{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:23:14Z","timestamp":1789647794968,"version":"4.0.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016905","name":"Hugh Green Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016905","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ian and Sue Parton"},{"DOI":"10.13039\/100000864","name":"Michael J. 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Our previous work has shown that pericytes\u2014vascular mural cells that regulate the blood-brain barrier\u2014contain \u03b1-syn aggregates in human PD brains. Here, we demonstrate that pericytes efficiently internalise fibrillar \u03b1-syn irrespective of being in a monoculture or mixed neuronal cell culture. Pericytes cleave fibrillar \u03b1-syn aggregates (Fibrils, Ribbons, fibrils65, fibrils91 and fibrils110), with cleaved \u03b1-syn remaining present for up to 21 days. The number of \u03b1-syn aggregates\/cell and average aggregate size depends on the type of strain, but differences disappear within 5 five hours of treatment. Our results highlight the role brain vasculature may play in reducing \u03b1-syn aggregate burden in PD.<\/jats:p>","DOI":"10.1371\/journal.pone.0277658","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T21:03:42Z","timestamp":1668805422000},"page":"e0277658","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Human pericytes degrade diverse \u03b1-synuclein aggregates"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9392-3327","authenticated-orcid":true,"given":"Birger Victor","family":"Dieriks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Highet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ania","family":"Alik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Bellande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-1445","authenticated-orcid":true,"given":"Taylor J.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas I-H","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schweder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L. 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