{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:48:57Z","timestamp":1782377337754,"version":"3.54.5"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>This study aims to reveal whether the optic nerve sheath diameter (ONSD) increases in hepatic encephalopathy (HE) patients, and to determine ONSD is associated with the poor prognosis of patients with HE.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and material<\/jats:title>\n<jats:p>In this retrospective case-control study, HE patients who underwent cranial computerized tomography (CT) were included in the case group; and the patients who underwent CT for other reasons for the same age and gender and were normally interpreted were included in the control group. ONSD measurements in the case and control groups and clinical grades of HE with in-hospital mortality and ONSD measurements were compared in the case group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>This study was done with 74 acute HE patients and 74 control patients. The mean age was 62.9 \u00b1 11.0 years and 67.6% of patients were male in both groups. The ONSD in the case group was higher than the control group (5.27-mm \u00b1 0.82 vs 4.73 mm \u00b1 0.57, <jats:italic>p<\/jats:italic> &lt;0.001). In the case group, the ONSD was 5.30 mm \u00b1 0.87 in survivors, and 5.21 \u00b1 0.65 in non-survivors (<jats:bold><jats:italic>P<\/jats:italic><\/jats:bold> = 0.670). There was no significant difference between the West Haven HE grade (<jats:bold><jats:italic>P<\/jats:italic><\/jats:bold> = 0.348) and Child-Pugh Score (<jats:bold><jats:italic>P<\/jats:italic><\/jats:bold> = 0.505) with ONSD measurements.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We have shown that ONSD increases in HE patients compared to the control group. ONSD was not related to the Child-Pugh Score, HE grade, and in-hospital mortality.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0277643","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T18:37:01Z","timestamp":1668623821000},"page":"e0277643","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Optic nerve sheath diameter in patients with hepatic encephalopathy"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-9031","authenticated-orcid":true,"given":"Nese","family":"Colak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Bayrak Basakci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Aksay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet Kursat","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Karabay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"issue":"4","key":"pone.0277643.ref001","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2478\/jtim-2020-0034","article-title":"Hepatic Encephalopathy: Diagnosis and Management","volume":"8","author":"L Ridola","year":"2020","journal-title":"J Transl Int Med"},{"issue":"12","key":"pone.0277643.ref002","doi-asserted-by":"crossref","first-page":"e1278","DOI":"10.1097\/CCM.0000000000004689","article-title":"A Prospective Study of Optic Nerve Ultrasound for the Detection of Elevated Intracranial Pressure in Severe Traumatic Brain Injury","volume":"48","author":"D Agrawal","year":"2020","journal-title":"Crit Care Med"},{"issue":"1","key":"pone.0277643.ref003","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13089-020-00196-1","article-title":"Optic nerve sheath diameter sonography during the acute stage of intracerebral hemorrhage: a potential role in monitoring neurocritical patients","volume":"12","author":"M Bender","year":"2020","journal-title":"Ultrasound J"},{"key":"pone.0277643.ref004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.resuscitation.2019.10.004","article-title":"Relationship between optic nerve sheath diameter measured by magnetic resonance imaging, intracranial pressure, and neurological outcome in cardiac arrest survivors who underwent targeted temperature management","volume":"145","author":"C Kang","year":"2019","journal-title":"Resuscitation"},{"issue":"4","key":"pone.0277643.ref005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tjem.2019.07.001","article-title":"Association of optic nerve sheath diameter in ocular ultrasound with prognosis in patients presenting with acute stroke symptoms","volume":"19","author":"J Seyedhosseini","year":"2019","journal-title":"Turk J Emerg Med"},{"issue":"7","key":"pone.0277643.ref006","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1524-6175.2005.04123.x","article-title":"Hypertensive crisis with optic disc edema and cerebral white matter lesions","volume":"7","author":"J. 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