{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:19:27Z","timestamp":1793747967120,"version":"4.6.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["3U2GGH000372"],"award-info":[{"award-number":["3U2GGH000372"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HD083343"],"award-info":[{"award-number":["R01HD083343"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Research Foundation, South Africa","award":["Research Career Advancement Fellowship"],"award-info":[{"award-number":["Research Career Advancement Fellowship"]}]},{"name":"South African Department of Science and Innovation and the National Research Foundation\u2019s Centre of Excellence in HIV Prevention","award":["Grant 96354"],"award-info":[{"award-number":["Grant 96354"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In sub-Saharan Africa, high HIV incidence rates in adolescent girls and young women (AGYW) persist despite extensive HIV prevention efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort of 2,710 HIV-negative AGYW (15\u201324 years) in KwaZulu-Natal, South Africa were interviewed at baseline and followed-up approximately 18 months later (2014\u20132017). Associations between HIV seroconversion and socio-demographic and behavioural variables measured at baseline and follow-up were examined using Cox regression and a proximate determinants framework. Inter-relationships between determinants were measured using logistic regression. Separate models were built for 15\u201319 and 20-24-year-olds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Weighted HIV incidence was 3.92 per 100 person-years (95% confidence interval: 3.27\u20134.69; 163 seroconversions over 4,016 person-years). Among 15-19-year-olds, absence of family support (adjusted hazards ratio (aHR): 3.82 (1.89\u20137.72)), having a circumcised partner (aHR: 0.5 (0.27\u20130.94)) or one who was HIV-positive and not on antiretroviral therapy (ART) (aHR: 6.21 (2.56\u201315.06)) were associated with HIV incidence. Those reporting an absence of family support were also more likely to report &gt;1 partner during follow-up (odds ratio (OR): 2.7(1.11\u20136.57)). Among 20-24-year-olds, failure to complete secondary school (aHR: 1.89 (1.11\u20133.21)), inconsistent condom use (aHR: 3.01 (1.14\u20137.96)) and reporting partner(s) who were HIV-positive and not on ART (aHR: 7.75 (3.06\u201319.66)) were associated with HIV incidence. Failure to complete secondary school among 20-24-year-olds was associated with inconsistent condom use (OR: 1.82 (1.20\u20132.77)) and reporting an HIV-positive partner not on ART (OR: 3.53(1.59\u20137.82)) or an uncircumcised partner (OR: 1.39 (1.08\u20131.82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Absence of family support and incomplete schooling are associated with risky sexual behaviours and HIV acquisition in AGYW. In addition, partner-level prevention\u2014condom use, medical circumcision, and viral suppression\u2013continue to play an important role in reducing HIV risk in AGYW. These findings support the use of combination HIV prevention programs that consider structural as well as biological and behavioural HIV risk factors in their design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0279289","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T13:24:35Z","timestamp":1671629075000},"page":"e0279289","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["HIV incidence and associated risk factors in adolescent girls and young women in South Africa: A population-based cohort study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-2086","authenticated-orcid":true,"given":"Lara","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha B. M.","family":"Kharsany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilton","family":"Humphries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Maughan-Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaymarlin","family":"Govender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie","family":"Cawood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Khanyile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"pone.0279289.ref001","unstructured":"UNAIDS. End inequalities. End AIDS. Global AIDS Strategy 2021\u20132026. 2021."},{"key":"pone.0279289.ref002","unstructured":"UNAIDS. Global HIV & AIDS statistics\u2014Fact sheet 2021 [cited 12 September 2022]. https:\/\/www.unaids.org\/en\/resources\/fact-sheet."},{"key":"pone.0279289.ref003","unstructured":"Simbayi L, Zuma K, Zungu N, Moyo S, Marinda E, Jooste S, et al. South African national HIV prevalence, incidence, behaviour and communication survey, 2017: towards achieving the UNAIDS 90-90-90 targets. 