{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:16:37Z","timestamp":1784178997675,"version":"3.55.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>One of the major factors contributing to newborn morbidity and mortality across the globe is respiratory distress. In resource-constrained developing nations like Ethiopia, it is a significant issue. Depending on the quality of the care provided, the incidence and time to recovery may differ amongst medical facilities. However, Ethiopia still lacks appropriate data on the incidence and time to recovery from respiratory distress.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The aim of the study was to assess the incidence, time to recovery, and predictors among neonates admitted with respiratory distress in the neonatal intensive care unit at the University of Gondar Comprehensive Specialized Hospital.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>An institution-based retrospective follow-up study design was conducted among 452 neonates with respiratory distress. Data were collected using a data extraction checklist from the medical registry. The extracted data were entered into EPI INFO version 7.2.1.0 and then exported to STATA version 14 for analysis. The median time to recovery, the Kaplan Meier curve, and the log-rank test was computed. Both bi-variable and multivariable Cox regression models were applied to analyze the data. p-value \u2264 0.05 was considered statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of all respiratory distressed neonate,311 were recovered. The overall incidence rate of neonates admitted with from respiratory distress was 11.5 per 100-neonate day (95% CI: 10.30\u201312. 87) with 2,703-person day observation and the median time to recovery from respiratory distress was 7 days with (IQR = 3\u201313 days). Predictors of time to recovery from respiratory distress were very low birth weight (AHR = 0.17, 95% CI: 0.08\u20130.41), low birth weight (AHR = 0.50, 95% CI: 0.31\u20130.81), very preterm (AHR = 0.42,95% CI:0.20\u20130.89), sepsis (AHR = 0.50 95% CI: 0.38\u20130.65), hypothermia (AHR = 0.61, 95% CI: 0.39\u20130.81), and Apgar scores less than seven at first (AHR = 0.35, 95% CI: 0.15\u20130.79) and fifth minute (AHR = 0.45, 95% CI: 0.20\u20130.97).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The incidence and time to recovery in this study were discreetly acceptable as compared to previous study. The aforementioned predictors could be used to identify neonates with respiratory distress who are at risk of developing a long-term illness and guide prompt referral to hospitals. This will also provide clinicians with prognostic information, as longer recovery times have economic and social implications in resource limited countries like Ethiopia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0278887","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T18:41:00Z","timestamp":1671129660000},"page":"e0278887","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Incidence, time to recovery and predictors among neonates admitted with respiratory distress to the neonatal intensive care unit at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2021"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-6992","authenticated-orcid":true,"given":"Engidaw Fentahun","family":"Enyew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desalegn Anmut","family":"Bitew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abebaw Addis","family":"Gelagay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"pone.0278887.ref001","author":"D.S.M. Kue","year":"2020","journal-title":"Respiratory distress in Full and Post term neonates: Prevalence, Etiologies and Outcomes in a Tertiary Health Center in Yaound\u00e9"},{"key":"pone.0278887.ref002","author":"S. Sivanandan","year":"2017","journal-title":"Respiratory distress in term neonates in low-resource settings. in Seminars in Fetal and Neonatal Medicine."},{"issue":"4","key":"pone.0278887.ref003","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1542\/peds.2013-1131","article-title":"Late preterm infants: near term but still in a critical developmental time period","volume":"132","author":"A. Kugelman","year":"2013","journal-title":"Pediatrics"},{"issue":"1","key":"pone.0278887.ref004","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/jp.2008.216","article-title":"The need for neonatal glucose-6-phosphate dehydrogenase screening: a global perspective.","volume":"29","author":"M. Kaplan","year":"2009","journal-title":"Journal of Perinatology"},{"issue":"1","key":"pone.0278887.ref005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.prrv.2012.02.002","article-title":"Respiratory distress of the term newborn infant.","volume":"14","author":"M.O. Edwards","year":"2013","journal-title":"Paediatric respiratory reviews"},{"issue":"1","key":"pone.0278887.ref006","article-title":"Risk Factors of Respiratory Diseases Among Neonates in Neonatal Intensive Care Unit of Qena University Hospital, Egypt","volume":"86","author":"K.A.A. Baseer","year":"2020","journal-title":"Annals of global health"},{"issue":"2","key":"pone.0278887.ref007","first-page":"453","article-title":"Neonatal respiratory distress: a practical approach to its diagnosis and management","volume":"62","author":"A.K. Pramanik","year":"2015","journal-title":"Pediatric Clinics"},{"issue":"9","key":"pone.0278887.ref008","first-page":"643","article-title":"Neonatal respiratory distress in early neonatal period and its outcome.","volume":"6","author":"K. Swarnkar","year":"2015","journal-title":"Int J Biomed Adv Res"},{"issue":"7","key":"pone.0278887.ref009","first-page":"987","article-title":"Respiratory distress in the newborn","volume":"76","author":"C.L. Hermansen","year":"2007","journal-title":"American family physician"},{"issue":"3","key":"pone.0278887.ref010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcmd.2008.12.005","article-title":"The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis","volume":"42","author":"E.T. Nkhoma","year":"2009","journal-title":"Blood Cells, Molecules, and Diseases"},{"issue":"1","key":"pone.0278887.ref011","first-page":"1","article-title":"Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study.","volume":"18","author":"N.E. Assefa","year":"2018","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0278887.ref012","article-title":"Neonatal