{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:33:24Z","timestamp":1790238804083,"version":"4.1.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The aim of this study was to estimate the prevalence of selective immunoglobulin A deficiency (SIgAD) among children with type 1 diabetes mellitus (DM) in Ternopil region (western Ukraine). Serum IgA levels were measured in 240 patients aged 4\u201317 years with DM and in 324 children of a control group of the same age. Normal IgA level was observed in 210 (87.5%) patients, increased\u2014in 18 (7.5%), decreased (lower than the age reference value)\u2014in 12 (5.0%) patients with DM. The mean IgA level in patients with DM was 152.11\u00b173.78 mg\/dL. SIgAD criteria were met by 7 (2.9%) children with DM, but none of the children of the control group met the SIgAD criteria. Female \/ male ratio among the patients with SIgAD was 1\/6. There was no history of recurrent infections in these patients. No correlation between IgA and HbA1c levels was detected. Autoimmune thyroiditis was observed in 42.9% of patients with DM and SIgAD, and in 3.5% of patients with DM and normal or increased IgA levels. Thus, the prevalence of selective IgA deficiency in children with DM in Ternopil region (Ukraine) is 2.9% (1:34). This study shows that patients with low IgA levels need further re-examination of IgA levels to exclude SIgAD. Children with SIgAD and DM should be monitored for autoimmune manifestations that may affect the course and consequences of the disease.<\/jats:p>","DOI":"10.1371\/journal.pone.0277273","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T19:02:52Z","timestamp":1668711772000},"page":"e0277273","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Selective immunoglobulin A deficiency in children with diabetes mellitus: Data from a medical center in Ukraine"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-0040","authenticated-orcid":true,"given":"Oksana","family":"Boyarchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesya","family":"Dobrovolska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halyna","family":"Svystunovych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"issue":"1","key":"pone.0277273.ref001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/sji.12499","article-title":"Selective IgA Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management","volume":"85","author":"R Yazdani","year":"2017","journal-title":"Scand J Immunol"},{"issue":"5","key":"pone.0277273.ref002","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1023\/A:1023247117133","article-title":"Primary antibody deficiency in Arabs: first report from eastern Saudi Arabia","volume":"18","author":"RA al-Attas","year":"1998","journal-title":"J Clin Immunol"},{"issue":"1","key":"pone.0277273.ref003","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10875-009-9357-x","article-title":"Selective IgA deficiency","volume":"30","author":"L. 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