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A total of 396 cases along with 449 specimens were received for antibiotic susceptibility testing at a public university veterinary diagnostic laboratory in Malaysia between 2015 and 2017. <jats:italic>Escherichia coli<\/jats:italic> was the most frequently isolated (n = 101, 13%) bacteria, followed by <jats:italic>Staphylococcus pseudintermedius<\/jats:italic> (n = 97, 12%) and <jats:italic>Streptococcus canis<\/jats:italic> (n = 62, 8%). In cats, <jats:italic>S<\/jats:italic>. <jats:italic>pseudintermedius<\/jats:italic> isolates were highly resistant to azithromycin (90%), while the <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> isolates were highly resistant to doxycycline (90%), tetracycline (81%), and cephalexin (75%). About 55% of <jats:italic>S<\/jats:italic>. <jats:italic>pseudintermedius<\/jats:italic> and 82% of <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> were multi-drug resistant (MDR). In dogs, <jats:italic>S<\/jats:italic>. <jats:italic>intermedius<\/jats:italic> isolates were highly resistant to aminoglycosides neomycin (90.9%) and gentamicin (84.6%), and tetracycline (75%). Whereas the <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> isolates were highly resistant to cephalexin (82.1%) and amoxicillin\/clavulanic acid (76.5%). MDR was observed in 60% of <jats:italic>S<\/jats:italic>. <jats:italic>intermedius<\/jats:italic> and 72% of <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> from dogs. Generally, the bacterial isolates from cats demonstrated higher levels of resistance to multiple antibiotics compared to those from dogs.<\/jats:p>","DOI":"10.1371\/journal.pone.0277664","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T18:26:25Z","timestamp":1670437585000},"page":"e0277664","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["High prevalence of antimicrobial resistance and multidrug resistance among bacterial isolates from diseased pets: Retrospective laboratory data (2015\u20132017)"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-4428","authenticated-orcid":true,"given":"Nurul Asyiqin","family":"Haulisah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-9906","authenticated-orcid":true,"given":"Latiffah","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6977-9815","authenticated-orcid":true,"given":"Saleh Mohammed","family":"Jajere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-9915","authenticated-orcid":true,"given":"Nur Indah","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Khairani","family":"Bejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"issue":"4","key":"pone.0277664.ref001","first-page":"957","article-title":"Public health risk of antimicrobial resistance transfer from companion animals","volume":"72","author":"C Pomba","year":"2017","journal-title":"J. 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