{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:31:24Z","timestamp":1790699484365,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This systematic review aims to examine the influencing factors of undergraduates\u2019 depressive symptoms by summarizing the categories and intensity of the factors, to lay a foundation for subsequent research.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Two authors independently searched in Medline (Ovid), Embase (Ovid), Scopu, PsycINFO, PsycARTICLES, the Chinese Scientific Journal Database (VIP Database), China National Knowledge database (CNKI), and the WanFang database for cohort studies related to the influencing factors affecting depressive symptoms among undergraduates published prior to September 12, 2022. Adjusted Newcastle-Ottawa scale (NOS) was used to assess the risk of bias. Meta-analyses of regression coefficient estimates were performed to calculate pooled estimates with R 4.0.3 software.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 73 cohort studies were included, involving 46362 participants from 11 countries. Factors affecting depressive symptoms were classified into relational, psychological, predictors of response to trauma, occupational, sociodemographic and lifestyle factors. In Meta-analysis, 4 of 7 influencing factors were revealed to be statistically significant: negative coping (B = 0.98, 95%CI: 0.22\u20131.74), rumination (B = 0.06, 95%CI: 0.01\u20130.11), stress (OR = 0.22, 95%CI: 0.16\u20130.28) and childhood abuse (B = 0.42, 95%CI:0.13\u20130.71). No significant association was found in positive coping, gender and ethnicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Limitations<\/jats:title>\n<jats:p>The current studies have the problems of inconsistent use of scales and large heterogeneity of research design, making it difficult to summarize, which is expected to be further improved in future research.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This review evidences the importance of several influencing factors of depressive symptoms among undergraduates. We advocate for more high-quality studies with more coherent and appropriate study designs and outcome measurement approaches in this field.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p><jats:bold><jats:italic>Systematic review registration<\/jats:italic>:<\/jats:bold> PROSPERO registration <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42021267841\" xlink:type=\"simple\">CRD42021267841<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279050","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T18:30:36Z","timestamp":1677781836000},"page":"e0279050","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Influencing factors of depressive symptoms among undergraduates: A 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systematic review and meta-analysis.","volume":"96","author":"YH Wang","year":"2017","journal-title":"Medicine (Baltimore)."},{"key":"pone.0279050.ref005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cpr.2017.04.010","article-title":"Upward counterfactual thinking and depression: A meta-analysis.","volume":"55","author":"AG Broomhall","year":"2017","journal-title":"Clin Psychol Rev"},{"issue":"3","key":"pone.0279050.ref006","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jpsychires.2012.11.015","article-title":"A systematic review of studies of depression prevalence in university students","volume":"47","author":"AK Ibrahim","year":"2013","journal-title":"J Psychiatr Res"},{"issue":"21","key":"pone.0279050.ref007","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1001\/jama.2016.17324","article-title":"Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis","volume":"316","author":"LS Rotenstein","year":"2016","journal-title":"JAMA"},{"issue":"4","key":"pone.0279050.ref008","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/medu.13770","article-title":"Prevalence of depressive symptoms among medical students: overview of systematic reviews.","volume":"53","author":"W Tam","year":"2019","journal-title":"Med Educ."},{"issue":"4","key":"pone.0279050.ref009","doi-asserted-by":"crossref","first-page":"e0153454","DOI":"10.1371\/journal.pone.0153454","article-title":"Prevalence of Depression among Chinese University Students: A Meta-Analysis.","volume":"11","author":"XY Lei","year":"2016","journal-title":"PLoS One"},{"key":"pone.0279050.ref010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nedt.2018.01.009","article-title":"Prevalence of depression among nursing students: A systematic review and meta-analysis.","volume":"63","author":"YJ Tung","year":"2018","journal-title":"Nurse Educ 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Reilly","year":"2012","journal-title":"Cogn Emot."},{"issue":"1","key":"pone.0279050.ref017","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jbtep.2010.09.003","article-title":"Resilience to depressive symptoms: The buffering effects of enhancing cognitive style and positive life events.","volume":"42","author":"GJ Haeffel","year":"2011","journal-title":"J Behav Ther Exp Psychiatry"},{"key":"pone.0279050.ref018","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ijop.12248","article-title":"Demographic factors, childhood maltreatment and psychological functioning among university students\u2019 in Ghana: A retrospective study.","volume":"521","author":"S Adjorlolo","year":"2017","journal-title":"Int J Psychol"},{"issue":"6","key":"pone.0279050.ref019","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/07448481.2019.1705837","article-title":"Relationship of childhood maltreatment, exercise, and emotion regulation to self-esteem, PTSD, and 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Sakamoto","year":"2000","journal-title":"J Psychol"},{"issue":"1","key":"pone.0279050.ref021","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1521\/ijct_2016_09_19","article-title":"Rumination: