{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:21:36Z","timestamp":1771636896813,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Conflicting outcomes have been reported for the i-gel\u2122 and laryngeal mask airway (LMA) ProSeal\u2122 in children and adults during general anesthesia. Randomized controlled trials (RCTs) that yielded wide contrast outcomes between i-gel\u2122 and LMA ProSeal\u2122 were included in this meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Two authors independently identified RCTs that compared i-gel\u2122 with LMA ProSeal\u2122 among patients receiving general anesthesia by performing searches in EMBASE, Cochrane, PubMed, and ScienceDirect. Discussion was adopted to resolve disagreements. Data were counted with Review Manger 5.3 and pooled by applying weighted mean difference (MD) and rlsk ratio (RR), and related 95% confidence intervals.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 33 RCTs with 2605 patients were included in the meta-analysis. I-gel\u2122 provided a considerably lower oropharyngeal leak pressure [weighted average diversity (MD) = -1.53 (-2.89, -0.17), P = 0.03], incidence of blood staining on the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/supraglottic-airway-device\" xlink:type=\"simple\">supraglottic airway device<\/jats:ext-link>s [RR = 0.44, (0.28, 0.69), P = 0.0003], sore throat [RR = 0.31 (0.18, 0.52), P&lt;0.0001], and a short insertion time [MD = -5.61 (-7.71, -3.51), P&lt;0.00001] than LMA ProSeal\u2122. Compared with LMA ProSeal\u2122, i-gel\u2122 offered a significantly higher first-insertion success rate [RR = 1.03 (1.00, 1.06), P = 0.03] and ease of insertion [RR = 1.06 (1.01, 1.11), P = 0.03]. The gastric-tube-placement first insertion rate [RR = 1.04 (0.99, 1.10), P = 0.11], laryngospasm [RR = 0.76 (0.17, 3.31), P = 0.72], and cough [RR = 1.30 (0.49, 3.44), P = 0.60] between the two devices were similar.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Both devices could achieve a good seal to provide adequate ventilation. Compared with the used LMA ProSeal\u2122, the i-gel\u2122 was found to have fewer complications (blood stainning, sore throat) and offers certain advantages (short insertion time, higher first-insertion success rate and ease of insertion) in patients under general anesthesia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0278871","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T18:51:53Z","timestamp":1671130313000},"page":"e0278871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Contrast of oropharyngeal leak pressure and clinical performance of I-gel\u2122 and LMA ProSeal\u2122 in patients: A meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Yuan","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-3104","authenticated-orcid":true,"given":"Rurong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"issue":"5","key":"pone.0278871.ref001","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4103\/0019-5049.103959","article-title":"Paediatric airway management: What is new?","volume":"56","author":"S Ramesh","year":"2012","journal-title":"Indian J Anaesth."},{"key":"pone.0278871.ref002","first-page":"22","article-title":"Cardiovascular responses to tracheal extubation in normotensive patients; A 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Levitan","year":"2005","journal-title":"Anaesthesia"},{"issue":"5","key":"pone.0278871.ref006","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bja\/84.5.650","article-title":"The LMA \u2019ProSeal\u2019\u2014a laryngeal mask with an oesophageal vent.","volume":"84","author":"AI Brain","year":"2000","journal-title":"Br J Anaesth"},{"issue":"6","key":"pone.0278871.ref007","first-page":"1379","article-title":"Comparison of four methods for assessing airway sealing pressure with the laryngeal mask airway in adult patients.[J].","volume":"87","author":"C Keller","year":"1998","journal-title":"Anesthesia&Analgesia"},{"issue":"3","key":"pone.0278871.ref008","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1460-9592.2001.00649.x","article-title":"A comparison of four methods for assessing oropharyngeal leak pressure with the laryngeal mask airway (LMA) in paediatric patients.[J].","volume":"11","author":"M Lopez-Gil","year":"2001","journal-title":"Pediatric 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comparative evaluation of ProSeal laryngeal mask airway, I-gel and Supreme laryngeal mask airway in adult patients undergoing elective surgery: A randomised trial.","volume":"62","author":"A Singh","year":"2018","journal-title":"Indian J Anaesth"},{"issue":"4","key":"pone.0278871.ref030","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4103\/aer.AER_132_19","article-title":"Comparison of Two Supraglottic Airway Devices: I-gel Airway and ProSeal Laryngeal Mask Airway Following Digital Insertion in Nonparalyzed Anesthetized Patients.","volume":"13","author":"A Luthra","year":"2019","journal-title":"Anesth Essays Res."},{"issue":"1","key":"pone.0278871.ref031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00540-012-1477-4","article-title":"A randomized comparison of the i-gel\u2122 and the ProSeal laryngeal mask airway in pediatric patients: performance and fiberoptic findings.","volume":"27","author":"A Fukuhara","year":"2013","journal-title":"J Anesth."},{"issue":"10","key":"pone.0278871.ref032","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1399-6576.2012.02765.x","article-title":"LMA ProSeal(TM) vs. i-gel(TM) in ventilated children: a randomised, crossover study using the size 2 mask.","volume":"56","author":"L Gasteiger","year":"2012","journal-title":"Acta Anaesthesiol Scand."},{"issue":"2","key":"pone.0278871.ref033","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/0970-9185.130013","article-title":"Comparison of i-gel supraglottic airway and LMA-ProSeal\u2122 in pediatric patients under controlled ventilation.","volume":"30","author":"S Saran","year":"2014","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"5","key":"pone.0278871.ref034","doi-asserted-by":"crossref","first-page":"304","DOI":"10.5152\/TJAR.2015.49091","article-title":"Comparison of Four Different Supraglottic Airway Devices in Terms of Efficacy, Intra-ocular Pressure and Haemodynamic Parameters in Children Undergoing Ophthalmic Surgery.","volume":"43","author":"G Peker","year":"2015","journal-title":"Turk J Anaesthesiol Reanim"},{"issue":"2","key":"pone.0278871.ref035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/ija.IJA_594_17","article-title":"Comparison of the ProSeal laryngeal mask airway with the I-gel\u2122 in the different head-and-neck positions in anaesthetised paralysed children: A randomised controlled trial.","volume":"62","author":"G Banerjee","year":"2018","journal-title":"Indian J Anaesth."},{"issue":"2","key":"pone.0278871.ref036","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/0970-9185.130008","article-title":"Comparison of I-gel with proseal LMA in adult patients undergoing elective surgical procedures under general anesthesia without paralysis: A prospective randomized study.","volume":"30","author":"G Kini","year":"2014","journal-title":"J Anaesthesiol Clin 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