{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:49:38Z","timestamp":1785008978067,"version":"3.55.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2016T042"],"award-info":[{"award-number":["2016T042"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>In young adults, overweight and hypertension possibly already trigger cardiac remodeling as seen in mature adults, potentially overlapping non-ischemic cardiomyopathy findings. To this end, in young overweight and hypertensive adults, we aimed to investigate changes in left ventricular mass (LVM) and cardiac volumes, and the impact of different body scales for indexation. We also aimed to explore the presence of myocardial fibrosis, fat and edema, and changes in cellular mass with extracellular volume (ECV), T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> tissue characteristics. We prospectively recruited 126 asymptomatic subjects (51% male) aged 27\u201341 years for 3T cardiac magnetic resonance imaging: 40 controls, 40 overweight, 17 hypertensive and 29 hypertensive overweight. Myocyte mass was calculated as (100%\u2013ECV) * height<jats:sup>2.7<\/jats:sup>-indexed LVM. Absolute LVM was significantly increased in overweight, hypertensive and hypertensive overweight groups (104 \u00b1 23, 109 \u00b1 27, 112 \u00b1 26 g) versus controls (87 \u00b1 21 g), with similar volumes. Body surface area (BSA) indexation resulted in LVM normalization in overweights (48 \u00b1 8 g\/m<jats:sup>2<\/jats:sup>) versus controls (47 \u00b1 9 g\/m<jats:sup>2<\/jats:sup>), but not in hypertensives (55 \u00b1 9 g\/m<jats:sup>2<\/jats:sup>) and hypertensive overweights (52 \u00b1 9 g\/m<jats:sup>2<\/jats:sup>). BSA-indexation overly decreased volumes in overweight versus normal-weight (LV end-diastolic volume; 80 \u00b1 14 versus 92 \u00b1 13 ml\/m<jats:sup>2<\/jats:sup>), where height<jats:sup>2.7<\/jats:sup>-indexation did not. All risk groups had lower ECV (23 \u00b1 2%, 23 \u00b1 2%, 23 \u00b1 3%) than controls (25 \u00b1 2%) (P = 0.006, P = 0.113, P = 0.039), indicating increased myocyte mass (16.9 \u00b1 2.7, 16.5 \u00b1 2.3, 18.1 \u00b1 3.5 versus 14.0 \u00b1 2.9 g\/m<jats:sup>2.7<\/jats:sup>). Native T<jats:sub>1<\/jats:sub> values were similar. Lower T<jats:sub>2<\/jats:sub> values in the hypertensive overweight group related to heart rate. In conclusion, BSA-indexation masks hypertrophy and causes volume overcorrection in overweight subjects compared to controls, height<jats:sup>2.7<\/jats:sup>-indexation therefore seems advisable.<\/jats:p>","DOI":"10.1371\/journal.pone.0278308","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T19:49:23Z","timestamp":1669924163000},"page":"e0278308","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-6098","authenticated-orcid":true,"given":"Gert J. H.","family":"Snel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riemer H. J. A.","family":"Slart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta K.","family":"Velthuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"van den Boomen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Sosnovik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent M.","family":"van Deursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi A. J. O.","family":"Dierckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J. H.","family":"Borra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niek H. J.","family":"Prakken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"issue":"5","key":"pone.0278308.ref001","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"M. 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