"T Edwards","year":"2020","journal-title":"Int J Tuberc Lung Dis"},{"key":"pone.0277192.ref054","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1007\/s11136-018-1954-9","article-title":"Health-related quality of life among pulmonary tuberculosis patients in Pakistan","volume":"27","author":"A. Saleem S","year":"2018","journal-title":"Qual Life Res"},{"key":"pone.0277192.ref055","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s11136-013-0571-x","article-title":"Factors associated with health-related quality of life among pulmonary tuberculosis patients in Manila, the Philippines","volume":"23","author":"S Masumoto","year":"2014","journal-title":"Qual Life Res"},{"key":"pone.0277192.ref056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12913-016-1545-9","article-title":"Coping with tuberculosis and directly observed treatment: A qualitative study among patients from South India","volume":"16","author":"V Yellappa","year":"2016","journal-title":"BMC Health Serv Res"},{"key":"pone.0277192.ref057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-020-05354-3","article-title":"The effects of family, society and national policy support on treatment adherence among newly diagnosed tuberculosis patients: A cross-sectional study","volume":"20","author":"X Chen","year":"2020","journal-title":"BMC Infect Dis"},{"key":"pone.0277192.ref058","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.enfcli.2019.04.072","article-title":"Evaluation of impact self-management counseling on health-seeking behavior\u2019s self-efficacy pulmonary tuberculosis outpatients","volume":"29","author":"M Jauhar","year":"2019","journal-title":"Enferm Clin"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0277192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T13:29:04Z","timestamp":1667568544000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0277192"}},"subtitle":[],"editor":[{"given":"Emily","family":"Chenette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0277192","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]}}}