2019."},{"issue":"11","key":"pone.0279289.ref004","doi-asserted-by":"crossref","first-page":"e1521","DOI":"10.1016\/S2214-109X(19)30410-3","article-title":"Recent levels and trends in HIV incidence rates among adolescent girls and young women in ten high-prevalence African countries: a systematic review and meta-analysis","volume":"7","author":"I Birdthistle","year":"2019","journal-title":"The Lancet Global Health"},{"issue":"11","key":"pone.0279289.ref005","doi-asserted-by":"crossref","first-page":"e1914378","DOI":"10.1001\/jamanetworkopen.2019.14378","article-title":"Trends in HIV Prevention, Treatment, and Incidence in a Hyperendemic Area of KwaZulu-Natal, South Africa","volume":"2","author":"ABM Kharsany","year":"2019","journal-title":"JAMA Netw 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Acquir Immune Defic Syndr"},{"issue":"8","key":"pone.0279289.ref012","doi-asserted-by":"crossref","first-page":"e0159162","DOI":"10.1371\/journal.pone.0159162","article-title":"Sexual behaviour of men and women within age-disparate partnerships in South Africa: implications for young women\u2019s HIV risk","volume":"11","author":"B Maughan-Brown","year":"2016","journal-title":"PloS one"},{"issue":"6","key":"pone.0279289.ref013","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s13224-011-0107-7","article-title":"Contraceptive methods: needs, options and utilization","volume":"61","author":"R Jain","year":"2011","journal-title":"J Obstet Gynaecol India"},{"issue":"Suppl 1","key":"pone.0279289.ref014","first-page":"74","article-title":"Genital immunology and HIV susceptibility in young women","volume":"69","author":"TJ Yi","year":"2013","journal-title":"Am J Reprod Immunol"},{"issue":"4","key":"pone.0279289.ref015","first-page":"104","article-title":"HIV and sexually transmitted diseases: lethal synergy","volume":"12","author":"MS Cohen","year":"2004","journal-title":"Top HIV Med"},{"key":"pone.0279289.ref016","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijid.2020.06.046","article-title":"Population prevalence of sexually transmitted infections in a high HIV burden district in KwaZulu-Natal, South Africa: Implications for HIV epidemic control","volume":"98","author":"ABM Kharsany","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"5","key":"pone.0279289.ref017","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1097\/QAI.0000000000001544","article-title":"Effect of Schooling on Age-Disparate Relationships and Number of Sexual Partners Among Young Women in Rural South Africa Enrolled in HPTN 068","volume":"76","author":"MCD Stoner","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"15","key":"pone.0279289.ref018","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1097\/QAD.0000000000001584","article-title":"The effect of school attendance and school dropout on incident HIV and HSV-2 among young women in rural South Africa enrolled in HPTN 068","volume":"31","author":"MCD Stoner","year":"2017","journal-title":"AIDS"},{"issue":"6","key":"pone.0279289.ref019","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/ije\/dyn131","article-title":"Keep them in school: the importance of education as a protective factor against HIV infection among young South African women","volume":"37","author":"AE Pettifor","year":"2008","journal-title":"Int J Epidemiol"},{"issue":"2","key":"pone.0279289.ref020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/jech.2006.053827","article-title":"The association between school attendance, HIV infection and sexual behaviour among young people in rural South Africa","volume":"62","author":"JR Hargreaves","year":"2008","journal-title":"J Epidemiol Community Health"},{"issue":"3","key":"pone.0279289.ref021","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/QAD.0b013e3282f2aac3","article-title":"Systematic review exploring time trends in the association between educational attainment and risk of HIV infection in sub-Saharan Africa","volume":"22","author":"JR Hargreaves","year":"2008","journal-title":"AIDS"},{"issue":"1","key":"pone.0279289.ref022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1758-2652-14-25","article-title":"HIV infection and sexual risk behaviour among youth who have experienced orphanhood: systematic review and meta-analysis","volume":"14","author":"D Operario","year":"2011","journal-title":"Journal of the International AIDS Society"},{"issue":"7","key":"pone.0279289.ref023","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s10461-010-9693-0","article-title":"Food insecurity and sexual risk in an HIV endemic community in Uganda","volume":"15","author":"CL