{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:50:12Z","timestamp":1744113012023,"version":"3.37.3"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alberta Health, Alberta, Canada"},{"name":"Canadian Breast Cancer Foundation, Prairies\/NWT Chapter, Canada"},{"name":"Alberta Cancer Foundation, Alberta, Canada"},{"name":"Canadian Partnership Against Cancer and Health Canada, Ontario, Canada"},{"name":"Alberta Health Services, Alberta, Canada"},{"DOI":"10.13039\/100013373","name":"Alberta Machine Intelligence Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>We propose a method to predict when a woman will develop breast cancer (BCa) from her lifestyle and health history features. To address this objective, we use data from the Alberta\u2019s Tomorrow Project of 18,288 women to train Individual Survival Distribution (ISD) models to predict an individual\u2019s Breast-Cancer-Onset (BCaO) probability curve. We show that our three-step approach\u2013(1) filling missing data with multiple imputations by chained equations, followed by (2) feature selection with the multivariate Cox method, and finally, (3) using MTLR to learn an ISD model\u2013produced the model with the smallest L1-Hinge loss among all calibrated models with comparable C-index. We also identified 7 actionable lifestyle features that a woman can modify and illustrate how this model can predict the quantitative effects of those changes\u2013suggesting how much each will potentially extend her BCa-free time. We anticipate this approach could be used to identify appropriate interventions for individuals with a higher likelihood of developing BCa in their lifetime.<\/jats:p>","DOI":"10.1371\/journal.pone.0279174","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T18:28:34Z","timestamp":1671474514000},"page":"e0279174","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Personalized breast cancer onset prediction from lifestyle and health history information"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-5501","authenticated-orcid":true,"given":"Shi-ang","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaykumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sambasivarao","family":"Damaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Shen-Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"pone.0279174.ref001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"pone.0279174.ref002","article-title":"Cancer statistics for the year 2020: An overview","author":"J Ferlay","year":"2021","journal-title":"Int J Cancer"},{"key":"pone.0279174.ref003","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021","volume":"71","author":"RL Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"pone.0279174.ref004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"RL Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"pone.0279174.ref005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gendis.2018.05.001","article-title":"Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis","volume":"5","author":"Y Feng","year":"2018","journal-title":"Genes Dis"},{"key":"pone.0279174.ref006","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.7150\/ijbs.21635","article-title":"Risk Factors and Preventions of Breast Cancer","volume":"13","author":"Y-S Sun","year":"2017","journal-title":"Int J Biol Sci"},{"key":"pone.0279174.ref007","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa021293","article-title":"Puberty and genetic susceptibility to breast cancer in a case-control study in twins","volume":"348","author":"AS Hamilton","year":"2003","journal-title":"N Engl J Med"},{"key":"pone.0279174.ref008","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","article-title":"Cancer is a preventable disease that requires major lifestyle changes","volume":"25","author":"P Anand","year":"2008","journal-title":"Pharm Res"},{"key":"pone.0279174.ref009","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/metabo12020154","article-title":"the Multi-Omics View of Cancer","volume":"12","author":"Wishart D. 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