{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:35:59Z","timestamp":1792874159389,"version":"4.5.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the study was to compare the effectiveness of neural mobilization technique with conservative treatment on pain intensity, cervical range of motion, and disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>It was a randomized clinical trial; data was collected from Mayo Hospital, Lahore. Eighty-eight patients fulfilling the sample selection criteria were randomly assigned into group 1 (neural mobilization) and group 2 (conventional treatment). Pain intensity was measured on a numeric pain rating scale, range of motion with an inclinometer, and functional status with neck disability index (NDI). Data were analyzed using SPSS, repeated measure ANOVA for cervical ranges and the Friedman test for NPRS and NDI were used for within-group analysis. Independent samples t-test for cervical ranges and Mann-Whitney U test for NPRS and NDI were used for between-group comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant improvement in pain, disability, and cervical range of motion after the treatment in both groups compared to the pre-treatment status (p &lt; 0.001), and when both groups were compared neural mobilization was more effective than conventional treatment in reducing pain and neck disability (p &lt; 0.001), but there was no significant difference present in the mean score of cervical range of motion between both groups. (p&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study concluded that both neural mobilization and conservative treatment were effective as an exercise program for patients with cervical radiculopathy, however, neural mobilization was more effective in reducing pain and neck disability in cervical radiculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ctri.nic.in\/Clinicaltrials\/login.php\/RCT20190325043109N1\" xlink:type=\"simple\">RCT20190325043109N1<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0278177","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T13:56:05Z","timestamp":1670334965000},"page":"e0278177","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of neural mobilization and conservative treatment on pain, range of motion, and disability in cervical radiculopathy: A randomized controlled trial"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-4140","authenticated-orcid":true,"given":"Shazia","family":"Rafiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamayun","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Amir","family":"Gillani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sharif","family":"Waqas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-5938","authenticated-orcid":true,"given":"Amna","family":"Zia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidrah","family":"Liaqat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir","family":"Rafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"issue":"1","key":"pone.0278177.ref001","first-page":"33","article-title":"Cervical radiculopathy: nonoperative management of neck pain and radicular symptoms","volume":"81","author":"JD Eubanks","year":"2010","journal-title":"Am Fam Physician"},{"issue":"3","key":"pone.0278177.ref002","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12178-016-9349-4","article-title":"Cervical radiculopathy","volume":"9","author":"S Iyer","year":"2016","journal-title":"Curr Rev Musculoskelet Med"},{"issue":"4","key":"pone.0278177.ref003","doi-asserted-by":"crossref","first-page":"e829","DOI":"10.1097\/PR9.0000000000000829","article-title":"Entrapment neuropathies: a contemporary approach to pathophysiology, clinical assessment, and management","volume":"5","author":"AB Schmid","year":"2020","journal-title":"Pain Rep"},{"issue":"2","key":"pone.0278177.ref004","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4184\/asj.2016.10.2.231","article-title":"Cervical Radiculopathy: Incidence and Treatment of 1,420 Consecutive Cases","volume":"10","author":"HJ Kim","year":"2016","journal-title":"Asian Spine J"},{"issue":"6","key":"pone.0278177.ref005","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.amepre.2008.02.013","article-title":"Worldwide variability in physical inactivity a 51-country survey","volume":"34","author":"R Guthold","year":"2008","journal-title":"Am J Prev Med"},{"key":"pone.0278177.ref006","first-page":"115","article-title":"Effectiveness of cervical traction combined with core muscle strengthening exercises in cervical radiculopathy","volume":"1","author":"U Muhammad","year":"2012","journal-title":"Journal Of Public Health and Biological Sciences"},{"issue":"1","key":"pone.0278177.ref007","first-page":"13","article-title":"Cervical radiculopathy: current diagnostic and treatment options","volume":"18","author":"RJ Nasca","year":"2009","journal-title":"J Surg Orthop Adv"},{"key":"pone.0278177.ref008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12998-016-0126-7","article-title":"Effectiveness of manual therapy for cervical radiculopathy, a review","volume":"24","author":"EJ Thoomes","year":"2016","journal-title":"Chiropr Man Therap"},{"issue":"2","key":"pone.0278177.ref009","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/PHM.0000000000001295","article-title":"Effects of Adding a Neurodynamic Mobilization to Motor Control Training in Patients With Lumbar Radiculopathy Due to Disc Herniation: A Randomized Clinical Trial.","volume":"99","author":"G Plaza-Manzano","year":"2020","journal-title":"Am J Phys Med Rehabil"},{"issue":"45","key":"pone.0278177.ref010","doi-asserted-by":"crossref","first-page":"e17733","DOI":"10.1097\/MD.0000000000017733","article-title":"The effect of exercise on cervical radiculopathy: A systematic review and meta-analysis","volume":"98","author":"L Liang","year":"2019","journal-title":"Medicine (Baltimore)."