{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:55:56Z","timestamp":1794048956832,"version":"4.8.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774112"],"award-info":[{"award-number":["81774112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"a grant from Siming Scholars from Shuguang Hospital","award":["SGXZ-201913"],"award-info":[{"award-number":["SGXZ-201913"]}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC2020CR2007A"],"award-info":[{"award-number":["SHDC2020CR2007A"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nIntroduction<\/jats:title>\nAnal fistula is the natural evolution of perianal abscess and one of the most common perianal diseases for adults. For complex fistula, it is still very challenging for anorectal surgeons to manage. With the introduction of laser technique in surgery, it is becoming more and more widely used for the treatment of cryptoglandular anal fistula. During the past decade, numerous studies have reported the clinical effectiveness and postoperative outcomes of different forms of laser treatment for anal fistula. However, as these studies were varied in terms of baseline characteristics, the evidence for the true clinical effectiveness of laser treatment for anal fistula need further critical appraisal. Therefore, the purpose of this study is to evaluate the outcomes of surgical laser therapy for cryptoglandular anal fistula stratified by laser type and Parks\u2019 classification through a synthesis of quantitative and qualitative evidence.<\/jats:p>\n<\/jats:sec>\n\nMethods and analysis<\/jats:title>\nThis study will be carried out with adherence to the Cochrane Handbook. We will search PubMed, Cochrane Library, and Embase until June, 2022 to identify all relevant interventional and observational studies examining the effects of laser therapy on the clinical outcomes for cryptoglandular anal fistula. Data extraction from eligible studies will be performed independently by two unblinded authors using standardized extraction forms. Risk of bias assessment for each study will be conducted using Cochrane tool for randomized controlled trials (RCTs) and the Newcastle\u2013Ottawa scale (NOS) tool for observational studies. The DerSimonian-Laird random-effects model will be used to calculate the pooled estimates. Heterogeneity will be examined by subgroup analysis stratified by laser type and Parks\u2019 classification and other study characteristics. Potential publication bias will be assessed by funnel plot symmetrical and Egger\u2019s regression tests.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nThe synthesis of quantitative and qualitative evidence of this systemic review will yield updated and comprehensive evidence of laser treatment on specific outcomes, which can provide anorectal surgeons with high level evidence-based recommendations to improve patient care and clinical outcomes. OSF registration number:<\/jats:bold> DOI 10.17605\/OSF.IO\/36ADW<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0279388","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T18:24:52Z","timestamp":1672856692000},"page":"e0279388","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Surgical laser therapy for cryptoglandular anal fistula: Protocol of a systematic review and meta-analysis"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-957X","authenticated-orcid":true,"given":"Zubing","family":"Mei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"pone.0279388.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcol.2019.09.009","article-title":"Epidemiological profile of patients with fistula in ano","volume":"40","author":"FR Fugita","year":"2020","journal-title":"Journal of Coloproctology (Rio de Janeiro)"},{"issue":"2","key":"pone.0279388.ref002","doi-asserted-by":"crossref","first-page":"0300060520986669","DOI":"10.1177\/0300060520986669","article-title":"Current concepts in the pathogenesis of cryptoglandular perianal fistula","volume":"49","author":"M W\u0142odarczyk","year":"2021","journal-title":"Journal of International Medical Research"},{"key":"pone.0279388.ref003","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2147\/CEG.S198796","article-title":"Management of Complex Cryptoglandular Anal Fistula: Challenges and Solutions.","volume":"13","author":"P Garg","year":"2020","journal-title":"Clinical and experimental gastroenterology"},{"key":"pone.0279388.ref004","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijsu.2017.02.095","article-title":"Transanal opening of intersphincteric space (TROPIS)\u2014A new procedure to treat high complex anal fistula.","volume":"40","author":"P. 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