respiratory distress in a reference neonatal unit in Cameroon: an analysis of prevalence, predictors, etiologies and outcomes","volume":"24","author":"J.N. Tochie","year":"2016","journal-title":"Pan African Medical Journal"},{"issue":"2","key":"pone.0278887.ref013","doi-asserted-by":"crossref","first-page":"257","DOI":"10.12816\/0043086","article-title":"Prevalence of respiratory distress syndrome in neonates","volume":"70","author":"S.A. Qari","year":"2018","journal-title":"The Egyptian journal of hospital medicine"},{"issue":"1","key":"pone.0278887.ref014","doi-asserted-by":"crossref","first-page":"76","DOI":"10.18203\/2349-3291.ijcp20160092","article-title":"Predictors of poor outcome in neonates with respiratory distress.","volume":"3","author":"V. Sathenahalli","year":"2016","journal-title":"Int J Contemp Pediatr"},{"issue":"7","key":"pone.0278887.ref015","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s12098-012-0914-6","article-title":"Respiratory distress including meconium aspiration syndrome in vigorous neonates born through meconium stained amniotic fluid: incidence, onset, severity and predictors at birth","volume":"80","author":"S. Singh","year":"2013","journal-title":"The Indian Journal of Pediatrics"},{"issue":"1","key":"pone.0278887.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-019-2227-5","article-title":"Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study.","volume":"19","author":"T.T. Orsido","year":"2019","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0278887.ref017","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1057\/s41271-016-0002-7","article-title":"Transforming our world: implementing the 2030 agenda through sustainable development goal indicators","volume":"37","author":"B.X. Lee","year":"2016","journal-title":"Journal of public health policy"},{"issue":"1","key":"pone.0278887.ref018","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis","volume":"7","author":"S. Chawanpaiboon","year":"2019","journal-title":"The Lancet Global Health"},{"issue":"1","key":"pone.0278887.ref019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-016-3979-8","article-title":"Cause of neonatal deaths in Northern Ethiopia: a prospective cohort study.","volume":"17","author":"H.G. Mengesha","year":"2017","journal-title":"BMC public health"},{"key":"pone.0278887.ref020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2307\/2531021","article-title":"Sample-size formula for the proportional-hazards regression model","author":"D.A. Schoenfeld","year":"1983","journal-title":"Biometrics"},{"issue":"7","key":"pone.0278887.ref021","doi-asserted-by":"crossref","first-page":"e0235544","DOI":"10.1371\/journal.pone.0235544","article-title":"Incidence of respiratory distress and its predictors among neonates admitted to the neonatal intensive care unit, Black Lion Specialized Hospital, Addis Ababa, Ethiopia.","volume":"15","author":"Y.A. Aynalem","year":"2020","journal-title":"PloS one"},{"issue":"3","key":"pone.0278887.ref022","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5455\/medarh.2019.73.183-186","article-title":"Incidence, risk factors and outcome of respiratory distress syndrome in term infants at academic Centre, Jeddah, Saudi Arabia.","volume":"73","author":"T.W. Alfarwati","year":"2019","journal-title":"Medical Archives"},{"key":"pone.0278887.ref023","volume":"2020","author":"T. Derese","year":"2019","journal-title":"The Median Survival Recovery Time and Associated Factors Among Admitted Neonate in Intensive Care Units of Dire Dawa Public HospitalsEast Ethiopia"},{"key":"pone.0278887.ref024","author":"D.E. Ballot","year":"2016","journal-title":"Factors associated with survival to discharge of newborns in a middle-income country, in Epidemiology of Communicable and Non-Communicable Diseases-Attributes of Lifestyle and Nature on Humankind"},{"issue":"1","key":"pone.0278887.ref025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2393-12-1","article-title":"Poor birth weight recovery among low birth weight\/preterm infants following hospital discharge in Kampala, Uganda","volume":"12","author":"F.B. Namiiro","year":"2012","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0278887.ref026","first-page":"12","article-title":"Neonatal respiratory distress syndrome: tackling a worldwide problem.","volume":"44","author":"J. Dyer","year":"2019","journal-title":"Pharmacy and Therapeutics"},{"issue":"1","key":"pone.0278887.ref027","first-page":"1","article-title":"Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study","volume":"20","author":"Y. Yu","year":"2020","journal-title":"BMC pediatrics"},{"issue":"1","key":"pone.0278887.ref028","first-page":"48","article-title":"Hypothermia at Birth and its Associated Com-plications in Newborn infants: a Follow up Study","volume":"35","author":"F. Nayeri","year":"2006","journal-title":"Iranian Journal of Public Health"},{"issue":"12","key":"pone.0278887.ref029","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/apa.13998","article-title":"Hypothermia at neonatal intensive care unit admission was not associated with respiratory disease or death in very preterm infants","volume":"106","author":"C. Jensen","year":"2017","journal-title":"Acta Paediatrica"},{"issue":"2","key":"pone.0278887.ref030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3126\/jngmc.v14i2.21527","article-title":"Evaluation of Hypothermia in Sick Neonates as Predictor of Fatality at a Tertiary Care Center of Eastern Nepal","volume":"14","author":"P. Kanodia","year":"2016","journal-title":"Journal of Nepalgunj Medical College"},{"issue":"7","key":"pone.0278887.ref031","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1056\/NEJM200102153440701","article-title":"The continuing value of the Apgar score for the assessment of newborn infants","volume":"344","author":"B.M. Casey","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"pone.0278887.ref032","first-page":"1","article-title":"Apgar score and neonatal mortality in China: an observational study from a national surveillance system.","volume":"21","author":"Y. 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