{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:05:59Z","timestamp":1772215559959,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    An epidemic not attributable to plague caused thousands of deaths in Milan in the summer of 1629, a time of war and famine that immediately preceded the even more fatal Great Plague of 1630 that killed an estimated ten of thousands of people. The 5,993 deaths of 1629 recorded in the\n                    <jats:italic>Liber Mortuorum<\/jats:italic>\n                    of Milan (a city with an estimated population of 130,000 inhabitants at the time) were 45.7% more than the average number recorded between 1601 and 1628. Registered deaths peaked in July, and 3,363 of the deaths (56,1%) were attributed to a febrile illness which, in most cases (2,964, 88%), was not associated with a rash or organ involvement. These deaths involved 1,627 males and 1,334 females and occurred at a median age of 40 years (range 0\u201395). In this paper, we discuss the possible cause of the epidemic, which may have been an outbreak of typhoid fever.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0279218","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T13:31:11Z","timestamp":1686231071000},"page":"e0279218","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Milan\u2019s forgotten epidemic of summer 1629, a few months before the last great plague: An investigation into the possible cause"],"prefix":"10.1371","volume":"18","author":[{"given":"Massimo","family":"Galli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Oreni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-6219","authenticated-orcid":true,"given":"Anna Lisa","family":"Ridolfo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Formenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Luconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Boracchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spinello","family":"Antinori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"Biganzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-0168","authenticated-orcid":true,"given":"Folco","family":"Vaglienti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"pone.0279218.ref001","volume-title":"La guerra per la successione di Mantova e del Monferrato (1628\u20131631)","author":"Romolo Quazza","year":"1926"},{"key":"pone.0279218.ref002","volume-title":"Malatesta, Milan, 1641","author":"G. Ripamonti","year":"1841"},{"key":"pone.0279218.ref003","unstructured":"Tadino A. Raguaglio dell\u2019origine et giornali sucessi della gran peste contagiosa, venefica, et malefica seguita nella citt\u00e0 di Milano, et suo ducato dall\u2019anno 1629 fino all\u2019anno 1632. Bidelli, Milan, 1648. pages 8\u201311"},{"key":"pone.0279218.ref004","unstructured":"Borromeo F. De pestilentia quae Mediolani anno 1630 magnam stragem edidit. Rusconi, Milan, 1987 (Italian translation), pages 45\u201347."},{"key":"pone.0279218.ref005","first-page":"59","volume-title":"Annali delle epidemie occorse in Italia dalle prime memorie fino al 1850","author":"A. Corradi","year":"1865"},{"key":"pone.0279218.ref006","volume-title":"Cant\u00f9 C: Scorsa d\u2019un lombardo negli archivj di Venezia","author":"PA Marioni","year":"1856"},{"key":"pone.0279218.ref007","first-page":"224","volume-title":"Aspetti della vita italo-spagnola nel Cinque e Seicento","author":"F. Nicolini","year":"1934"},{"key":"pone.0279218.ref008","volume-title":"Processo agli untori. Milano 1630cronaca e atti giudiziari","author":"E. Paccagnini","year":"1988"},{"issue":"30","key":"pone.0279218.ref009","first-page":"262","article-title":"Il Magistrato di sanit\u00e0 nello stato di Lombardia","volume":"15","author":"A. Visconti","year":"1911","journal-title":"Archivio Storico Lombardo"},{"key":"pone.0279218.ref010","unstructured":"Bendiscioli M. Politica, amministrazione e religione nell\u2019et\u00e0 dei Borromei. In Storia di Milano, Fondazione Treccani degli Alfieri, Milan 1957. Vol. X, Photostatic copy of Senatore Settala\u2019s autograph inserted on page 348."},{"key":"pone.0279218.ref011","volume-title":"Storia arcana ed aneddotica d\u2019Italia","author":"PA Marioni","year":"1855"},{"key":"pone.0279218.ref012","first-page":"25","volume-title":"La popolazione di Milano dal Rinascimento","author":"F. Vaglienti","year":"2013"},{"key":"pone.0279218.ref013","unstructured":"Archivio di Stato di Milano (ASMi), Atti di Governo, Popolazione PA, B. 117, 1629."},{"key":"pone.0279218.ref014","unstructured":"Ferrario G. Statistica medica di Milano. Dal secolo XV fino ai nostri giorni. Guglielmini and Redaelli, Milan, 1840, page 375."