{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:00:37Z","timestamp":1768316437128,"version":"3.49.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17015018"],"award-info":[{"award-number":["17015018"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["221S0001"],"award-info":[{"award-number":["221S0001"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06277 [CoBiA]"],"award-info":[{"award-number":["16H06277 [CoBiA]"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene\u2013environment interactions, has been attracting attention in recent years. However, evidence for gene\u2013environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene\u2013lifestyle interactions in practice could aid in optimizing interventions according to genetic risk.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study aimed to elucidate the effects of gene\u2013lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg\/m<jats:sup>2<\/jats:sup> and -0.07 (0.16), respectively. The correlation between GRS and BMI was <jats:italic>r<\/jats:italic>(12,916) = 0.13 (95% confidence interval [CI] 0.11\u20130.15, <jats:italic>P<\/jats:italic> &lt; 0.001). An interaction between GRS and saturated fatty acid intake was observed (\u03b2 = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and <jats:italic>n<\/jats:italic>-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (\u03b2 = -0.12, 95% CI -0.22 to -0.03).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene\u2013lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279169","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T18:26:44Z","timestamp":1675880804000},"page":"e0279169","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of gene\u2013lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-9477","authenticated-orcid":true,"given":"Sho","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Narimatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Ikezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-9538","authenticated-orcid":true,"given":"Chisato","family":"Shimanoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineko","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Hishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-1147","authenticated-orcid":true,"given":"Isao","family":"Oze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko N.","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Kusakabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Takezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisaku","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Otani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagato","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyonori","family":"Kuriki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokichi","family":"Arisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakurako","family":"Katsuura-Kamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakatochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihide","family":"Momozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Wakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"pone.0279169.ref001","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"GBD 2015 Obesity Collaborators","year":"2017","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"pone.0279169.ref002","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1016\/j.jada.2005.02.045","article-title":"Obesity and the built environment","volume":"105","author":"KM Booth","year":"2005","journal-title":"J Am Diet Assoc"},{"key":"pone.0279169.ref003","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/bmj.315.7106.477","article-title":"An \u201cecological\u201d approach to the obesity pandemic","volume":"315","author":"G Egger","year":"1997","journal-title":"BMJ"},{"key":"pone.0279169.ref004","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-8587(17)30200-0","article-title":"Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications","volume":"6","author":"MO Goodarzi","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"pone.0279169.ref005","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1042\/CS20160221","article-title":"The importance of gene-environment interactions in human obesity","volume":"130","author":"H Reddon","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"pone.0279169.ref006","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13073-020-00742-5","article-title":"Polygenic risk scores: from research tools to clinical instruments","volume":"12","author":"CM Lewis","year":"2020","journal-title":"Genome Med"},{"key":"pone.0279169.ref007","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa1203039","article-title":"Sugar-sweetened beverages and genetic risk of obesity","volume":"367","author":"Q Qi","year":"2012","journal-title":"N Engl J Med"},{"key":"pone.0279169.ref008","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/jhg.2015.148","article-title":"Gene-environment interactions in obesity: implication for future applications in preventive medicine","volume":"61","author":"S Nakamura","year":"2016","journal-title":"J Hum Genet"},{"key":"pone.0279169.ref009","first-page":"559","article-title":"Gene-obesogenic environment interactions in the UK Biobank study","volume":"46","author":"J Tyrrell","year":"2017","journal-title":"Int J Epidemiol"},{"key":"pone.0279169.ref010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12916-017-0862-0","article-title":"Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies","volume":"15","author":"T Wang","year":"2017","journal-title":"BMC Med"},{"key":"pone.0279169.ref011","doi-asserted-by":"crossref","first-page":"E787","DOI":"10.3390\/ijms18040787","article-title":"Gene-diet interaction and precision nutrition in obesity","volume":"18","author":"Y Heianza","year":"2017","journal-title":"Int J Mol Sci"},{"key":"pone.0279169.ref012","first-page":"12","article-title":"Guide and position of the International Society of nutrigenetics\/nutrigenomics on personalised nutrition: Part 1 \u2013Fields of precision nutrition","volume":"9","author":"LR Ferguson","year":"2016","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"pone.0279169.ref013","first-page":"317","article-title":"The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) to detect gene-environment interactions for cancer","volume":"8","author":"J-MICC Study Group","year":"2007","journal-title":"Asian Pac J Cancer Prev"},{"key":"pone.0279169.ref014","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2188\/jea.JE20200147","article-title":"Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study","volume":"31","author":"K Takeuchi","year":"2021","journal-title":"J Epidemiol"},{"key":"pone.0279169.ref015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"CC Chang","year":"2015","journal-title":"GigaScience"},{"key":"pone.0279169.ref016","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"pone.0279169.ref017","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"key":"pone.0279169.ref018","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"key":"pone.0279169.ref019","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2008.08.019","article-title":"Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies","volume":"83","author":"Y Yamaguchi-Kabata","year":"2008","journal-title":"Am J Hum