{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:34:57Z","timestamp":1770492897367,"version":"3.49.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>More than one-third of reproductive aged women in Ethiopia use hormonal contraceptives to prevent conception. The present study aimed to compare the hematological parameters of reproductive-age women taking hormonal contraceptives at the University of Gondar Comprehensive Specialized Referral Hospital, Northwest Ethiopia in 2021.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A comparative cross-sectional study was conducted from April to June 2021. A total of 240 study participants were recruited by using a consecutive sampling technique. Data on socio-demographic variables and clinical data were collected through face-to-face interviews using a structured questionnaire and medical record reviews, respectively. Three milliliter venous blood was collected for complete blood count analysis using Unicel DxH 800 coulter hematology analyzer. Data was entered into Epi-data 4.4.3.1 version then exported to IBM SPSS v25 for analysis. Kruskal-Wallis H, Dunn-Bonferroni pairwise comparison test, and Spearman\u2019s correlation analysis were used for inferential statistics. P&lt;0.05 were considered statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>The median and interquartile range of platelet count among combined oral contraceptive users was 285(238\u2013332) which is significantly higher than that of depot medroxyprogesterone acetate users 246(220\u2013226) (p = 0.010), implant user 247(221\u2013297) (p = 0.034), and controls 256(224\u2013278) (p = 0.015). The result also showed long-term use of implant negatively correlated with red blood cell count (p = 0.033).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This finding concludes that combined oral contraceptive users had a higher platelet counts than controls while long-term use of implants can result in low red blood cells count. Therefore, a baseline evaluation of complete blood count in women desiring contraceptive methods would also be recommended.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0277254","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T18:54:18Z","timestamp":1667933658000},"page":"e0277254","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hematological parameters of reproductive-age women using hormonal contraceptives at University of Gondar Comprehensive Specialized Referral Hospital, Northwest Ethiopia: A comparative cross-sectional 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Terefe","family":"Gashaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulugeta","family":"Melku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"issue":"6","key":"pone.0277254.ref001","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s13224-011-0107-7","article-title":"Contraceptive methods: needs, options and utilization","volume":"61","author":"R Jain","year":"2011","journal-title":"J Obstet Gynaecol India"},{"issue":"01","key":"pone.0277254.ref002","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4236\/jbm.2016.41013","article-title":"Effect of Hormonal Contraceptives on the Total Antioxidants Status of Women from Isolo, Lagos State, Nigeria","volume":"4","author":"EN Adejumo","year":"2016","journal-title":"Journal of Biosciences and 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