Miller","year":"2011","journal-title":"AIDS Behav"},{"issue":"9734","key":"pone.0279289.ref024","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(10)60548-X","article-title":"Intimate partner violence, relationship power inequity, and incidence of HIV infection in young women in South Africa: a cohort study","volume":"376","author":"RK Jewkes","year":"2010","journal-title":"Lancet"},{"issue":"Supplement_1","key":"pone.0279289.ref025","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1086\/425282","article-title":"Integrating demographic and epidemiological approaches to research on HIV\/AIDS: the proximate-determinants framework","volume":"191","author":"JT Boerma","year":"2005","journal-title":"The Journal of infectious diseases"},{"key":"pone.0279289.ref026","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1186\/s12889-015-2179-2","article-title":"Strengthening HIV surveillance in the antiretroviral therapy era: rationale and design of a longitudinal study to monitor HIV prevalence and incidence in the uMgungundlovu District, KwaZulu-Natal, South Africa","volume":"15","author":"AB Kharsany","year":"2015","journal-title":"BMC Public Health"},{"issue":"10","key":"pone.0279289.ref027","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1097\/QAD.0000000000001506","article-title":"Age-disparate relationships and HIV incidence in adolescent girls and young women: evidence from Zimbabwe","volume":"31","author":"R Schaefer","year":"2017","journal-title":"AIDS"},{"issue":"1","key":"pone.0279289.ref028","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/ije\/dym255","article-title":"HIV incidence in 3 years of follow-up of a Zimbabwe cohort\u20141998-2000 to 2001\u201303: contributions of proximate and underlying determinants to transmission","volume":"37","author":"B Lopman","year":"2008","journal-title":"Int J Epidemiol"},{"issue":"3","key":"pone.0279289.ref029","doi-asserted-by":"crossref","first-page":"e001389","DOI":"10.1136\/bmjgh-2019-001389","article-title":"Does voluntary medical male circumcision protect against sexually transmitted infections among men and women in real-world scale-up settings? Findings of a household survey in KwaZulu-Natal, South Africa","volume":"4","author":"S Davis","year":"2019","journal-title":"BMJ Glob Health"},{"key":"pone.0279289.ref030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ssmph.2016.12.004","article-title":"The health benefits of secondary education in adolescents and young adults: an international analysis in 186 low-, middle-and high-income countries from 1990 to 2013","volume":"3","author":"RM Viner","year":"2017","journal-title":"SSM-population health"},{"issue":"2","key":"pone.0279289.ref031","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1009571518900","article-title":"The role of families in adolescent HIV prevention: a review","volume":"3","author":"T Perrino","year":"2000","journal-title":"Clin Child Fam Psychol Rev"},{"key":"pone.0279289.ref032","doi-asserted-by":"crossref","first-page":"S389","DOI":"10.1097\/QAD.0000000000000340","article-title":"Cash plus care: social protection cumulatively mitigates HIV-risk behaviour among adolescents in South Africa","volume":"28","author":"LD Cluver","year":"2014","journal-title":"Aids"},{"issue":"8","key":"pone.0279289.ref033","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1080\/09540121.2015.1018861","article-title":"ISIBINDI, creating circles of care for orphans and vulnerable children in South Africa: Post-programme outcomes","volume":"27","author":"M Visser","year":"2015","journal-title":"AIDS care"},{"issue":"12","key":"pone.0279289.ref034","doi-asserted-by":"crossref","first-page":"e0208167","DOI":"10.1371\/journal.pone.0208167","article-title":"The DREAMS core package of interventions: A comprehensive approach to preventing HIV among adolescent girls and young women","volume":"13","author":"J Saul","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"pone.0279289.ref035","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1097\/QAD.0000000000003259","article-title":"Modeling DREAMS impact: trends in new HIV diagnoses among women attending antenatal care clinics in DREAMS countries","volume":"36","author":"J Saul","year":"2022","journal-title":"AIDS"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T13:24:59Z","timestamp":1671629099000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0279289"}},"subtitle":[],"editor":[{"given":"Hamid","family":"Sharifi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":35,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0279289","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]}}}