},{"key":"pone.0279218.ref015","volume-title":"De febribus Libri IV","author":"D. Sennert","year":"1628","edition":"2"},{"key":"pone.0279218.ref016","first-page":"282","volume-title":"De differentiis febrium","author":"Claudius Galenus"},{"key":"pone.0279218.ref017","volume-title":"Libri quinque","author":"L. Settala","year":"1622"},{"key":"pone.0279218.ref018","author":"M. Vanti","year":"1944"},{"key":"pone.0279218.ref019","first-page":"139","volume-title":"L\u2019Italia del lungo cinquecento (1494\u20131629)","author":"G. Alfani","year":"2010"},{"key":"pone.0279218.ref020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0891-5520(03)00093-X","article-title":"The history of epidemic typhus","volume":"18","author":"D Raoult","year":"2004","journal-title":"Infect Dis Clin North Am"},{"key":"pone.0279218.ref021","first-page":"31","volume-title":"Epidemie e strutture sanitarie nell\u2019Italia del Rinascimento","author":"CM Cipolla","year":"1986"},{"key":"pone.0279218.ref022","first-page":"166","volume-title":"Little, Brown & Comp","author":"H. Zinsser","year":"1934"},{"key":"pone.0279218.ref023","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1473-3099(08)70150-6","article-title":"Epidemic typhus","volume":"8","author":"Y Bechah","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"pone.0279218.ref024","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0140-6736(05)67181-4","article-title":"Typhoid and paratyphoid fever","volume":"366","author":"MK Bhan","year":"2005","journal-title":"Lancet"},{"key":"pone.0279218.ref025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1473-3099(18)30685-6","article-title":"The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"GBD 2017 Typhoid and Paratyphoid Collaborators","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"pone.0279218.ref026","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tim.2014.06.007","article-title":"Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence","volume":"22","author":"JS Gunn","year":"2014","journal-title":"Trends Microbiol"},{"key":"pone.0279218.ref027","first-page":"129","article-title":"De semitertiana libri quatuor","author":"A. van den Spiegel","year":"1624","journal-title":"Apud haeredes J Theodori de Bry"},{"key":"pone.0279218.ref028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13293-018-0187-5","article-title":"Sexual dimorphism in bacterial infections","volume":"9","author":"ER V\u00e1zquez-Mart\u00ednez","year":"2018","journal-title":"Biol Sex Differ"},{"key":"pone.0279218.ref029","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/CEG.S36569","article-title":"A plausible explanation for male dominance in typhoid ileal perforation.","volume":"5","author":"M. Khan","year":"2012","journal-title":"Clin Exp Gastroenterol"},{"key":"pone.0279218.ref030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/archinte.1946.00220060002001","article-title":"Typhoid; clinical analysis of 360 cases","volume":"78","author":"BM Stuart","year":"1946","journal-title":"Arch Intern Med (Chic)"},{"key":"pone.0279218.ref031","doi-asserted-by":"crossref","first-page":"020407","DOI":"10.7189\/jogh.05.020407","article-title":"Systematic review of the global epidemiology, clinical and laboratory profile of enteric fever","volume":"5","author":"A Azmatullah","year":"2015","journal-title":"J Glob Health"},{"key":"pone.0279218.ref032","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/clinids\/13.1.85","article-title":"Patterns of morbidity and mortality in typhoid fever dependent on age and gender: review of 552 hospitalized patients with diarrhea","volume":"13","author":"T Butler","year":"1991","journal-title":"Rev Infect Dis"},{"key":"pone.0279218.ref033","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1056\/NEJM198401123100203","article-title":"Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone","volume":"310","author":"SL Hoffman","year":"1984","journal-title":"N Engl J Med"},{"key":"pone.0279218.ref034","volume-title":"Aspetti dell\u2019urbanistica di Milano medievale.","author":"G. Soldi Rondinini","year":"1992"},{"key":"pone.0279218.ref035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0035-9203(91)90180-7","article-title":"Hydrocortisone in chloramphenicol-treated severe typhoid fever in Papua New Guinea","volume":"85","author":"SJ Rogerson","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pone.0279218.ref036","volume-title":"Venezia, Apud Danielem Zanettum","author":"V. Alsario Della Croce","year":"1603"},{"key":"pone.0279218.ref037","unstructured":"Sella, D. La popolazione di Milano nei secoli XVI e XVII. In: Storia di Milano, Fondazione Treccani degli Alfieri, Milan 1957. 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