{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:06:29Z","timestamp":1790996789496,"version":"4.1.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007816","name":"Alcon","doi-asserted-by":"publisher","award":["66721403"],"award-info":[{"award-number":["66721403"]}],"id":[{"id":"10.13039\/100007816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To compare visual acuity and refractive results between topography-guided laser in situ keratomileusis (LASIK) planned with the Phorcides Analytic Engine (PAE) to results after wavefront-optimized (WFO) LASIK in subjects with preoperative oblique astigmatism in their manifest refraction.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This was a retrospective chart review of clinical results from eyes treated with topography-guided LASIK planned with PAE compared to eyes treated with WFO LASIK using the same Wavelight<jats:sup>\u00ae<\/jats:sup> excimer laser system. All included subjects had preoperative oblique astigmatism. Residual refractive error and visual acuity (uncorrected and corrected) were the measures of interest, at the visit closest to 90 days postoperative.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A matched data set from 100 WFO and 97 PAE eyes was extracted from clinical records. At the postoperative visit the PAE group showed lower residual refractive cylinder (p = 0.04), uncorrected distance visual acuity (UDVA) (-0.06 PAE vs. -0.02 WFO, p &lt; 0.01) and distance corrected visual acuity (CDVA) (p &lt; 0.01). The percentage of eyes with a mean refraction spherical equivalent (MRSE) magnitude within 0.25 D and 0.50 D of plano was statistically significantly higher in the PAE group (p = 0.04 and 0.01, respectively). A statistically significantly higher percentage of eyes in the PAE group had UDVA better than or equal to -0.10 logMAR (20\/16 Snellen, 36% vs 22%, p = 0.04). More eyes gained CDVA after surgery in the PAE group (53% vs 32%, p &lt; 0.01). There were five enhancements in the WFO group versus none in the PAE group, a statistically significant difference (p = 0.03).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Visual acuity and refractive outcomes after LASIK using PAE in eyes with oblique astigmatism in their preoperative refraction were statistically significantly better than those obtained when WFO treatment was used. The number of refractive outliers and the number of retreatments were also significantly lower with PAE treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279357","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T18:28:15Z","timestamp":1671474495000},"page":"e0279357","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of refractive and visual acuity results after Contoura\u00ae Vision topography-guided LASIK planned with the Phorcides Analytic Engine to results after wavefront-optimized LASIK in eyes with oblique astigmatism"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-9620","authenticated-orcid":true,"given":"Phillip","family":"Brunson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Michael","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0964-5035","authenticated-orcid":true,"given":"Richard","family":"Potvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"issue":"8","key":"pone.0279357.ref001","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jcrs.2016.07.012","article-title":"Modern laser in situ keratomileusis outcomes.","volume":"42","author":"HP Sandoval","year":"2016","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"pone.0279357.ref002","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00055735-200208000-00012","article-title":"Astigmatism and LASIK","volume":"13","author":"HK Wu","year":"2002","journal-title":"Curr Opin Ophthalmol"},{"key":"pone.0279357.ref003","article-title":"Femtosecond LASIK for the correction of low and high myopic astigmatism.","author":"R Ca\u00f1ones-Zafra","year":"2021","journal-title":"Int Ophthalmol"},{"key":"pone.0279357.ref004","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.jcrs.2010.05.014","article-title":"Efficacy of laser in situ keratomileusis in correcting anterior and non-anterior corneal astigmatism: comparative study.","volume":"36","author":"L Kugler","year":"2010","journal-title":"J Cataract Refract Surg"},{"key":"pone.0279357.ref005","doi-asserted-by":"crossref","first-page":"779","DOI":"10.5301\/ejo.5000294","article-title":"Astigmatism prevalence and biometric analysis in normal population.","volume":"23","author":"G Nemeth","year":"2013","journal-title":"Eur J Ophthalmol"},{"key":"pone.0279357.ref006","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jcrs.2010.02.025","article-title":"Analysis of biometry and prevalence data for corneal astigmatism in 23,239 eyes.","volume":"36","author":"PC Hoffmann","year":"2010","journal-title":"J Cataract Refract Surg"},{"key":"pone.0279357.ref007","article-title":"On a peculiar defect in the eye, and a mode of correcting it.","author":"GB Airy","year":"1827","journal-title":"William Blackwood;"},{"key":"pone.0279357.ref008","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jcrs.2012.03.032","article-title":"Effect of axis orientation on visual performance in astigmatic eyes.","volume":"38","author":"H Kobashi","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"pone.0279357.ref009","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1475-1313.2000.tb01122.x","article-title":"Measuring contrast sensitivity with inappropriate optical correction.","volume":"20","author":"RL Woods","year":"2000","journal-title":"Ophthalmic and Physiological Optics"},{"key":"pone.0279357.ref010","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1038\/s41598-021-95358-z","article-title":"Comparison of corneal irregular astigmatism by the type of corneal regular astigmatism.","volume":"11","author":"Y Ueno","year":"2021","journal-title":"Sci Rep"},{"issue":"8","key":"pone.0279357.ref011","doi-asserted-by":"crossref","first-page":"E549","DOI":"10.1097\/OPX.0b013e3181e61b8f","article-title":"Subjective blur limits for cylinder.","volume":"87","author":"H Guo","year":"2010","journal-title":"Optom Vis Sci"},{"key":"pone.0279357.ref012","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12886-021-01959-7","article-title":"Prediction of postoperative refractive astigmatism before toric intraocular lens implantation","volume":"21","author":"A. 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