{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:37:31Z","timestamp":1782146251419,"version":"3.54.5"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>To increase the coverage of HPV vaccination, Malaysia implemented a national school-based vaccination program for all 13-year-old girls in 2010. Two years later, a clinic-based catch-up program was started for 16 to 21-year-old girls. We assessed the prevalence of a range of HPV genotypes, among a sample of urban women within the age groups of 18\u201324 and 35\u201345 years in 2019\u20132020, a decade into the national vaccination program. The HPV prevalence was then compared to that reported in an unvaccinated population in 2013\u20132015. We sampled a total of 1134 participants, comprising of 277 women aged 18\u201324 years and 857 women aged 35\u201345 years, from several urban clinics in the state of Selangor. Participants provided a self-acquired vaginal sample for HPV genotyping. Comprehensive sociodemographic and vaccination history were collected. The HPV vaccination coverage among women in the younger age group increased from 9.3% in 2013\u20132015 to 75.5% in 2019\u20132020. The prevalence of vaccine-targeted HPV16\/18 decreased 91% (CI: 14.5%\u201399.0%) among the younger women, from 4.0% in 2013\u20132015 to 0.4% in 2019\u20132020. There was also an 87% (CI: 27.5%\u201397.5%) reduction in HPV6\/11\/16\/18. There was no difference in the prevalence of non-vaccine targeted HPV genotypes among younger women. The HPV prevalence among older women, for both vaccine targeted and non-vaccine targeted genotypes in 2019\u20132020, did not differ from 2013\u20132015. The observed decline in prevalence of vaccine-targeted HPV genotype among younger women a decade after the national HPV vaccination program is an early indication of its effectiveness in reducing the burden of cervical cancer.<\/jats:p>","DOI":"10.1371\/journal.pone.0278477","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T18:30:35Z","timestamp":1671561035000},"page":"e0278477","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Changes in genital Human Papillomavirus (HPV) prevalence among urban females a decade after the Malaysian HPV vaccination program"],"prefix":"10.1371","volume":"17","author":[{"given":"Su Pei","family":"Khoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Adriana","family":"Muhammad Ridzuan Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Rajasuriar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazrila Hairizan","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patti","family":"Gravitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu Wan","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-1066","authenticated-orcid":true,"given":"Yin Ling","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"pone.0278477.ref001","unstructured":"Ferlay J. et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer.; 2020 [https:\/\/gco.iarc.fr\/today."},{"key":"pone.0278477.ref002","unstructured":"CDC. Cervical Cancer: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention; [updated 12 January 2021. https:\/\/www.cdc.gov\/cancer\/cervical\/basic_info\/index.htm."},{"issue":"11","key":"pone.0278477.ref003","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1470-2045(10)70230-8","article-title":"Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study","volume":"11","author":"S de Sanjose","year":"2010","journal-title":"Lancet Oncol"},{"issue":"7","key":"pone.0278477.ref004","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/ijc.24116","article-title":"Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis","volume":"124","author":"H De Vuyst","year":"2009","journal-title":"Int J Cancer"},{"key":"pone.0278477.ref005","unstructured":"World Health Organization. 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Key Findings Population and Housing Census of Malaysia 2020. WP Putrajaya; 2022."},{"key":"pone.0278477.ref014","unstructured":"ICO\/IARC HPV Information Centre. Human Papillomavirus and Related Diseases Report: MALAYSIA2019 May 14, 2021. https:\/\/hpvcentre.net\/statistics\/reports\/MYS.pdf."},{"key":"pone.0278477.ref015","unstructured":"The National Population and Family Development Board. 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WP Putrajaya Prime Minister\u2019s Department, 29 July 2022 2022."},{"key":"pone.0278477.ref038","unstructured":"Department of Statistics Malaysia. Social Statistics Bulletin Malaysia 2019 Putrajaya: Department of Statistics, Malaysia; 2019."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0278477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T18:30:53Z","timestamp":1671561053000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0278477"}},"subtitle":[],"editor":[{"given":"Hoh","family":"Boon-Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0278477","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]}}}