{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:58Z","timestamp":1787022118381,"version":"build-2736575974"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Michelin Corporate Foundation"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>COVID 19 is often associated with hypercoagulability and thromboembolic (TE) events. The aim of this study was to assess the characteristics of hypercoagulability and its relationship with new-onset TE events and the composite outcome of need for intubation and\/or death in intensive care unit (ICU) patients admitted for COVID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Monocentric, intensive care, University Hospital of Clermont Ferrand, France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Patients admitted to intensive care from January 2020 to May 2021 for COVID-19 pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>\n                      Standard hemostatic tests and rotational thromboelastometry (ROTEM) were performed on admission and on day 4. Hypercoagulability was defined by at least one of the following criteria: D-dimers &gt; 3000 \u03bcg\/dL, fibrinogen &gt; 8 g\/L, EXTEM CFT below the normal range, EXTEM A5, MCF, Li 60 above the normal range, and EXTEM G-score ((5000 x MCF) \/ (100-MCF)) \u2265 11 dyne\/cm\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec006\">\n                    <jats:title>Measurements and main results<\/jats:title>\n                    <jats:p>Of the 133 patients included, 17 (12.7%) developed new-onset TE events, and 59 (44.3%) required intubation and\/or died in the ICU. ROTEM was performed in 133 patients on day 1 and in 67 on day 4. Hypercoagulability was present on day 1 in 115 (86.4%) patients. None of the hypercoagulability indices were associated with subsequent new-onset TE events on days 1 and 4 nor with the need for intubation and\/or ICU death. Hyperfibrinogenemia &gt; 8g\/dL, higher D-dimers and higher EXTEM Li 60 on day 4 were predictive of need for intubation and\/or of ICU death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec007\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study confirmed that most COVID-19 ICU patients have hypercoagulability on admission and almost all on day 4. Hyperfibrinogenemia or fibrinolysis shutdown on day 4 were associated with unfavorable outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0277544","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T09:42:38Z","timestamp":1669282958000},"page":"e0277544","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hypercoagulability in critically ill patients with COVID 19, an observational prospective 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