Reflection Can Amplify the Depressogenic Effects of Brooding","volume":"10","author":"MB Junkins","year":"2017","journal-title":"Int J Cogn Ther"},{"key":"pone.0279050.ref022","first-page":"i4086","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation.","volume":"354","author":"D Moher","year":"2016","journal-title":"BMJ"},{"issue":"4","key":"pone.0279050.ref023","doi-asserted-by":"crossref","first-page":"80","DOI":"10.13105\/wjma.v5.i4.80","article-title":"Assessing the quality of studies in meta-analyses: advantages and limitations of the Newcastle Ottawa Scale","volume":"5","author":"C Luchini","year":"2017","journal-title":"World Journal of Meta-Analysis"},{"key":"pone.0279050.ref024","article-title":"The Newcastle\u2012Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses.","author":"G. Wells","year":"2017"},{"issue":"3","key":"pone.0279050.ref025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/0004867416642844","article-title":"Developing a broad categorisation scheme to describe risk factors for mental illness, for use in prevention policy and planning.","volume":"51","author":"G Furber","year":"2017","journal-title":"Aust N Z J Psychiatry"},{"issue":"2","key":"pone.0279050.ref026","doi-asserted-by":"crossref","first-page":"e0211882","DOI":"10.1371\/journal.pone.0211882","article-title":"Linking childhood emotional abuse and depressive symptoms: The role of emotion dysregulation and interpersonal problems.","volume":"14","author":"C Christ","year":"2019","journal-title":"PLoS One."},{"issue":"5","key":"pone.0279050.ref027","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s10902-020-00308-7","article-title":"How Adverse Childhood Experiences Relate to Subjective Wellbeing in College Students: The Role of Resilience and Depression.","volume":"22","author":"MO Kelifa","year":"2021","journal-title":"J Happiness Stud."},{"issue":"1","key":"pone.0279050.ref028","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1037\/pspp0000038","article-title":"Refining the vulnerability model of low self-esteem and depression: Disentangling the effects of genuine self-esteem and narcissism.","volume":"110","author":"U Orth","year":"2016","journal-title":"J Pers Soc Psychol"},{"issue":"1","key":"pone.0279050.ref029","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/oem.60.1.3","article-title":"Reducing work related psychological ill health and sickness absence: a systematic literature review.","volume":"60","author":"S Michie","year":"2003","journal-title":"Occup Environ Med"},{"issue":"6","key":"pone.0279050.ref030","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1521\/jscp.2014.33.6.560","article-title":"A Closer Look at Self-Esteem, Perceived Social Support, and Coping Strategy: A Prospective Study of Depressive Symptomatology across the Transition To College.","volume":"33","author":"C Lee","year":"2014","journal-title":"J Soc Clin Psychol."},{"issue":"1","key":"pone.0279050.ref031","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1037\/tra0000172","article-title":"University student voices on healing and recovery following tragedy.","volume":"10","author":"ED Felix","year":"2018","journal-title":"Psychol Trauma"},{"issue":"3","key":"pone.0279050.ref032","first-page":"410","article-title":"Social Self-Efficacy Predicts Chinese College Students\u2019 First-Year Transition: A Four-Wave Longitudinal Investigation","volume":"23","author":"M. Hui","year":"2014","journal-title":"Journal of Career Assessment"},{"issue":"1754","key":"pone.0279050.ref033","article-title":"The integrated motivational-volitional model of suicidal behaviour","volume":"373","author":"RC O\u2019Connor","year":"2018","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"1","key":"pone.0279050.ref034","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1037\/1528-3542.1.1.25","article-title":"Rumination as a common mechanism relating depressive risk factors to depression.","volume":"1","author":"J Spasojevic","year":"2001","journal-title":"Emotion"},{"issue":"5","key":"pone.0279050.ref035","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1023\/A:1018769531641","article-title":"Neuroticism and ruminative response style as predictors of change in depressive symptomatology.","volume":"22","author":"SA Nolan","year":"1998","journal-title":"Cognitive Ther Res"},{"key":"pone.0279050.ref036","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1196\/annals.1351.006","article-title":"Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases","volume":"1069","author":"E Calcagni","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"pone.0279050.ref037","first-page":"1435","article-title":"Relationship between depressive symptoms and negative life events of university students.","volume":"47","author":"Lan MA","year":"2020","journal-title":"Modern Preventive Medicine"},{"issue":"4","key":"pone.0279050.ref038","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1521\/jscp.2016.35.4.342","article-title":"The Role of Family Support and Perceived Stress Reactivity in Predicting Depression in College Freshman.","volume":"35","author":"SM Levens","year":"2016","journal-title":"J Soc Clin Psychol."},{"issue":"1","key":"pone.0279050.ref039","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/15298868.2012.736690","article-title":"Positive Personality Features and Stress among First-year University Students: Implications for Psychological Distress, Functional Impairment, and Self-esteem.","volume":"13","author":"A Besser","year":"2014","journal-title":"Self Identity."},{"key":"pone.0279050.ref040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1348\/135910709X457423","article-title":"Gender and self-reported mental health problems: Predictors of help seeking from a general practitioner","volume":"15","author":"D. Tedstone Doherty","year":"2010","journal-title":"Br. J. 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