},{"issue":"2","key":"pone.0278177.ref011","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1142\/S1013702518500130","article-title":"Comparative effectiveness of transverse oscillatory pressure and cervical traction in the management of cervical radiculopathy: A randomized controlled study","volume":"38","author":"AO Ojoawo","year":"2018","journal-title":"Hong Kong Physiother J"},{"issue":"1","key":"pone.0278177.ref012","doi-asserted-by":"crossref","first-page":"65","DOI":"10.11124\/jbisrir-2015-1401","article-title":"The effectiveness of neural mobilizations in the treatment of musculoskeletal conditions: a systematic review protocol","volume":"13","author":"A Basson","year":"2015","journal-title":"JBI Database System Rev Implement Rep"},{"issue":"5","key":"pone.0278177.ref013","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3233\/BMR-140191","article-title":"The effects of neural mobilization on cervical radiculopathy patients\u2019 pain, disability, ROM, and deep flexor endurance","volume":"30","author":"DG Kim","year":"2017","journal-title":"J Back Musculoskelet Rehabil"},{"issue":"1","key":"pone.0278177.ref014","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1741-7015-8-18","article-title":"CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials","volume":"8","author":"KF Schulz","year":"2010","journal-title":"BMC Medicine"},{"issue":"2","key":"pone.0278177.ref015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"pone.0278177.ref016","author":"DS Butler","year":"2005","journal-title":"The neurodynamic techniques: a definitive guide from the Noigroup team: Noigroup publications"},{"issue":"12","key":"pone.0278177.ref017","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1080\/09593985.2018.1471763","article-title":"Reliability, construct validity, and responsiveness of the neck disability index and numeric pain rating scale in patients with mechanical neck pain without upper extremity symptoms","volume":"35","author":"D Young Ia Pt","year":"2019","journal-title":"Physiother Theory Pract"},{"issue":"7","key":"pone.0278177.ref018","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00586-008-0656-3","article-title":"Clinimetric evaluation of active range of motion measures in patients with non-specific neck pain: a systematic review","volume":"17","author":"CH de Koning","year":"2008","journal-title":"Eur Spine J"},{"issue":"10","key":"pone.0278177.ref019","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/PHM.0b013e3181ec98e6","article-title":"Reliability, construct validity, and responsiveness of the neck disability index, patient-specific functional scale, and numeric pain rating scale in patients with cervical radiculopathy","volume":"89","author":"IA Young","year":"2010","journal-title":"Am J Phys Med Rehabil"},{"issue":"3","key":"pone.0278177.ref020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11420-011-9218-z","article-title":"Cervical radiculopathy: a review","volume":"7","author":"JM Caridi","year":"2011","journal-title":"Hss j"},{"issue":"11","key":"pone.0278177.ref021","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18116176","article-title":"Manual Therapy in Cervical and Lumbar Radiculopathy: A Systematic Review of the Literature","volume":"18","author":"T Kuligowski","year":"2021","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"pone.0278177.ref022","first-page":"Cd010884","article-title":"Resistance exercise training for fibromyalgia","volume":"2013","author":"AJ Busch","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"16","key":"pone.0278177.ref023","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1097\/BRS.0000000000001645","article-title":"Motor Control Exercise for Nonspecific Low Back Pain: A Cochrane Review","volume":"41","author":"BT Saragiotto","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"issue":"9","key":"pone.0278177.ref024","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1589\/jpts.27.3011","article-title":"Exercise training for non-operative and post-operative patient with cervical radiculopathy: a literature review","volume":"27","author":"CH Cheng","year":"2015","journal-title":"J Phys Ther Sci"},{"issue":"12","key":"pone.0278177.ref025","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2519\/jospt.2005.35.12.802","article-title":"Manual physical therapy, cervical traction, and strengthening exercises in patients with cervical radiculopathy: a case series","volume":"35","author":"JA Cleland","year":"2005","journal-title":"J Orthop Sports Phys Ther"},{"issue":"9","key":"pone.0278177.ref026","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1007\/s00586-017-5121-8","article-title":"National clinical guidelines for non-surgical treatment of patients with recent onset neck pain or cervical radiculopathy","volume":"26","author":"P Kjaer","year":"2017","journal-title":"Eur Spine J"},{"issue":"3","key":"pone.0278177.ref027","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jphys.2018.05.003","article-title":"Exercise programs may be effective in preventing a new episode of neck pain: a systematic review and meta-analysis","volume":"64","author":"TF de Campos","year":"2018","journal-title":"J Physiother"},{"issue":"4","key":"pone.0278177.ref028","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0269215511419536","article-title":"The efficacy of forward head correction on nerve root function and pain in cervical spondylotic radiculopathy: a randomized trial","volume":"26","author":"AA Diab","year":"2012","journal-title":"Clin Rehabil"},{"issue":"31","key":"pone.0278177.ref029","doi-asserted-by":"crossref","first-page":"e7276","DOI":"10.1097\/MD.0000000000007276","article-title":"Shi-style cervical manipulations for cervical radiculopathy: A multicenter randomized-controlled clinical trial","volume":"96","author":"XJ Cui","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"pone.0278177.ref030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1179\/2042618611Y.0000000011","article-title":"Effectiveness of manual physical therapy in the treatment of cervical radiculopathy: a systematic review","volume":"19","author":"R Boyles","year":"2011","journal-title":"J Man Manip Ther."},{"issue":"6","key":"pone.0278177.ref031","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2519\/jospt.2009.2954","article-title":"Effects of upper extremity neural mobilization on thermal pain sensitivity: a sham-controlled study in asymptomatic participants","volume":"39","author":"JM Beneciuk","year":"2009","journal-title":"J Orthop Sports Phys Ther"},{"issue":"4","key":"pone.0278177.ref032","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.math.2015.02.001","article-title":"Identifying prognostic factors predicting outcome in patients with chronic neck pain after multimodal treatment: A retrospective study","volume":"20","author":"R De Pauw","year":"2015","journal-title":"Man Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0278177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T13:56:32Z","timestamp":1670334992000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0278177"}},"subtitle":[],"editor":[{"given":"Walid Kamal","family":"Abdelbasset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0278177","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,6]]}}}