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Genetic studies have linked <jats:italic>Ptprd<\/jats:italic> to several neuropsychiatric phenotypes, including Restless Leg Syndrome (RLS), opioid abuse disorder, and antipsychotic-induced weight gain. Genome-wide association studies (GWAS) of either pediatric obsessive-compulsive traits, or Obsessive-Compulsive Disorder (OCD), have identified loci near PTPRD as genome-wide significant, or strongly suggestive for this trait. We assessed <jats:italic>Ptprd<\/jats:italic> wild-type (WT), heterozygous (HT), and knockout (KO) mice for behavioral dimensions that are altered in OCD, including anxiety and exploration (open field test, dig test), perseverative behavior (splash-induced grooming, spatial <jats:italic>d<\/jats:italic>), sensorimotor gating (prepulse inhibition), and home cage goal-directed behavior (nest building). No effect of genotype was observed in any measure of the open field test, dig test, or splash test. However, <jats:italic>Ptprd<\/jats:italic> KO mice of both sexes showed impairments in nest building behavior. Finally, female, but not male, <jats:italic>Ptprd<\/jats:italic> KO mice showed deficits in prepulse inhibition, an operational measure of sensorimotor gating that is reduced in female, but not male, OCD patients. Our results indicate that constitutive lack of <jats:italic>Ptprd<\/jats:italic> may contribute to the development of certain domains that are altered OCD, including goal-directed behavior, and reduced sensorimotor gating specifically in females.<\/jats:p>","DOI":"10.1371\/journal.pone.0277446","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T17:30:00Z","timestamp":1684517400000},"page":"e0277446","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-4200","authenticated-orcid":true,"given":"Emily 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