Genet"},{"key":"pone.0279169.ref020","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000488946","article-title":"Genome-wide association study of renal function traits: results from the Japan multi-institutional collaborative cohort study","volume":"47","author":"A Hishida","year":"2018","journal-title":"Am J Nephrol"},{"key":"pone.0279169.ref021","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nmeth.2307","article-title":"Improved whole-chromosome phasing for disease and population genetic studies","volume":"10","author":"O Delaneau","year":"2013","journal-title":"Nat Methods"},{"key":"pone.0279169.ref022","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"S Das","year":"2016","journal-title":"Nat Genet"},{"key":"pone.0279169.ref023","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/ng.3951","article-title":"Genome-wide association study identifies 112 new loci for body mass index in the Japanese population","volume":"49","author":"M Akiyama","year":"2017","journal-title":"Nat Genet"},{"key":"pone.0279169.ref024","first-page":"40","article-title":"Development of a data-based short food frequency questionnaire for assessing nutrient intake by middle-aged Japanese","volume":"5","author":"S Tokudome","year":"2004","journal-title":"Asian Pac J Cancer Prev"},{"key":"pone.0279169.ref025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2188\/jea.15.135","article-title":"Relative validity of a short food frequency questionnaire for assessing nutrient intake versus three-day weighed diet records in middle-aged Japanese","volume":"15","author":"Y Tokudome","year":"2005","journal-title":"J Epidemiol"},{"key":"pone.0279169.ref026","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2188\/jea.17.100","article-title":"Reproducibility of a short food frequency questionnaire for Japanese general population","volume":"17","author":"N Imaeda","year":"2007","journal-title":"J Epidemiol"},{"key":"pone.0279169.ref027","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s12020-019-01926-9","article-title":"Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population","volume":"64","author":"H Uemura","year":"2019","journal-title":"Endocrine"},{"key":"pone.0279169.ref028","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"CL Craig","year":"2003","journal-title":"Med Sci Sports Exerc"},{"key":"pone.0279169.ref029","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/. 2020."},{"key":"pone.0279169.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"D Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"pone.0279169.ref031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"A Kuznetsova","year":"2017","journal-title":"J Stat Softw"},{"key":"pone.0279169.ref032","volume-title":"An R Companion to Applied Regression","author":"J FaS Weisberg","year":"2019","edition":"3"},{"key":"pone.0279169.ref033","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ijo.2010.187","article-title":"Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction","volume":"35","author":"D Corella","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"pone.0279169.ref034","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.jand.2014.03.014","article-title":"Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations","volume":"114","author":"P Casas-Agustench","year":"2014","journal-title":"J Acad Nutr Diet"},{"issue":"Suppl 3","key":"pone.0279169.ref035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161365.GL","article-title":"American Association of Clinical Endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity","volume":"22","author":"WT Garvey","year":"2016","journal-title":"Endocr Pract"},{"key":"pone.0279169.ref036","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.jacc.2013.11.004","article-title":"2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Obesity Society","volume":"63","author":"MD Jensen","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"pone.0279169.ref037","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41588-018-0183-z","article-title":"Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations","volume":"50","author":"AV Khera","year":"2018","journal-title":"Nat Genet"},{"key":"pone.0279169.ref038","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41588-019-0379-x","article-title":"Clinical use of current polygenic risk scores may exacerbate health disparities","volume":"51","author":"AR Martin","year":"2019","journal-title":"Nat Genet"},{"key":"pone.0279169.ref039","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mce.2014.11.029","article-title":"The sexual dimorphism of obesity","volume":"402","author":"BF Palmer","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"pone.0279169.ref040","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1177\/1359105317714318","article-title":"People with a body mass index \u2a7e30 under-report their dietary intake: A systematic review","volume":"24","author":"H Wehling","year":"2019","journal-title":"J Health Psychol"},{"key":"pone.0279169.ref041","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3177\/jnsv.58.253","article-title":"Characteristics of under- and over-reporters of energy intake among young Japanese women","volume":"58","author":"Freshmen in Dietetic Courses Study II Group","year":"2012","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"pone.0279169.ref042","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1017\/S0007114515002706","article-title":"Prevalence and characteristics of misreporting of energy intake in US adults: NHANES 2003\u20132012","volume":"114","author":"K Murakami","year":"2015","journal-title":"Br J Nutr"},{"key":"pone.0279169.ref043","first-page":"441","article-title":"Prevalence and characteristics of misreporting of energy intake in Japanese adults: the 2012 National Health and Nutrition Survey","volume":"27","author":"K Murakami","year":"2018","journal-title":"Asia Pac J Clin Nutr"},{"key":"pone.0279169.ref044","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2016.8729","article-title":"Association of a genetic risk score with body mass index across different birth cohorts","volume":"316","author":"S Walter","year":"2016","journal-title":"JAMA"},{"key":"pone.0279169.ref045","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12263-014-0416-4","article-title":"Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity","volume":"9","author":"K Tanisawa","year":"2014","journal-title":"Genes Nutr"},{"key":"pone.0279169.ref046","doi-asserted-by":"crossref","first-page":"e1005378","DOI":"10.1371\/journal.pgen.1005378","article-title":"The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study","volume":"11","author":"TW Winkler","year":"2015","journal-title":"PLOS Genet"},{"key":"pone.0279169.ref047","doi-asserted-by":"crossref","unstructured":"OECD. OECD reviews of public health: Japan: A healthier tomorrow. OECD Reviews of Public. Health, OECD Publishing, Paris. 2019; doi: 10.1787\/9789264311602-en","DOI":"10.1787\/9789264311602-en"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T18:27:43Z","timestamp":1675880863000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279169"}},"subtitle":[],"editor":[{"given":"Tomoyoshi","family":"Komiyama","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0279169","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,8]]}}}