{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:19:59Z","timestamp":1773771599986,"version":"3.50.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To assess the repeatability of flow signal voids (FSV) measurements of the choriocapillaris (CC) and choroid (CH) in central serous chorioretinopathy (CSCR) by Swept-Source optical coherence tomography angiography (SS-OCTA).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Cross-sectional study including 104 eyes of 52 patients with unilateral CSCR. Two consecutive macular 6x6 mm SS-OCTA scans (Plex Elite 9000; Zeiss, Dublin, CA) were obtained from the affected eyes with persistent subretinal fluid (SRF) (CSCR group) and the fellow unaffected eyes (control group). FSV area and the number of contours measurements were analyzed using three slabs: inner CC, outer CC and CH. The repeatability of the measurements was assessed with intraclass correlation coefficients (ICC) and coefficients of variation (CV).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In the CSCR group, ICCs for the FSV area in the three slabs were all \u22650.859, observing higher values for the outer CC and the CH (0.959 and 0.964) than for the inner CC (0.859). Similar ICC values were obtained for the FSV area in control eyes, observing the highest values for the outer CC (0.949), followed by the CH (0.932) and inner CC (0.844). Regarding the FSV number of contours measurements, ICCs were higher for the outer CC and CH (0.949 and 0.932) than for inner CC (0.844). CV for the FSV area was 4.7%, 3.8% and 8.6% in the CSCR eyes and 4.8%, 3.9% and 9.3% in the control group for the inner CC, outer CC and CH respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>SS-OCTA offers good repeatability to quantify macular FSV in CSCR eyes and fellow eyes<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279243","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T18:29:04Z","timestamp":1671215344000},"page":"e0279243","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Repeatability of choriocapillaris flow voids by optical coherence tomography angiography in central serous chorioretinopathy"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-3464","authenticated-orcid":true,"given":"Jos\u00e9 Ignacio","family":"Fern\u00e1ndez-Vigo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7748-0506","authenticated-orcid":true,"given":"Francisco Javier","family":"Moreno-Morillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"L\u00f3pez-Varela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Novo-Bujan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Ortega-Hortas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Burgos-Blasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-2555","authenticated-orcid":true,"given":"Lorenzo","family":"L\u00f3pez-Guajardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-6736","authenticated-orcid":true,"given":"Juan","family":"Donate-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"pone.0279243.ref001","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.oret.2020.07.026","article-title":"Multimodal Imaging-Based Central Serous Chorioretinopathy Classification","volume":"4","author":"J Chhablani","year":"2020","journal-title":"Ophthalmol Retin"},{"key":"pone.0279243.ref002","doi-asserted-by":"crossref","first-page":"100865","DOI":"10.1016\/j.preteyeres.2020.100865","article-title":"Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities","volume":"79","author":"R Kaye","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"pone.0279243.ref003","first-page":"905","article-title":"Choriocapillaris Flow Features Follow a Power Law Distribution: Implications for Characterization and Mechanisms of Disease Progression","volume":"257","author":"RF Spaide","year":"2019","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"pone.0279243.ref004","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.05.003","article-title":"Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis","volume":"48","author":"A Daruich","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"pone.0279243.ref005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41433-018-0158-4","article-title":"Pachychoroid disease","volume":"33","author":"CMG Cheung","year":"2019","journal-title":"Eye"},{"key":"pone.0279243.ref006","first-page":"1","article-title":"Analysis of choriocapillaris perfusion and choroidal layer changes in patients with chronic central serous chorioretinopathy randomised to micropulse laser or photodynamic therapy","author":"M Ho","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"pone.0279243.ref007","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1136\/bjophthalmol-2019-315482","article-title":"OCTA characterisation of microvascular retinal alterations in patients with central serous chorioretinopathy","volume":"104","author":"M Battista","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"pone.0279243.ref008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ajo.2018.07.004","article-title":"Optical Coherence Tomography Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy","volume":"194","author":"C Rochepeau","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"pone.0279243.ref009","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1167\/iovs.15-17140","article-title":"Oct angiography compared to fluorescein and indocyanine green angiography in chronic central serous chorioretinopathy","volume":"56","author":"MM Teussink","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"pone.0279243.ref010","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/IAE.0000000000002040","article-title":"CHRONIC CENTRAL SEROUS CHORIORETINOPATHY: Early and Late Morphological and Functional Changes After Verteporfin Photodynamic Therapy","volume":"39","author":"P Iacono","year":"2019","journal-title":"Retina"},{"key":"pone.0279243.ref011","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000456676","article-title":"Effect of photodynamic therapy on optical coherence tomography angiography in eyes with chronic central serous chorioretinopathy","volume":"237","author":"Y Xu","year":"2017","journal-title":"Ophthalmologica"},{"key":"pone.0279243.ref012","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1097\/IAE.0000000000002271","article-title":"Patterns of Choriocapillaris Flow Signal Voids in Central Serous Chorioretinopathy","volume":"39","author":"A Matet","year":"2019","journal-title":"Retina"},{"key":"pone.0279243.