{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:49:14Z","timestamp":1779230954916,"version":"3.51.4"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To assess the effectiveness of Triclosan coated suture in reducing surgical site infections (SSIs) rate after caesarian delivery (CD).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Study design<\/jats:title>\n<jats:p>Three hundred eighty patients were randomly assigned to closure with polyglactin non coated suture VICRYL, or with polyglactin coated suture VICRYL Plus after caesarian section. The primary outcome was the rate of SSIs within 30 days after surgery and secondary outcomes were the rate of wound healing complications.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>SSI rate was 2.5% in Triclosan group compared to 8.1% with non-coated suture. Use of Triclosan coated suture (TCS) was associated with 69% reduction in SSI rate (p = 0.037; ORa:0.294; 95% CI:0.094\u20130.921). The use of Triclosan coated suture was associated with statistically lower risk of wound oedema (2.5% vs 10%), (p = 0.019; OR:0.595), dehiscence (3.8% vs 10.6%), (p = 0.023; OR:0.316) and hematoma (p = 0.035; OR:0.423).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our results confirm the effectiveness of Triclosan coated suture in reducing SSI rate and wound healing disturbances.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>Registered at ClinicalTrials.gov \/ ID (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05330650\" xlink:type=\"simple\">NCT05330650<\/jats:ext-link>).<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0278939","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T18:44:30Z","timestamp":1671129870000},"page":"e0278939","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Triclosan coated suture in obstetrical surgery: A prospective randomized controlled study (NCT05330650)"],"prefix":"10.1371","volume":"17","author":[{"given":"Wael","family":"Mbarki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8207-7874","authenticated-orcid":true,"given":"Hajer","family":"Bettaieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrine","family":"Souayeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idriss","family":"Laabidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadhemi","family":"Rouis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumaya","family":"Halouani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Boufarghine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Bouyahia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahma","family":"Bouhmida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariem","family":"Ouederni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anissa","family":"Ben Amor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Chermiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadir","family":"Laamiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Lika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Chaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedhili","family":"Oueslati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najeh","family":"Hsayaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaouki","family":"Mbarki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"issue":"9","key":"pone.0278939.ref001","doi-asserted-by":"crossref","first-page":"e029727","DOI":"10.1136\/bmjopen-2019-029727","article-title":"The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature","volume":"9","author":"I Ahmed","year":"2019","journal-title":"BMJ Open"},{"key":"pone.0278939.ref002","unstructured":"Global Guidelines for the Prevention of Surgical Site Infection [Internet]. Geneva: World Health Organization; 2018 [cited 2021 Dec 9]. (WHO Guidelines Approved by the Guidelines Review Committee). Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK536404\/."},{"issue":"3","key":"pone.0278939.ref003","doi-asserted-by":"crossref","first-page":"100154","DOI":"10.1016\/j.infpip.2021.100154","article-title":"Evaluation of the effect of triclosan coated sutures in the prevention of surgical site infections in a Spanish hospital setting: A prospective, observational study.","volume":"3","author":"M Bustamante Montalvo","year":"2021","journal-title":"Infect Prev Pract."},{"issue":"1","key":"pone.0278939.ref004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jamcollsurg.2016.10.029","article-title":"American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update.","volume":"224","author":"KA Ban","year":"2017","journal-title":"J Am Coll Surg"},{"issue":"3","key":"pone.0278939.ref005","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1089\/sur.2014.005","article-title":"Multi-Center Randomized Controlled Trial on the Effect of Triclosan-Coated Sutures on Surgical Site Infection after Colorectal Surgery.","volume":"16","author":"I Mattavelli","year":"2015","journal-title":"Surg Infect"},{"issue":"2","key":"pone.0278939.ref006","article-title":"In vivo antibacterial efficacy of MONOCRYL plus antibacterial suture (Poliglecaprone 25 with triclosan)","volume":"8","year":"2007","journal-title":"Surg Infect"},{"key":"pone.0278939.ref007","article-title":"Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee\u2014PubMed [Internet]","author":"Guideline for Prevention of Surgical Site Infection","year":"1999"},{"issue":"12","key":"pone.0278939.ref008","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1007\/s00134-018-5113-0","article-title":"ECDC definitions and methods for the surveillance of healthcare-associated infections in intensive care units","volume":"44","author":"D Plachouras","year":"2018","journal-title":"Intensive Care 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Rasi\u0107","year":"2011","journal-title":"Coll Antropol"},{"issue":"5","key":"pone.0278939.ref012","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1089\/sur.2014.072","article-title":"Association between Triclosan-Coated Sutures for Abdominal Wall Closure and Incisional Surgical Site Infection after Open Surgery in Patients Presenting with Fecal Peritonitis: A Randomized Clinical Trial.","volume":"16","author":"J Ruiz-Tovar","year":"2015","journal-title":"Surg Infect"},{"issue":"4","key":"pone.0278939.ref013","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/bjs.9062","article-title":"Systematic review and meta-analysis of triclosan-coated sutures for the prevention of surgical-site infection.","volume":"100","author":"ZX Wang","year":"2013","journal-title":"Br J Surg."},{"issue":"2","key":"pone.0278939.ref014","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1002\/bjs.10443","article-title":"Meta-analysis of the potential economic impact following introduction of absorbable antimicrobial sutures.","volume":"104","author":"DJ Leaper","year":"2017","journal-title":"Br J Surg."},{"issue":"5","key":"pone.0278939.ref015","first-page":"588","article-title":"Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial.","volume":"34","author":"PS Santos","year":"2019","journal-title":"Braz J Cardiovasc Surg."},{"issue":"1","key":"pone.0278939.ref016","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1473-3099(16)30373-5","article-title":"Triclosan-containing sutures versus ordinary sutures for reducing surgical site infections in children: a double-blind, randomised controlled trial","volume":"17","author":"M Renko","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"pone.0278939.ref017","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00384-018-3138-z","article-title":"Effect of triclosan-coated sutures on surgical site infections in pilonidal disease: prospective randomized study.","volume":"33","author":"NC Arslan","year":"2018","journal-title":"Int J Colorectal Dis."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0278939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T18:44:45Z","timestamp":1671129885000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0278939"}},"subtitle":[],"editor":[{"given":"Antonio 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