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"RF Spaide","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"pone.0279243.ref014","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2018.07.002","article-title":"OCT angiography and evaluation of the choroid and choroidal vascular disorders","volume":"67","author":"E Borrelli","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"pone.0279243.ref015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ajo.2020.08.045","article-title":"Guidelines for Imaging the Choriocapillaris Using OCT Angiography","volume":"222","author":"Z Chu","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"pone.0279243.ref016","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajo.2020.05.027","article-title":"Optimizing the Repeatability of Choriocapillaris Flow Deficit Measurement From Optical Coherence Tomography Angiography","volume":"219","author":"I Byon","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"pone.0279243.ref017","first-page":"48","article-title":"Normative database and determinants of macular vessel density measured by optical coherence tomography angiography","author":"JI Fern\u00e1ndez-Vigo","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"key":"pone.0279243.ref018","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41433-020-01217-y","article-title":"Evaluation of the inner choroid using OCT angiography","volume":"35","author":"F Corvi","year":"2021","journal-title":"Eye (Lond)"},{"key":"pone.0279243.ref019","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ajo.2019.09.017","article-title":"Correlations Between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes Using Swept Source OCT Angiography","volume":"209","author":"Y Shi","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"pone.0279243.ref020","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/bjophthalmol-2016-308764","article-title":"Repeatability of automated vessel density measurements using optical coherence tomography angiography","volume":"101","author":"M Al-Sheikh","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"pone.0279243.ref021","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/IAE.0000000000001407","article-title":"REPRODUCIBILITY of VESSEL DENSITY MEASUREMENT with OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY in EYES with and WITHOUT RETINOPATHY","volume":"37","author":"Q You","year":"2017","journal-title":"Retina"},{"key":"pone.0279243.ref022","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00417-020-04716-6","article-title":"Repeatability and reproducibility of vessel density measurements on optical coherence tomography angiography in diabetic retinopathy","volume":"258","author":"ES Levine","year":"2020","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"pone.0279243.ref023","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1177\/1120672119834472","article-title":"Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography","volume":"30","author":"JI Fern\u00e1ndez-Vigo","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"pone.0279243.ref024","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1167\/iovs.17-22953","article-title":"A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography.","volume":"59","author":"Q Zhang","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"pone.0279243.ref025","first-page":"1","article-title":"Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy","volume":"15","author":"HS Yang","year":"2020","journal-title":"PLoS One"},{"key":"pone.0279243.ref026","first-page":"122","article-title":"The OpenCV Library. Dr. Dobb\u2019s.","volume":"120","author":"G. Bradski","year":"2000","journal-title":"J Softw Tools"},{"key":"pone.0279243.ref027","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ajo.2016.07.023","article-title":"Choriocapillaris Flow Features Follow a Power Law Distribution: Implications for Characterization and Mechanisms of Disease Progression","volume":"170","author":"RF Spaide","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"pone.0279243.ref028","first-page":"1","article-title":"Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study","volume":"10","author":"E Lin","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0279243.ref029","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10792-019-01182-w","article-title":"Features of the choriocapillaris on four different optical coherence tomography angiography devices","volume":"40","author":"C Yun","year":"2020","journal-title":"Int Ophthalmol."},{"key":"pone.0279243.ref030","first-page":"1","article-title":"Artifact-free evaluation of choriocapillaris perfusion in central serous chorioretinopathy.","volume":"5","author":"MA Burnasheva","year":"2021","journal-title":"Vis"},{"key":"pone.0279243.ref031","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s10792-020-01376-7","article-title":"Swept-source optical coherence tomography angiography alleviates shadowing artifacts caused by subretinal fluid","volume":"40","author":"M Reich","year":"2020","journal-title":"Int Ophthalmol"},{"key":"pone.0279243.ref032","first-page":"11206721211027060","article-title":"Early vessel occlusion and recanalization after photodynamic therapy in central serous chorioretinopathy by OCT angiography","author":"JI Fern\u00e1ndez-Vigo","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"pone.0279243.ref033","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/bjophthalmol-2016-309441","article-title":"Interchangeability and reliability of macular perfusion parameter measurements using optical coherence tomography angiography","volume":"101","author":"J Dong","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"pone.0279243.ref034","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/bjophthalmol-2017-310700","article-title":"Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography","volume":"102","author":"BJ Fenner","year":"2018","journal-title":"Br J Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T18:29:38Z","timestamp":1671215378000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279243"}},"subtitle":[],"editor":[{"given":"Michele","family":"Madigan","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0279243","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]}}}